ISMJ

Background: In the human body, there are some special systems to interact with pathogens of free radicals that are called antioxidant immune system in some human diseases. Diabetes is one of the most important common chronic diseases with changing in antioxidant capacity. Therefore, this research was done with the purpose of determination and comparison of antioxidant capacity of diabetic patients, saliva with control Grope. Material and Methods: This study was a case control study. 50 people with type II diabetes referring to Zahedan diabetic center assigned as case group, they were compared with 50 participants from control group. Both groups had similar age, sex and all other criteria. Total antioxidant capacity of saliva evaluated with FRAP (Ferric reducing ability of plasma) method. The data was analyzed by T-test and ANOVA. Results: Mean and standard deviation (Mean ± SD) of antioxidant capacity of saliva in case group was 0.442±0.251 µmol/liter and in control group was 0.667±0.421 µmol/liter. Reduction of antioxidant capacity of saliva of case group was statistically significant using T-test and ANOVA analysis (p=0.002). Conclusion: In this study reduction of antioxidant capacity of diabetic patients, saliva was significantly lower than control group. Therefore, it is recommended that these people use more natural antioxidants.