:: Volume 20, Issue 4 (Iranian South Medical Journal 2017) ::
Iran South Med J 2017, 20(4): 326-338 Back to browse issues page
on The Study of Herbal Combination Effect of Securigera Securidaca, Vaccinium Arctostaphylos, Citrullus Colocynthis and Coriandrium Sativum on Triglyceride of Pre-Diabetic Elderlies
Zinab Shababi 1, Shahnaz Pouladi * 2, Ali Reza Raeisi 3, Nilofar Motamed 4, Mohammad Reza Farzaneh 3
1- Student Research Committee, School of Nursing and Midwifery, Bushehr University of Medical Sciences, Bushehr, Iran
2- Department of Nursing, School of Nursing and Midwifery, Bushehr University of Medical Sciences, Bushehr, Iran , Sh.pooladi@bpums.ac.ir
3- Department of Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Social Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract:   (935 Views)
Background: Increasing blood sugar and hyperlipidemia in diabetic patients may lead to enhance late complications of diabetes. So, the aim of this study was to evaluate the herbal combination effects of securigera securidaca, vaccinium arctostaphylos, citrullus colocynthis and coriandrium sativum on triglyceride of pre-diabetic elderlies.
Materials and Methods: In a single-blind randomized controlled trial, 60 pre-diabetic persons aged 60 to 70 years with triglyceride level of 180-250 mg/dl were selected. They were divided in two groups (drug and placebo) randomly. The drug group patients recieved diet with 500 mg capsules of herbal blend once a day and the placebo group in the same period received diet and placebo capsules (500 mg flour). Their triglyceride levels in 2 groups were evaluated after 30 days.finally,  SPSS software 18 was used to data analysis.
Results: In this study, comparing the mean triglyceride and the mean changes in triglyceride had no significant statistical diffrences before and after the intervention, also comparing the mean triglyceride levels before and after the intervention, separetly Translation errorin vegetable capsules group (drug) or placebo had no significant statistical diffrences.
Conclusion: Regarding to the ineffectiveness of of 30-day intervention of herbal blend on elderlies’s triglyceride, it is recommended to perform more study regarding to drug dose and time of consumption of these herbal medications.
Keywords: elderly, pre-diabetes, hyperlipidemia, securigera securidaca, vaccinium arctostaphylos, citrullus colocynthis, coriandrium sativum
Full-Text [PDF 760 kb]   (273 Downloads)    
Type of Study: Original | Subject: Disorders of Systemic, Metabolic or Environmental Origin
Received: 2017/08/27 | Accepted: 2017/08/27 | Published: 2017/08/27
1. Totonchi P. Frequency of chronic diseases and disabilities associated with aging characteristics of the elderly under Emam Khomeini Relief Committee of Tehran and its determinants. Payesh Health Monit 2004;3(3): 219-25. (Persian)
2. Zahmatkeshan N, Bagherzadeh R, Akaberian S, et al. Assessing quality of life and related factors in Bushehr’s elders-2009-2010. J Fasa Univ Med Sci 2012; 2(1): 53-8. (Persian) [Google Scholar]
3. Hosseini SR, Zabihi A, Savadkohi S, et al. Prevalence of chronic disease in elderly population Amirkola (2006-2007). J Babol Univ Med Sci 2008; 10(2): 68-75. (Persian) [Google Scholar]
4. Habibi A, Nemadi Vosoughi M, Habibi S, et al. Quality of life and prevalence of chronic illnesses among elderly people: a cross-sectional survey. J Ardabil Univ Med Sci 2012; 3(1): 58-66. (Persian) [Google Scholar]
5. Abbaszadeh Ahrnjany Sh, Tabatabai Mollazi O, Pajouhi M. Diabetes and aging. Iran J Diabetes Lipid Disord 2009; 8(4): 317-30. (Persian)
6. Nassiri S, TaghavianPour S, Sadiqha A. Association of androgenetic alopecia and hyperlipidemia. Iran J Dermatol 2005; 8(32): 266-71. (Persian) [Google Scholar]
7. Yazdani A, Mansourian M, Faghihimani E, et al. The effects of macronutrient intake on the risk of pre-diabetes in first-degree relatives of patients with type 2 diabetes. J Isfahan Med Sch 2014; 32(301): 1475-86. (Persian) [Google Scholar]
8. Esmaiel zadeh M. Effects of hyperlipidemia on left ventricular diastolic function. J Ilam Univ Med Sci 2001; 8-9(29-30): 22-9. (Persian) [Google Scholar]
9. Khalili H, Gholami Kh, Dashti S, et al. Comparison of gemfibrozil and lopid effects on reduction of serum levels of triglyceride and cholesterol in hyperlipedimic patients. J Kerman Univ Med Sci 2007; 14(1): 19-24. (Persian) [Google Scholar]
10. Kazemi T, Panahi Shahri H, Hossaini Farash M, et al. Effect of Dill pearl on serum lipids. J Arak Univ Med Sci 2006; 8(3): 35-41. (Persian) [Google Scholar]
11. Yazdanpanah K. Effect of Dill Juice on Serum Low Density Lipoprotein,Triglycerid and High Density Lipoprotein in Patients With Hyperlipidemia. Sci J Kurdistan Univ Med Sci 2001; 5(3): 1-4. (Persian) [Google Scholar]
12. Roghani M, Baluchnejadmojarad T, Taheri S. The effect of feeding with aerial part of vaccinium myrtillus on blood glucose and lipids of diabetic rats. Iran J Diabetes Lipid Disord 2007; 7(2): 151-8. (Persian) [Google Scholar]
13. Fallah Huseini H, Fakhrzadeh H, Dastpak A, et al. Review of antihyperlipedemic herbal medicine. J Med Plants 2005; 3(15): 9-20. [Google Scholar]
14. Aghili Khorasani M. Makhzan Aladvyeh. In: Mohammad Reza Shams, editor. Tehran: Andisheh Zehour, 2010. (Persian)
15. Emami M, Fasihi Sh, Mehrgan A. Reference books on medicinal plants. Tehran: Andisheh Avar Publication (with cooperation abzh publication, 2010, 364. (Persian)
16. Heidari M, Norouzzadeh R. Medicinal Plants (Nursing and patient education). Tehran: Jamea Negar Publication,2014, 244 (Persian) [Google Scholar]
17. Rajaei Z, Hadjzade M, Moradi R, et al. Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of securigera securidaca seed in streptozotocin-induced diabetic rats. Adv Biomed Res 2015;4(1): 33. [DOI] [PubMed]
18. Fathi Azad F, Allaf Akbari N, Zakheri A, et al. Hypolipidemic and antioxidant effects of Securigera securidaca L. seed in high fat fed rats. J Pharm Sci Tabriz Univ Med Sci 2010; 15(4): 293-301. (Persian) [PubMed] [Google Scholar]
19. Kianbakht S, Hajiaghaee R. Anti-hyperglycemic effects of vaccinium arctostaphylos L. Fruit and leaf extracts in alloxan-induced diabetic rats. J Med Plants 2013; 12(45): 43-50. [PubMed] [Google Scholar]
20. Mahmoodi M, Sayyadi AR, Hosseini Zijoud SM, et al. Survey on the effects of different concentrations of citrullus colocynthis fruit powder on some of the blood biochemical factors in normal and diabetic male rats. J Rafsanjan Univ Med Sci 2012; 11(1): 11-20. (Persian)
21. Ahangarpour A, Oroojan AA. Effect of crust and seed’s aqueous extract and hydro-alcoholic extracts of crust, seed and pulp of citrullus colocynthis on lipid’s factors and hepatic enzyme in fructose-fed male rats. J Babol Univ Med Sci 2012; 14(4): 53-60. (Persian) [Google Scholar]
22. Chitra V, LeelammaS. Coriandrum Sativum changes the levels of lipid peroxidase and activity of antioxidants enzymes in exprimental animals. Indian J Biochem Biophys (IJBB) 1999; 36(1): 59-61. [Google Scholar]
23. Dallak M. In vivo, hypolipidemic and antioxidant effects of Citrullus colocynthis pulp extract in alloxan-induced diabetic rats. Afr J Biotech 2011; 10(48): 9898-903. [Google Scholar]
24. Dhanapakiam P, Joseph JM, Ramaswamy VK, et al. The cholesterol lowering property of coriander seeds (Coriandrum sativum): mechanism of action. J Environ Biol 2008; 29(1): 53-6. [PubMed] [Google Scholar]
25. .Fallah Huseini H, Hooseini P, Heshmat R, et al. The clinical investigation of securigera securidaca (L.) (degen & doerfler) seeds in type II diabetic patients a randomized, double-blind, placebo-controlled study. J Med Plants 2006; 4(20): 75-9. (Persian) [Google Scholar]
26. Hakimi M, Soltani R, Keshvari M, et al. The effects of vaccinium arctostaphylos on lipid profile in mild hyperlipidemia patients- a randomize clinical trial. J Shahrekord Univ Med Sci 2014; 16(5): 92-9. (Persian) [Google Scholar]
27. Rahbar AR, Nabipour I. The hypolipidemic effect of citrullus on patients with hyperlipidemia. Pakistan J Biol Sci 2010; 13(24): 1202-7. [PubMed] [Google Scholar]
28. Aissaoui A, Zizi S, Israili ZH, et al. Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. J Ethnopharmacol 2011; 137(1): 652-61. [PubMed] [Google Scholar]
29. Ahmed S, Anuntiyo J, Malemud CJ, et al. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evidence-Based Complementary and Alternative Medicine (eCAM) 2005; 2(3): 301-8. [PubMed] [Google Scholar]
30. Fallah Huseini H, Zaree A, Heshmat R, et al. The effect of citrullus colocynthis (L.) schrad. fruit on oxidative stress parameters in type II diabetic patients. J Med Plants 2006; 1(17): 55-60. (Persian) [Google Scholar]
31. Mirfeizi M, Mehdizadeh Tourzani Z, Rezvani HR, et al. The effects of whortleberry on controlling of blood glucose and lipids in patients with type II diabetes: A randomized controlled trial. J Army Univ Med Sci IR Iran 2012; 10(3): 225-31. (Persian) [PubMed] [Google Scholar]

XML   Persian Abstract   Print

Volume 20, Issue 4 (Iranian South Medical Journal 2017) Back to browse issues page