:: Volume 15, Issue 3 (Iranian South Medical Journal 2012) ::
Iran South Med J 2012, 15(3): 193-200 Back to browse issues page
Comparison of the effect of clomiphene citrate and the letrozole for ovulation induction in infertile women with polycystic ovarian syndrome
Elham Rahmani 1, Shahnaz Ahmadi2, Niloofar Motamed3, Hesamoldin Maneshi4, Soghra Ghasemi2
1- School of Medicine, Bushehr University of medical science, Bushehr, IRAN , بوشهر، دانشکده پزشکي، دانشگاه علوم پزشکي بوشهر
2- School of Medicine, Bushehr University of medical science, Bushehr, IRAN
3- The Persian Gulf for Nuclear Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, IRAN
4- Bushehr University of medical science, Bushehr, IRAN
Abstract:   (104380 Views)

Background: Anovulation is one of the most common causes of infertility. Different drugs in variousroutes are prescribed for its treatment. Clomiphene citrate (Clomiphene) and Letrozole are categorized as ovulation induction drugs. In the present study, the effect of Clomiphene and Letrozole, using step up method, is compared with each other in the treatment of infertility. Materials and Methods: In a randomized controlled clinical trial, 200 infertile patients with anovulation referred to infertility clinic of Bushehr University of Medical Sciences during 2008-2010 were studied in two equal groups. Informed written consent was obtained from all patients. For patients in each group, Letrozole or Clomiphene was prescribed from the third day of menstruation for five days in an increasing protocol of one, two and three tablets. Ovulation and endometrial thickness were evaluated by ultrasonography in 13th-14th days and pregnancy was confirmed by ßHCG. Results: There were nosignificant differences regarding baseline demographic and fertility variables between two groups (p value> 0.05). Follicle formation (P value = 0.9), pregnancy rate (clomiphene 14.54% and letrozole 12.26%, P value=0.19), abortion rate and drug side effects were similar between two groups (p value> 0.05). In letrozole group, endometrial thickness was significantly lesser than clomiphene group. Estradiol level per follicle was higher in letrozole group (108.3+17.44) in comparison with clomiphene group (172.4+20.33) (P value< 0.0001). Conclusion: It seems that clomiphene and letrozole effectiveness in treating infertility due to anovulation are the same. Moreover, they are similar in ovulation induction and pregnancy rate. Considering patient compliance, cost and drug side effects one.

Keywords: clomiphene, letrozole, polycystic ovarian syndrome, infertility
Full-Text [PDF 269 kb]   (7926 Downloads)    
Type of Study: Original | Subject: General
Received: 2012/06/17 | Accepted: 2012/06/17 | Published: 2012/06/17

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Volume 15, Issue 3 (Iranian South Medical Journal 2012) Back to browse issues page