:: Volume 17, Issue 4 (Iranian South Medical Journal 2014) ::
Iran South Med J 2014, 17(4): 593-601 Back to browse issues page
Association of Helicobacter pylori infection with lipid profiles: The Persian Gulf Healthy Heart Study
Hussain Darabi1, Fahimeh Hadavand1, Afshin Ostovar1, Iraj Nabipour2, Zahra Molaei Manesh1, Farzaneh Yousefi1, Katayon Vahdat *3
1- The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, IRAN
2- The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, IRAN
3- The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, IRAN , vahdatpg@bpums.ac.ir
Abstract:   (5265 Views)

Background: Helicobacter pylori (H.pylori) infection may contribute to the development of extra-gastrointestinal manifestations like cardiovascular diseases. Detection of Helicobacter pylori in Athrosclerotic plaques is a strong evidence for this association which may play a role in pathogenesis of atherosclerosis with classic cardiovascular risk factor such as hypertension and lipid profile. The aim of this study was to explore the influence of H. pylori infection on lipid profiles in a large community- based study. Material and Methods: A total of 1754 (50.8% Female & 49.2% male) subjects (age >25 years old) were selected randomely from Monica Healthy Heart Study project. H. pylori status was determined by IgG ELISA method. Subjects with titers > 30 Iu/ml were cansidered seropositive. Data were analazed by using statistical software Spss version 18 and probability values <0.05 were considered statistically significant. Results: In multiple logistic regression analyses H.pylori infection did not show significant association with Lipid profiles (low HDL- cholesterol and High LDL- cholesterol) after controlling for age, sex, body mass index, hypertension, type 2 diabetes mellitus, smoking and circulating hsCRP levels.(P>0.05) Conclusion: According to this large – scale population- based study in large northern cities of Persian Gulf, there was no significant association between H.pylori IgG seropositivity and lipid profiles in both men and women.

Keywords: Helicobacter pylori, High- density lipoprotein cholesterol, Atherosclerosis, Lipid profile.
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Type of Study: Original | Subject: General
Received: 2014/04/22 | Accepted: 2014/07/18 | Published: 2014/08/11


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Volume 17, Issue 4 (Iranian South Medical Journal 2014) Back to browse issues page