Volume 20, Issue 3 (Iranian South Medical Journal 2017)                   Iran South Med J 2017, 20(3): 301-307 | Back to browse issues page

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The Study the Effect of Vitamin D on Hypothyroidism
Afsaneh Talaei * 1, Fariba Ghorbani2 , Parisa Naseri3 , Ali Chehrea4
1- Endocrine and Metabolism Research Center, Arak University of Medical Science, Arak, Iran , afsanehtalaeii@yahoo.com
2- Department of Internal Medicine, School of Medicine, Arak University of Medical Science, Arak, Iran
3- Department of Statistic, School of Medicine, Arak University of Medical Science, Arak, Iran
4- Endocrine and Metabolism Research Center, Arak University of Medical Science, Arak, Iran
Abstract:   (6442 Views)

Background: Vitamin D deficiency or insufficiency is a common worldwide concern. The association between hypothyroidism and vitamin D deficiency is controversial. We aimed to study the effect of vitamin D on thyroid function in hypothyroid patients.
Material and Methods: In this case-control randomized clinical trial study, 201 hypothyroid patients referred to endocrinology clinics in Arak, were randomly classified into two groups.  All patients were taking levothyroxine. Case group received vitamin D 50000 unit weekly and control group received placebo in addition to levothyroxine. After three months, thyroid function tests were repeated and compared with the results of the start of the study. Both intra-groups and inter-groups differences were analyzed by student t-test and paired t-test analysis.
Results: Male/Female ratio in case and control groups were 0.24 and 0.15 respectively (P=0.1). The prevalence of vitamin D deficiency and insufficiency was 68.7 % (138) and 93.5% (188) and after taking vitamin D was 70% (34.8) and 51.2% (103) respectively.Student t-test showed that TSH level in people who received vitamin D had a significant reduction in comparison with the placebo group(P<0.05). There was a significant difference in the change of TSH level between two groups at vitamin D level 10-30 ng/ml.
Conclusion: Most of the hypothyroid patients had vitamin D deficiency and receiving vitamin D improved thyroid function by TSH suppression in these patients. We recommend the screening for vitamin D deficiency in hypothyroid patients. However, more research is required to explain this hypothesis at the molecular level.
 
 

Keywords: Vitamin D, Hypothyroid, effect, TSH
Full-Text [PDF 645 kb]   (10033 Downloads)    
Type of Study: Original | Subject: Disorders of Systemic, Metabolic or Environmental Origin
Received: 2016/04/19 | Accepted: 2017/01/9 | Published: 2017/07/5
References
1. Ross AC, Taylor CL, Yaktine AL, et al. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Washington: National Academies Press, 2011, 3-11.
2. Agmon-Levin N, Theodor E, Segal RM, et al. Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol 2013; 45(2): 256-66. [DOI:10.1007/s12016-012-8342-y]
3. Mangin M, Sinha R, Fincher K. Inflammation and vitamin D: the infection connection. Inflamm Res 2014; 63(10): 803-19. [DOI:10.1007/s00011-014-0755-z]
4. Gouni-Berthold I, Krone W, Berthold HK. Vitamin D and cardiovascular disease. Curr vasc Pharmacol 2009; 7(3): 414-22. [DOI:10.2174/157016109788340686]
5. Hollick MF, Chen TC. Vitamin D deficiency a worldwide problem with health consequences. Am J Clin Nutr 2008; 87(4): 1080S-6S. [DOI:10.1093/ajcn/87.4.1080S]
6. Choi HS, Oh HJ, Choi H, et al. Vitamin D insufficiency in Korea--a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008. J Clin Endocrinol Metab 2011; 96(3): 643-51. [DOI:10.1210/jc.2010-2133]
7. Yasuda T, Okamoto Y, Hamada N, et al. Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease. Endocrine 2012; 42 (3): 739-41. [DOI:10.1007/s12020-012-9679-y]
8. Vitamin D Deficiency and Thyroid Disease. (Accessed at May 30, 2017 at https:// www.goodhormonehealth.com/VitaminD6mar10.pdf)
9. Hong Q, Xu J, Xu S, et al. Associations between serum 25-hydroxyvitamin D and disease activity, inflammatory cytokines and bone loss in patients with rheumatoid arthritis. Rheumatology (Oxford) 2014; 53(11): 1994-2001. [DOI:10.1093/rheumatology/keu173]
10. Holmøy T, Torkildsen Ø, Myhr KM, et al. Vitamin D supplementation and monitoring in multiple sclerosis: who, when and wherefore. Acta Neurol Scand Suppl 2012; (195): 63-9. [DOI:10.1111/ane.12028]
11. Joergensen C, Hovind P, Schmedes A, et al. Vitamin D levels, Microvascular complications and mortality in type 1 diabetes. Diabetes Care 2011; 34(5): 1081-5. [DOI:10.2337/dc10-2459]
12. Vilarrasa N, Vendrell J, Maravall J, et al. Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population. Endocrine 2010; 38(2): 235-42. [DOI:10.1007/s12020-010-9379-4]
13. Robien K, Butler LM, Wang R, et al. Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore. Br J Nutr 2013; 109(3): 493-502. [DOI:10.1017/S0007114512001675]
14. G R, Gupta A. vitamin D deficiency in India: prevalence, causalities and interventions. Nutrients 2014; 6(2): 729-75. [DOI:10.3390/nu6020729]
15. Yamashita H, Noguchi S, Takatsu K, et al. High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease. Endocr J 2001; 48(1): 63-9. [DOI:10.1507/endocrj.48.63]
16. Wang J, Lv S, Chen G, et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients 2015; 7(4): 2485-98. [DOI:10.3390/nu7042485]
17. Tamer G, Arik S, Tamer I, et al. Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid 2011; 21(8): 891-6. [DOI:10.1089/thy.2009.0200]
18. Low Vitamin D Contributes to Thyroid Problems.Richards Byron. Health news 2008. (Accessed May 30, 2017, at http://www.wellnessresources.com/health/articles/low vitamin d contributes to thyroid problems)
19. Mackawy AM, Al-Ayed BM, Al-Rashidi BM. Vitamin D deficiency and its association with thyroid disease. Int J Health Sci (Qassim) 2013; 7(3): 267-75. [DOI:10.12816/0006054]
20. Sar M, Stumpf WE, DeLuca HF. Thyrotropes in the pituitary are target cells for 1,25 dihydroxy vitamin D3. Cell Tissue Res 1980; 209(1): 161-6. [DOI:10.1007/BF00219932]
21. Smith MA, McHenry C, Oslapas R, et al. Altered TSH levels associated with increased serum 1, 25-dihydroxyvitamin D3: a possible link between thyroid and parathyroid disease. Surgery 1989; 106(6): 987-91.
22. Gross HA, Appleman MD, Nicoloff JT. Effect of biologically active steroids on thyroid function in man. J Clin Endocrinol Metab 1971; 33(2): 242-8. [DOI:10.1210/jcem-33-2-242]
23. Kinuta K, Tanaka H, Moriwake T, et al. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology 2000; 141(4): 1317-24. [DOI:10.1210/endo.141.4.7403]
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