:: Volume 18, Issue 3 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(3): 664-679 Back to browse issues page
Sea cucumbers, the ocean of bioactive compounds
Hadi Ebrahimi1, Gholamhosean Mohebbi2, Amir Vazirizadeh3, Iraj Nabipour2, Mahmoud Nafisi Bahabadi 4
1- Department of Fisheries of Natural Resources Engineering–Fishery, the Persian Gulf University, Bushehr, Iran
2- Department of Marine Toxinology, The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr. Iran
3- Department of Marine Biotechnology, The Persian Gulf Research and Studies Center, The Persian Gulf University, Bushehr, Iran
4- Department of Fisheries of Natural Resources Engineering–Fishery, the Persian Gulf University, Bushehr, Iran , Nafisi2002@gmail.com
Abstract:   (7130 Views)

Sea cucumbers are one of the most echinoderms and from the class Holothuroidea. Some of their specific biological activities are including anti-cancer, anticoagulant, antihypertensive, anti-inflammatory, antimicrobial, antioxidant, anti-atherosclerosis and anti-tumor properties, as well as accelerate wound healing. The presence of different compounds such as saponins, chondroitin sulfates, glycosaminoglycans, sulfated Polysaccharides, glycoprotein, glycosphingolipids and essential and non essential fatty acids, are the causes of their biological properties. Saponins, which are produced for compatibility with the environment, are as theire secondary metabolites. These active compounds have biological properties like hemolytic, anti-tumor, anti-inflammatory, antibacterial, antiviral, ichthyotoxic, cytostatic, anti neogenic, antineoplastic, and uric acid lowering effects. Sea cucumber, have high economic value. In East Asia, Since ancient times, it have been traditionally used for the treatment of fatigue, sexual impotence, impotence caused by aging, constipation due to intestinal dryness, urinary incontinence, asthma, hypertension, arthritis and anemia. Also, toxins obtained from sea cucumber, have anti-viral, anti-tumor, anti-cancer and anti-pregnancy properties. According to literatures, the aqueous extract and high molecular weight compounds from sea cucumbers can inhibit tumor activity, via the apoptosis induction. Sea cucumbers because of the high percentage of protein and the absence of cholesterol, classified as an invigorating food. Because of different species of sea cucumbers in the Persian Gulf and Oman Sea the identification of compounds and biological properties of sea cucumber species in these regions is recommended to the researchers.

Keywords: sea cucumber, bioactive compounds, saponins, Persian Gulf
Full-Text [PDF 992 kb]   (3035 Downloads)    
Type of Study: Original | Subject: Disorders of Systemic, Metabolic or Environmental Origin
Received: 2015/05/4 | Accepted: 2015/06/5 | Published: 2015/06/28

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Volume 18, Issue 3 (Iranian South Medical Journal 2015) Back to browse issues page