:: Volume 6, Issue 1 (Iranian south medical of journals 2003) ::
Iran South Med J 2003, 6(1): 25-30 Back to browse issues page
Treatment of candida vaginitis: comparison of single and sequential dose of fluconazole
Farahnaz Kamali Mrs, Tayebeh Gharibi Mrs , Behrooz Naiemi Mr, Poorandokht Afshary Ms
Abstract:   (20204 Views)
Fluconazole is one of the triazole antifungal agent for Candida albican. For comparison of single versus sequential dose of fluconazole, a double-blind randomized clinical trial was counducted on 80 married 20-45 years old women who had chronic vaginal candidiasis. The patients randomized into two groups, 40 patients received two ( zero and 72 hours ) doses of fluconazole and the other group received one 150 mg dose of the drug at zero and placebo at 72 hours later. The patients were examined at 2 & 6 weeks after treatment. The groups showed decreased signs and symptoms of vaginal candidiasis during examination periods, however there was no significant difference between groups (p>0.05). Wet mount & culture were negative in the 2nd week in two groups but at the 6th week after treatment, 95.3% and 72.5% of patients in control and case groups, respectively had negative results (p<0.05). Therefore, single and sequential doses of fluconazole have the same result for treatment of vaginal candidiasis but sequential dose reduces the relapse rate of the disease.
Keywords: fluconazole, vaginitis, candidiasis, fungal
Full-Text [PDF 145 kb]   (1313 Downloads)    
Type of Study: Original | Subject: General
Received: 2009/01/19 | Accepted: 2009/01/19 | Published: 2009/01/19


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Volume 6, Issue 1 (Iranian south medical of journals 2003) Back to browse issues page