:: Volume 13, Issue 1 (Iranian South Medical of Journal 2010) ::
Iran South Med J 2010, 13(1): 24-30 Back to browse issues page
The assessment of growth inhibition effect of Copper chloride and 8-Hydroxyquinoline compound on Trichophyton verrucosum
Behrouz Naiemi Mr 1, Sasan Rezaie Mr, Farideh Zeini Mrs
1- , b.naeimi1350@gmail.com
Abstract:   (19063 Views)
Background: Dermatophytosis or ring worm is one of the most common fungal infections. Trichophyton verrucosum (T.verrucosum) is common among the agents that cause dermatophytosis. The aim of the present study was to evaluate of antifungal activity of copper chloride (cucl2) and 8- hydroxyquinolin compound on T.verrucosum. Methods: One standard strain and two clinical isolated of T.verrucosum were used in this study. The standardized method, M-38 A for filamentous fungi, was used according to the guidelines of National Committee for Clinical and Laboratory Standards (NCCLS) to determine MIC. The effect of CuCl2 and 8-Hydroxyquinolin investigated by using various concentrations of this compound in T.verrucosum cultures. Results: Cucl2 and 8-Hydroxyquinolin compound exhibited antifungal activity on the three mentioned strains and the MIC of this compound was 25μg/ml. Conclusion: Cutaneous The new antifungal drug scheming is required to discover new antifungal agent. The data showed that Cucl2 and 8-Hydroxyquinolin compound had antifungal effect, so they could be a good candidate for making of new antifungal compounds.
Keywords: dermatophyte, Trichophyton verrucosum, antifungal, CuCl2, 8-Hydroxyquinolin
Full-Text [PDF 700 kb]   (2066 Downloads)    
Type of Study: Original | Subject: General
Received: 2009/01/21 | Accepted: 2009/05/31 | Published: 2010/02/17

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Volume 13, Issue 1 (Iranian South Medical of Journal 2010) Back to browse issues page