Volume 22, Issue 1 (Iranian South Medical Journal 2019)                   Iran South Med J 2019, 22(1): 29-40 | Back to browse issues page


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Najafiasl M, Osfouri S, Azin R, Zaeri S. The Effect of Adding Alginate Natural Polymer on the Structure of Polyvinyl Alcohol Biocompatible Nanofibers in Electrospinning Process. Iran South Med J 2019; 22 (1) :29-40
URL: http://ismj.bpums.ac.ir/article-1-1046-en.html
1- Department of Chemical Engineering, School of Petroleum, Gas, and Petrochemical Engineering, Persian Gulf University, Bushehr, Iran
2- Department of Chemical Engineering, School of Petroleum, Gas, and Petrochemical Engineering, Persian Gulf University, Bushehr, Iran , osfouri@pgu.ac.ir
3- Department of Petroleum Engineering, School of Petroleum, Gas, and Petrochemical Engineering, Persian Gulf University, Bushehr, Iran
4- Department of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract:   (4665 Views)
Background: Nowadays, in order to preserve the environment and sustainable development, the use of natural and renewable resources is a priority for industries. High performance and specific structure of nano-biocompatible materials has attracted researchers. In this research, alginate polymer, which is
generally obtained from marine sources such as algae, was added to polyvinyl alcohol nanofibers in order to improve their biocompatibility and investigate the effect of solution parameters on their morphology.
Materials and Methods: Polyvinyl alcohol nanofibers were produced in different concentrations by electrospinning to investigate the effect of concentration, adding alginate polymer and Triton x-100 surfactant. The quality of nanofibers and rheology behavior of polymer solutions were evaluated using scanning electron microscopy, rheometry and tensiometer.
Results: The results showed that increasing the concentration of polymer solution increased the diameter of nanofibers, as well as the viscosity of the polymer solution, such that a polyvinyl alcohol solution with 10wt.% concentration produced more uniform nanofibers. At first, adding alginate to the polyvinyl alcohol solution deteriorated electrospinning, however, production of nanofibers was improved by increasing polyvinyl alcohol solution to 10wt.%. Also, the results showed that adding Triton x-100 surfactant to the polymer solution affected the dominant mechanism in electrospinning by reducing surface tension and viscosity of the solution at polyvinyl alcohol solution 6wt.% and 10wt.%, respectively.
Conclusion: Under optimized conditions of solution parameters, suitable nanofibers will be produced, which will be applicable in many industries, such as drug delivery.
Full-Text [PDF 867 kb]   (2122 Downloads)    
Type of Study: Original | Subject: Biochemistry. Cell Biology and Genetics
Received: 2018/09/8 | Accepted: 2018/10/31 | Published: 2019/04/7

References
1. Li Z, Wang C. One-Dimensional nanostructures: electrospinning technique and unique nanofibers. New York: Springer Science & Business Media, 2013, 1. [DOI:10.1007/978-3-642-36427-3]
2. Mitra A.K, Cholkar K, Mandal A. Electrospun nanofibers in drug delivery, emerging nanotechnologies for diagnostics, drug delivery, and medical devices. New York: William Andrew, 2017, 190.
3. Nayak R, Padhye R, Kyratzis L, et al. Recent advances in nanofibre fabrication techniques. Text Res J 2011; 82(2): 129-47. [DOI:10.1177/0040517511424524]
4. Dharani S, Mulmudi H, Yantara N, et al. High efficiency electrospun TiO2 nanofiber based hybrid organic-inorganic perovskite solar cell. Nanoscale 2014; 6(3): 1675-9. [DOI:10.1039/C3NR04857H]
5. Fang X, Ma H, Shen M, et al. Facile mmobilization of gold nanoparticles into electrospun polyethyleneimine/polyvinyl alcohol nanofibers for catalytic applications. J Mater Chem 2011; 21(12): 4493-501. [DOI:10.1039/c0jm03987j]
6. Langenhove L. Advances in smart medical textiles: treatments and health monitoring. Netherlands: Elsevier Science, 2015, 59-62
7. Thakkar S, Misra M. Electrospun polymeric nanofibers: New horizons in drug delivery. Eur J Pharm Sci 2017; 107: 148-67. [DOI:10.1016/j.ejps.2017.07.001]
8. Hu W, Wu Y, Hu Z. The development of an alginate/polycaprolactone composite scaffold for in situ transfection application. Carbohydr Polym 2018, 183: 29-36. [DOI:10.1016/j.carbpol.2017.11.030]
9. Ahmadi R, Osfouri Sh, Azin R. Synthesis and Characterization of Nanoparticles from Cuttl bone (sepia pharaonis) of Persian Gulf. Iran South Med J 2018; 21(4): 287-96. (Persian)
10. Liu X, Nielsen LH, Kłodzińska SN, et al. Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing. Eur J Pharm Biopharm 2018; 123: 42-9. [DOI:10.1016/j.ejpb.2017.11.004]
11. Biro K, Thacl D, Ochsendorf F, et al. Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis 2003; 49(2): 80-4 [DOI:10.1111/j.0105-1873.2003.00184.x]
12. Tort S, Acartürk F. Preparation and characterization of electrospun nanofibers containing glutamine. Carbohydr Polym 2016; 152: 802-14. [DOI:10.1016/j.carbpol.2016.07.028]
13. Huang Z, Zhang Y, Kotaki M, et al. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos Sci Technol 2003; 63(15): 2223-53. [DOI:10.1016/S0266-3538(03)00178-7]
14. Babitha S, Rachita L, Karthikeyan K, et al. Electrospun protein nanofibers in healthcare: A review. Int J Pharm 2017; 523(1): 52-90. [DOI:10.1016/j.ijpharm.2017.03.013]
15. Badrossamay M, Balachandran K, Capulli A, et al. Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning. Biomaterials 2014; 35(10): 3188-97. [DOI:10.1016/j.biomaterials.2013.12.072]
16. Jalaja K, James N. Electrospun gelatin nanofibers: A facile cross-linking approach usingoxidized sucrose. Int J Biol Macromol 2015; 73: 270-8. [DOI:10.1016/j.ijbiomac.2014.11.018]
17. Ma G, Fang D, Liu Y, et al. Electrospun sodium alginate/poly (ethylene oxide) core-shell nanofibers scaffolds potential for tissue engineering applications. Carbohydr Polym 2012; 87(1): 737-43. [DOI:10.1016/j.carbpol.2011.08.055]
18. Liakos I, Rizzello L, Scurr D, et al. All-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties. Int J Pharm 2014; 463(2): 137-45. [DOI:10.1016/j.ijpharm.2013.10.046]
19. Aydogdu A, Sumnu G, Sahina S. A novel electrospun hydroxypropyl methylcellulose/ polyethylene oxide blend nanofibers: morphology and physicochemical properties. Carbohydr Polym 2018; 181: 234-46. [DOI:10.1016/j.carbpol.2017.10.071]
20. Kiyak YE, Cakmak E. Nanofiber Production Methods. Electron J Text Technol 2014; 8(3): 49-60.
21. Mendes A, Strohmenger T, Goycoolea F, et al. Electrostatic self-assembly of polysaccharides into nanofiber. Colloids Surf A Physicochem Eng Asp 2017; 531: 182-8. [DOI:10.1016/j.colsurfa.2017.07.044]
22. Xing X, Wang Y, Li B. Nanofibers drawing and nanodevices assembly in poly(trimethylene terephthalate). Opt Express 2008; 16(14): 10815-22. [DOI:10.1364/OE.16.010815]
23. Deng Y, Kuiper J. Functional 3D tissue engineering scaffolds: materials, technologies, and applications. United Kingdom: Woodhead Publishing, an imprint of Elsevier, 2018, 204.
24. Bhardwaj N, Kundu S. Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv 2010; 28(3): 325-47. [DOI:10.1016/j.biotechadv.2010.01.004]
25. Bhattarai N, Li Z, Edmondson D, et al. Alginate-based nanofibrous scaffolds: structural, mechanical, and biological properties. Adv Mater 2006; 18(11): 1463-7. [DOI:10.1002/adma.200502537]
26. Fatemi MJ, Pegahmehr M, Khajerahimi AA et al. Evaluation of Polyethylen- Vazeline guaze and melolin on healing of graft donor sites in rat. Iran South Med J 2014; 17(3): 298-306. (Persian)
27. Islam M, Karim M. Fabrication and characterization of poly (vinyl alcohol)/alginate blend nanofibers by electrospinning method. Colloids Surf A Physicochem Eng Asp 2010; 366(1-3): 135-140. [DOI:10.1016/j.colsurfa.2010.05.038]
28. Stone S, Gosavi P, Athauda T, et al. In situ citric acid crosslinking of alginate/polyvinyl alcohol electrospun nanofibers. Mater Lett 2013; 112: 32-35. [DOI:10.1016/j.matlet.2013.08.100]
29. Lee K, Mooney D. Alginate: properties and biomedical applications. Prog Polym Sci 2012; 37(1): 106-26. [DOI:10.1016/j.progpolymsci.2011.06.003]
30. Jain D, Bar-Shalom D. Alginate drug delivery systems: application in context of pharmaceutical and biomedical research. Drug Dev Ind Pharm 2013; 40(12): 1576-84. [DOI:10.3109/03639045.2014.917657]
31. Bonino C, Krebs M, Saquing C, et al. Electrospinning alginate-based nanofibers: From blends to crosslinked low molecular weight alginate-only systems. Carbohydr Polym 2011; 85(1): 111-9. [DOI:10.1016/j.carbpol.2011.02.002]
32. Varshosaz J, Jajanian-Najafabadi A, Soleymani A, et al. Poly (butylene adipateco-terephthalate) electrospun nanofibers loaded with 5-fluorouracil and curcumin in treatment of colorectal cancer cells. Polym Test 2018; 65: 217-30. [DOI:10.1016/j.polymertesting.2017.11.020]
33. Bonino C, Efimenko K, Jeong S, et al. Three-dimensional electrospun alginate nanofiber mats via tailored charge repulsions. small 2012; 8(12): 1928-36. [DOI:10.1002/smll.201101791]
34. Fan L, Du Y, Wang X, et al. Preparation and characterization of alginate/poly (vinyl alcohol) blend fibers. Macromol Sci Part A 2005; 42(1): 41-50. [DOI:10.1081/MA-200040956]
35. Zhang C, Yuan X, Wu L, et al. Study on morphology of electrospun poly (vinyl alcohol) mats. Eur Polym J 2005; 41(3): 423-32. [DOI:10.1016/j.eurpolymj.2004.10.027]
36. Caykara T, Demirci S. Preparation and characterization of blend films of poly (vinyl alcohol) and sodium alginate. Macromol Sci 2006; 43(7): 1113-21. [DOI:10.1080/10601320600740389]
37. Tarun K, Gobi N. Calcium alginate/PVA blended nano fiber matrix for wound dressing. Indian J Fibre Text Res 2012; 37: 127-32.
38. Zheng JY, Zhuang MF, Yu ZJ, et al. The effect of surfactants on the diameter and morphology of electrospun ultrafine nanofiber. J Nanomater 2014; 1-9 [DOI:10.1155/2014/689298]
39. Jia L, Qin X. The effect of different surfactants on the electrospinning poly (vinyl alcohol) (PVA) nanofibers. J Therm Anal Calorim 2013; 112(2): 595-605. [DOI:10.1007/s10973-012-2607-9]
40. Dogac Y, Deveci I, Mercimek B, et al. A comparative study for lipase immobilization onto alginate based composite electrospun nanofibers with effective and enhanced stability. Int J Biol Macromol 2017; 96: 302-11. [DOI:10.1016/j.ijbiomac.2016.11.120]

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