:: Volume 17, Issue 4 (Iranian South Medical Journal 2014) ::
Iran South Med J 2014, 17(4): 723-732 Back to browse issues page
Impacts of Persian Gulf blackfin stonefish crude venom on the haematological factors and serum enzymes levels of laboratory rat
Amir Vazirizadeh 1, Hussain Naderi-Manesh 2, Afshar Bargahi 3, Iraj Nabipour 3, Ghulam Hussain Mohebbi 3
1- Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, IRAN
2- Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, IRAN , naderman@modares.ac.ir
3- The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sceince, Bushehr, IRAN
Abstract:   (6404 Views)

Background: One of the venomous fishes of Persian Gulf is a type of stonefish called blackfin stonefish (Pseudosynanceia melanostigma) that is very poorly-known. This fish lives on the muddy bottoms of marine shallow waters and have venomous spines on its stone like body. The envenomation usually is happened by unwanted contact of human body to its body and the proteinic venom is injected into the skin. Upon the venom entrance to the body various symptoms and signs will occur that their intensity depends on the venom amount.The aim of study is the understanding of some pharmacological impacts of blackfin stonefish for future studies. Material and Methods: A total of 18 male laboratory rats were divided into three groups of control, second and third and envenomed by sub lethal doses (1/3 LD50 and ½ LD50) intravenously and the serum enzymes namely Creatine Phosphokinase, Lactate Dehydrogenase, Glutamate-Oxaloacetate Transaminase, Gamma-Glutamyl Transpeptidase , Alkaline Phosphatase and Amylase, serum electrolytes namely Sodium. Potassium and Calcium and also complete blood cells of control and experimental rats were measured. Results: The serum enzymes levels, potassium and calcium levels and withe blood cells count in envenomed rats by blackfin stonefish crude venom in compare with control rats had significant increase while the haemoglobin level, red blood cells count and also serum sodium level had significant decrease (p<0.001). Conclusion: The increase in hepatomascular enzyme levels, and the decrease in haemoglobin level can be a probable marker of the presence of rhabdomyolysis, haemolysis and also hepatotoxicity activities in the blackfin stonefish venom and that needs to the histopathologic studies in these systems.

Keywords: Blackfin stonefish, Venom, Persian Gulf, Rhabdomyolysis, Hepatotoxicity
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Type of Study: Original | Subject: General
Received: 2014/08/11 | Accepted: 2014/08/11 | Published: 2014/08/11

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Volume 17, Issue 4 (Iranian South Medical Journal 2014) Back to browse issues page