:: Volume 22, Issue 6 (Iranian South Medical Journal 2020) ::
Iran South Med J 2020, 22(6): 371-380 Back to browse issues page
Correlation of Preoperative HE-4 and CA125 with Ovarian Cancer Staging in Ahvaz Imam Khomeni Hospital
Fatemeh Cheraghi1, Mahvash Zargar1, AmirReza Bolkheir 2
1- Department of Obstetrics and Gynecology, School of Medicine, Jondishapoor University of medical science, Ahvaz, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Jondishapoor University of medical science, Ahvaz, Iran , bolkhayramirreza@yahoo.com
Abstract:   (1586 Views)
Background: Given that ovarian cancer symptoms are nonspecific and that appropriate surgical staging and pathological grading are important for the best treatment and prognosis of patients, this study aimed to determine the correlation of preoperative serum levels of CA125 and He4 with staging and grading.
Materials and Methods: This cross-sectional study recruited 29 patients with epithelial ovarian cancer who underwent staging based on FIGO protocol and grading by pathologist during 2011-13. Serum CA125 and He4 were determined preoperatively to measure the correlation of these tumor markers with staging and grading.
Results: We did not observe a significant correlation between preoperative serum levels of CA125 and He4, and ovarian epithelial cancer staging and grading (P>0.05). However, serum levels of CA125 and He4 were significantly correlated with each other (P>0.001).
Conclusion: Based on this study, we cannot differentiate epithelial ovarian cancer surgical staging or pathological grading by preoperative CA125 and He4 serum levels.  
Keywords: Ovarian epithelial cancer, Surgical staging, He4, CA125.
Full-Text [PDF 592 kb]   (423 Downloads)    
Type of Study: Original | Subject: Gynecology
Received: 2019/09/23 | Accepted: 2019/12/1 | Published: 2020/01/28
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