Background: Nanosilver is one of the most widely used nanomaterials in consumer products. However, little attention was paid to the dermal toxic of These particles on human health. This study aimed to examine the effect of nanosilver dermal absorption on renal function parameters. Materials and Methods: In this experimental study, 40 male BALB/c mice were randomly divided into 4 groups of 10 (nanosilver, positive control, sham control and negative control groups). After general anesthesia and shaving the back of all animals in near the vertebral column, the Bandage surface was treated in the nanosilver group, with a volume of 50 microliters of the nanosilver solution (100 µg/ml) ,and in the positive control group with the same amount of silver nitrate solution (100 µg/ml), and in the sham control group with the same amount of distilled water, then the Bandages were fixed in the skin surface, but the negative control group was without treatment and bandage. After 3 and 7 days, the bandages had opened, and the serum levels of Creatinine (Cr) and Blood Urea Nitrogen (BUN) were measured. Results: On 3 and 7 days, in nanosilver group, creatinine did not change significantly(p>0.05), but BUN levels showed significant increase compared to other groups (p<0.05). In addition, there wasn’t significant changes in the renal function parameters in 7-day compared to 3-day (p>0.05). Conclusion: In this study, a significant increase in BUN of nanosilver group can be indicate kidney dysfunction, therefore nanosilver dermal absorption can be have the toxic effects on the kidney function.