:: Volume 20, Number 4 (Iranian South Medical Journal 2017) ::
Iran South Med J 2017, 20(4): 317-325 Back to browse issues page
The Study of the Effect of Levothyroxine on Dysfunctional Uterine Bleeding (DUB) in Euthyroid Women
Mehri Jamilian1, Afsaneh Talaei2, Ali Chehrei *3, Mohammad Reza Rezvanfar2, Fatemeh Rafei4
1- Gynecology Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
2- Endocrinology Depatment, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
3- Pathology Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
4- Statistic Department, Thyroid Disorders Research Center, Arak University of Medical Sciences, Arak, Iran
Abstract:   (109 Views)
Background: Hypothyroidism and hyperthyroidism have been known as the most important reasons for DUB (dysfunctional uterine bleeding) that presents as menstrual irregularities. Regarding to the effects of thyroid hormones on mense, levothyroxine intake may be effective on DUB in euthyroid women.
Material and Methods: In this interventional randomized, double-blind, placebo-controlled clinical trial on 120 women aged 35-55 years old with DUB that they had no organic reasons and had normal thyroid function and they were taking oral contraceptive pill (OCP), were divided in two groups that each group included 60 women. The intervention group took one tablet of levothyroxine 0.1 mg daily and control group took placebo for three months and after 3 months, comparison between two groups were performed by using SPSS software 16 and in order to data analyzing paired t test and student t test and covariance analysis was used.
Results: Our study showed the overall recovery rate of all kinds of mense irregularities was 48(80%) and 51(85%) in intervention and control groups respectively that shows there was no difference in comparison to pretreatment (P=0/47). The comparison of recovery rate based on different kinds of mense irregularities in two groups showed that recovery rate in metrorrhagia was significantly more in intervention group (100%) than control group. Based on covariance analysis, a meaningful recovery rate in duration and interval bleeding, and the number of used pads was seen in intervention group in comparison to control group
(F=4.352, P=0.006).
Keywords: Levothyroxine, DUB, euthyroid, Women
Full-Text [PDF 587 kb]   (95 Downloads)    
Type of Study: Original | Subject: Gynecology
Received: 2017/08/27 | Accepted: 2017/08/27 | Published: 2017/08/27



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Volume 20, Number 4 (Iranian South Medical Journal 2017) Back to browse issues page