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:: Volume 20, Issue 6 (Iranian South Medical Journal 2018) ::
Iran South Med J 2018, 20(6): 540-552 Back to browse issues page
Effect of Hydroalcoholic Extract of Wheat Sprout On Histology and Histometry Structure of Rat's Prostate Exposed to Lead
Hasan Morovvati 1, HamidReza Moradi * 2, Mesam Biabani 1
1- Department of Basic Science, School of Veterinary Medicine, University of Tehran, Tehran- Iran
2- Department of Basic Science, School of Veterinary Medicine, University of Tehran, Tehran- Iran , hmoradi20@yahoo.com
Abstract:   (514 Views)
Background: Toxic elements can seriously affect prostate gland function. Lead is one of the most common toxic materials among these elements. On the other hand, herbal medicine such as wheat sprout can be used to reduce the heavy metal toxicities. This study has investigated the effects of wheat sprout extract on histological and histometrical structure of prostate gland in rats exposed to lead acetate.
Materials and Methods: Thirty rats were divided randomly into six groups: G1 (control group) received 1 ml/kg/day of normal saline, G2 group received 20 mg/kg/day of lead acetate, G3 and G4 groups received 100 mg/kg/day and 200 mg/kg/day of wheat sprout extract respectively, G5 and G6 groups  received mixture of 20 mg/kg/day of lead acetate along with100 mg/kg/dayand 200 mg/kg/day of wheat sprout extract
respectively. After 35 days, rats were euthanized and blood and prostate tissue samples were collected for histomorphological and histochemical studies.
Results: Results showed a significant decrease in epithelial height of secretory units (P= 0.02) and percentage of parenchyma to stroma (P= 0.036) in the lead group (G2), compared to control group. On the contrary, a significant increase was seen in epithelial height in the group receiving wheat sprout extract[G4 (200 mg/kg/day)], compared to control group (P= 0.033). Serum concentration of testosterone and antioxidant activity (AOA) showed a significant decrease in the lead group(G2), compared to control group (P< 0.001).
Conclusion: Wheat sprout extract is effective in the healing process of damaged tissue structure in prostate glands in rats exposed to lead acetate.
Keywords: Wheat sprout, lead, prostate, histology, rat
Full-Text [PDF 1038 kb]   (146 Downloads)    
Type of Study: Original | Subject: Urogenital System
Received: 2018/01/7 | Accepted: 2018/01/7 | Published: 2018/01/7
References
1. Eurell JAC, Frappier BL, Dellmann HD. Dellmann's textbook of veterinary histolo-gy.Ames, Iowa: Blackwel1:, 2006, 249-51.
2. Moradi HR, ErfaniMajd N, Esmaeilzadeh S, et al. The histological and histometrical ef-fects of Urticadioica extract on rat's prostate hyperplasia. VRF 2015; 6(1), 23-9. [PubMed] [Google Scholar]
3. Dorostghoal M, Seyyednejad S, Jabari A. Protective effects of Fumariaparviflora L. on lead‐induced testicular toxicity in male rats. Andrologia 2014; 46(4): 437-46. [PubMed] [Google Scholar]
4. Morovvati H, Moradi HR, Adibmoradi M, et al. wheat sprout effects on Histological and histometrical structure and sperm parameters in testis of rat exposed to lead. JVR2017; 72: 87- 101. (persian). [Google Scholar]
5. Zhu KX, Zhou HM, Qian HF. Comparative study of chemical composition and physicochemical properties of defatted wheat germ flour and its protein isolate. J food bio-chem 2006; 30(3): 329-41. [Google Scholar]
6. Bonfili L, Amici M, Cecarini V, et al. Wheat sprout extract-induced apoptosis in human cancer cells by proteasomes modulation. Bio-chimie 2009; 91(9): 1131-44. [PubMed] [Google Scholar]
7. Kulkarni SD, Tilak JC, Acharya R, et al. Evaluation of the antioxidant activity of wheatgrass (Triticumaestivum L.) as a func-tion of growth under different conditions. PTR 2006; 20(3): 218-27. [PubMed] [Google Scholar]
8. Najafzadeh H, Aghel N, Hemmati A, et al. Effect of hydro alcoholic extract of peel of Punicagranatum on experimental diabetes mellitus by streptozotocin in rats. J Pharm Sci2011; 16(4): 239-48.(Persian) [Google Scholar]
9. Kheradmand A, Alirezaei M, Dezfoulian O. Cadmium-induced oxidative stress in the rat testes: protective effects of betaine. Int J Pept Res Ther 2013; 19(4): 337-44. [Google Scholar]
10. Koracevic D, Koracevic G, Djordjevic V, et al. Method for the measurement of antioxidant activity in human fluids. J ClinPathol 2001; 54(5): 356-61. [PubMed] [Google Scholar]
11. Kumar P, Yadava R, Gollen B, et al. Nutri-tional contents and medicinal properties of wheat: a review. LSMR 2011; 22: 1-10. [Google Scholar]
12. Webber MM. Selenium prevents the growth stimulatory effects of cadmium on human prostatic epithelium. BiochemBiophys Res Commun 1985; 127(3): 871-7. [PubMed] [Google Scholar]
13. Bai XY, Qu X, Jiang X, et al. Association between dietary vitamin c intake and risk of prostate cancer: a meta-analysis involving 103,658 subjects. J Cancer 2015; 6(9): 913-21. [PubMed] [Google Scholar]
14. Vance TM, Su J, Fontham ET, et al. Dietary antioxidants and prostate cancer: a review. Nutr Cancer 2013; 65(6): 793-801. [PubMed] [Google Scholar]
15. Ayinde OC, Ogunnowo S, Ogedegbe RA. Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats. BMC Pharma-colToxicol 2012; 13: 17. [PubMed] [Google Scholar]
16. Doaa M, Ashraf S, Ahmed O, et al. Effect of cadmium on the testes of adult albino rats and the ameliorating effect of zinc and vita-min E. Br J Sci 2014; 11(1): 72-95. [Google Scholar]
17. Arab M R, Mirzaei R, Mashhadi R, et al. Histological study of toxic effects of solder fumes on thickness of germinal epithelium in seminiferous tubule in rat. Iran South Med J. 2014; 17 (4) :612-19. (Persian).
18. Lataillade GP, Manlay AT, Coffigny H, et al. Reproductive toxicity of chronic lead exexposure in male and female mice. Hum Ex-pToxicol 1995; 14(11): 872-8. [PubMed] [Google Scholar]
19. Alvarez SM, Gomez NN, Scardapane L, et al. Effects of chronic exposure to cadmium on prostate lipids and morphology. BioMetals 2007; 20(5): 727–41. [PubMed] [Google Scholar]
20. Alvarez SM, Gomez NN, Scardapane L, et al. Morphological changes and oxidative stress in rat prostate exposed to a non-carcinogenic dose of cadmium. ToxicolLett 2004; 153(3): 365–76. [PubMed] [Google Scholar]
21. Wang C, Liang J, Zhang C, et al. Effect of ascorbic acid and thiamine supplementation at different concentrations on lead toxicity in liver. Ann OccupHyg2007; 51(6): 563-9. [PubMed] [Google Scholar]
22. Flora G, Gupta D, Tiwari A. Toxicity of lead: a review with recent updates. Interdis-cipToxicol 2012; 5 (2): 47-58. [PubMed] [Google Scholar]
23. Wilson MJ, Kaye D, Smith WE, et al. Effect of vitamin E deficiency on the growth and secretory function of the rat prostatic com-plex. ExpMolPatho 2003; 74 (3): 267-75. [PubMed] [Google Scholar]
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Morovvati H, Moradi H, Biabani M. Effect of Hydroalcoholic Extract of Wheat Sprout On Histology and Histometry Structure of Rat's Prostate Exposed to Lead. Iran South Med J. 2018; 20 (6) :540-552
URL: http://ismj.bpums.ac.ir/article-1-905-en.html


Volume 20, Issue 6 (Iranian South Medical Journal 2018) Back to browse issues page
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