fa بررسی اثرات محافظتی رزوراترول در کاهش فاکتورهای التهابی بعد از جراحی پیوند بای‌پس عروق کرونر دستگاه قلب و عروق Cardiovascular System پژوهشي Original <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#1f4e79">زمینه:</span></span></span></span></b> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:.1pt">رزوراترول دارای خواص آنتی‌اکسیدانی و ضد التهابی بوده و اثرات محافظتی چشمگیری بر قلب دارد. با وجود اثرات درمانی متعدد رزوراترول در طب سنتی، در رابطه با اثرات ضدالتهابی آن، تفاوت‌هایی در یافته‌های مطالعات مختلف مشاهده می‌شود. لذا هدف این مطالعه بررسی اثرات محافظتی رزوراترول در کاهش فاکتورهای التهابی در بیماران بعد از جراحی پیوند بای پس عروق کرونر می‌باشد.</span></span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#1f4e79">مواد و روش‌ها:</span></span></span></span></b> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">پژوهش حاضر به‌صورت مورد- شاهدی بر روی </span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">۶۰</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"> بیمار مراجعه</span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">‌</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">کننده به مرکز قلب بوشهر که </span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">تحت عمل جراحی بای‌پس عروق کرونر (</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">CABG</span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">) قرار گرفته بودند،</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"> انجام شد. </span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">بیماران به دو گروه کنترل و مداخله تقسیم شدند.</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"> گروه کنترل بیمارانی </span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">بودند</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"> که تحت عمل جراحی </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">CABG</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"> قرار گرفتند و بدون مصرف رزوراترول بودند </span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">در صورتیکه</span></span></span></span> <span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">گروه مداخله بیمارانی بودند که پس از جراحی، روزانه دو بار رزوراترول را به‌صورت کپسول‌های ۲۵۰ میلی‌گرمی دریافت نمودند</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">. </span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">مصرف رزوراترول در گروه مداخله از روز دهم پس از جراحی به‌مدت ۶۰ روز ادامه یافت. در ابتدا و پایان مطالعه از تمامی بیماران در هر دو گروه، ۱۰ سی‌سی خون گرفته شد و برای بررسی سطح خونی فاکتورهای التهابی مورد ارزیابی قرار گرفت</span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">.&nbsp; </span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#1f4e79">یافته‌ها:</span></span></span></span></b> <span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">نتایج نشان داد که </span></span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">تغییرات سطح سرمی پروتئین واکنشگر </span></span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">C</span></span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">، اینترلوکین&ndash; ۶ و سرعت رسوب گلبول‌های قرمز خون </span></span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">در گروه مداخله نسبت به گروه کنترل بیشتر بود. بر همین اساس میانگین </span></span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">این فاکتورهای التهابی </span></span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">در گروه مداخله نسبت به گروه کنترل کاهش بیشتری نشان داد. تغییرات </span></span></span></span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">تعداد گلبول‌های سفید خون </span></span></span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt">در گروه مداخله نسبت به گروه کنترل اگرچه بیشتر بود اما این تفاوت معنی‌دار نمی‌باشد.</span></span></span></span></span> <b><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"><span style="letter-spacing:-.1pt"></span></span></span></span></span></b></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#1f4e79">نتیجه‌گیری:</span></span></span></span></b> <span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d">رزوراترول به‌عنوان یک آنتی‌اکسیدان قوی موجب بهبود عملکرد قلب و کاهش فاکتورهای التهابی در بیماران مورد مطالعه گردید. </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#0d0d0d"></span></span></span></span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#002060"><span style="letter-spacing:-.1pt">Background:</span></span></span></span></span></b> <span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#404040"><span style="letter-spacing:-.1pt">With its antioxidant and anti-inflammatory properties, resveratrol has significant protective effects on the heart. Despite the numerous therapeutic effects of resveratrol in traditional medicine, its anti-inflammatory effects are not conclusively approved. Therefore, the aim of this study is to investigate the protective effects of resveratrol in reducing inflammatory factors in patients after coronary artery bypass graft surgery.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#002060">Materials and Methods:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#404040">The present study was conducted as a case-control study on 60 patients presenting to Bushehr Heart Center who underwent coronary artery bypass grafting. Patients were divided into a control and intervention group. The control group consisted of patients who underwent CABG surgery without receiving resveratrol, whereas the intervention group included patients who received resveratrol capsules at a dose of 250 mg twice daily, following the surgery. Resveratrol administration in the intervention group continued for 60 days from the tenth day post-surgery. At the beginning and end of the study, 10 mL of blood was collected from all patients in both groups to assess the blood levels of inflammatory factors.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#002060">Results:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#404040"><span style="letter-spacing:-.1pt">The results showed that the changes in serum levels of C-reactive protein, interleukin-6 and erythrocyte sedimentation rate were greater in the intervention group compared to the control group. Accordingly, the mean levels of these inflammatory factors decreased more in the&nbsp;</span></span></span></span></span></span></span></span><span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#404040"><span style="letter-spacing:-.1pt">intervention group than in the control group. Although the changes in white blood cell count were greater in the intervention group compared to the control group, this difference was not statistically significant.</span></span></span></span></span><span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#404040"></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#002060">Conclusion:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#404040"><span style="letter-spacing:.1pt">Resveratrol as a strong antioxidant improved heart function and decreased inflammatory factors in the studied patients.</span></span></span></span></span><span lang="EN" style="font-size:9.0pt"><span style="line-height:115%"><span iransans="" style="font-family:"><span style="color:#404040"><span style="letter-spacing:.1pt"></span></span></span></span></span></span></span></span></div> آنتی‌اکسیدان, بیماری قلبی- عروقی, رزوراترول, فاکتورهای التهابی Antioxidant, Cardiovascular disease, Resveratrol, Inflammatory factors 744 757 http://ismj.bpums.ac.ir/browse.php?a_code=A-10-1115-67&slc_lang=fa&sid=1 Rahimeh Rahimi رحیمه رحیمی 5700319475328460018989 5700319475328460018989 No Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IRAN گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی بوشهر، بوشهر، ایران Mehdi Sadeghi مهدی صادقی m.sadeghi@bpums.ac.ir 5700319475328460018990 5700319475328460018990 Yes Department of Physiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IRAN گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی بوشهر، بوشهر، ایران Ali Movahed علی موحد 5700319475328460018991 5700319475328460018991 No Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IRAN گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی بوشهر، بوشهر، ایران