Background: Megatrends are long-lasting global developments in society, technology, economy and political conditions that their effects are not restricted to a particular geographic area. In future studies, megatrends in social, technology, environment, politics, and values (STEEP-V) should be considered. Material and Methods: The megatrends shaping healthcare in the new millennium were selected from the future studies. Trend analysis (macro to micro approach) was used to emerge key fields of action or areas of innovation in healthcare and related technologies that might be reflected in the health policies of I.R.Iran. Results: Ten megatrends shaping healthcare in the new millennium were identified. High capacities for innovation in emerging health technologies, policies for health insurance, paradigm shift from volume to value in healthcare delivery, and infrastructure for participatory medicine were found in the health policies of I.R.Iran. Conclusions: The majority of the health policies of I.R.Iran are in line of healthcare megatrends and these policies provide a great potential for healthcare reform. However, more emphasis should be paid on mobile health (m-Health), medical tourism, community-based medicine, systems medicine, personalized medicine, transformation of big data to knowledge and geriatric health in the health policies of I.R.Iran.