ISMJ

Background Following initial studies reporting the presence of βeta adrenergic receptors on bone cells, several studies have investigated the role of the Beta adrenergic system in the formation and resorption of bone. The goal of this report was to review the data supporting the role of the  beta adrenergic system and osteo-neuromediators in the regulation of bone homeostasis.

Materials and Methods: In this review, more than 100 published articles were reviewed for the evidence of the adrenergic effect on bone remodeling and focused on the latest advances in this area.

Results: Based on a variety of pharmacologic, genetic and clinical studies focused on b-adrenergic receptor (bAR) signaling in bone cells, The adrenergic activity of the sympathetic nervous system has been shown to be a negative regulator of bone mass; adrenergic signaling inhibits osteoblast proliferation and promotes osteoclastogenesis .

Conclusion: Altogether, these observations and linked findings are of great significance since they improve our understanding of bone physiology., and uncovered new potential therapeutic strategies for the design of bone anabolic drugs. Certainly, knowledge about downstream factors of beta-adrenergic system can be helpful in making decisions about appropriate therapeutic interventions.