:: Volume 18, Issue 1 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(1): 64-70 Back to browse issues page
Comparison beta absorbed dose from 203Hg, 166Ho and 177LU isotopes in cortex and medulla in tree part kidney and integrated kidney using Monte Carlo method
Mohammad Mirzaei 1, Ali Asghar Mowlavi 2
1- Department of Physics, School of Shahid Chamran, Technical and Vocational University, Kerman, Iran , m.mirzaei@tvu.ac.ir
2- Department of Physics, School of Science, Hakim Sabzevari University, Sabzevar, Iran
Abstract:   (2687 Views)

Background: Large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. Therefore, radiation unwanted dose is created in kidney. As a result, exact calculation of prescribed medicine amount is important. In Mird pamphlet, 5 kidneys have considered in ellipsoidal shape that radiopharmaceutical is uniform distributed in them and gamma absorption fraction is calculated and recorded in the tables and the fraction of beta absorption is considered unit. While, kidney has internal organs and radioisotope is not uniform distributed in and beta absorbed fraction is not unit. Material and method: In this research, for the first time kidney is considered integrated shape and for the second time has been considered that it is consisted of three areas, pelvis, medulla and cortex. It is supposed that radiopharmaceutical is distributed in medulla. Then, beta absorbed dose is calculated in medulla and cortex using MCNPX code and is compared with integrated kidney results. Resuts: This research has been showed that beta absorbed dose from 203Hg, 166Ho and 177Lu isotopes in medulla is four times as much as dose in integrated kidney and beta dose in cortex is 0.004 to 0.012 times as much as beta dose in integrated kidney. Conclusion: Internal structure of kidney should be considered in simulation to achieve a more accurate prescribed dose. It is recommended that simulation results of three areas kidney are replaced with integrated kidney to prevent from renal toxicity.

Keywords: Absorbed dose, Medulla, Cortex, Monte Carlo method
Full-Text [PDF 421 kb]   (898 Downloads)    
Type of Study: Original | Subject: Urogenital System
Received: 2015/02/18 | Accepted: 2015/02/18 | Published: 2015/02/18

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Volume 18, Issue 1 (Iranian South Medical Journal 2015) Back to browse issues page