:: Volume 21, Issue 4 (Iranian South Medical Journal 2018) ::
Iran South Med J 2018, 21(4): 267-275 Back to browse issues page
The Effects of Resveratrol Supplementation on the Level of Adiponectin and Leptin in Type 2 Diabetic Patients
Iraj Nabipour 1, Ameneh Gorgin2, Nilofar Motamedi3, Najmeh Hajian2, Mostafa Chashmpoosh2, Faramarz Kooshesh4, Ali Movahed5
1- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
2- School of Medicine, Bushehr Universityof Medical Sciences, Bushehr, Iran
3- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Anesthesiology, School of Paramedicine, Bushehr University of Medical Sciences Bushehr, Iran
5- School of Medicine, Bushehr Universityof Medical Sciences, Bushehr, Iran
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract:   (1644 Views)
Background: Resveratrol (RSV), one of the most effective natural polyphenolic compounds synthesized by plants, has antioxidant, anti-inflammation and anti-insulin-resistance properties. Some studies suggest that the mechanism of action of RSV is mainly mediated by the deacetylase Sirt1. However, other studies have shown that RSV plays its role through other metabolic routes such as its stimulatory effect on the secretion of adiponectin. Adiponectin is a hormone that plays an important role in the regulation of insu-lin sensitivity and energy homeostasis. In addition, RSV can control obesity by preventing the develop-ment of central leptin resistance. This study aimed to evaluate the effect of RSV on blood concentration of adiponectin and leptin in patients with type 2 diabetes. Materials and methods: This double-blind randomized clinical trial recruited 51 patients with type II diabetes from a previous study. Patients’ demographics and medical history were recorded in an inter-view. The intervention group received 500 mg RSV capsules twice a day for 45 days while the control group received identical placebo capsules. Blood pressure, weight, BMI, lipid profile, blood levels of adi-ponectin, leptin and liver function tests were measured at baseline. Data were analyzed using descriptive statistics and independent t-test in SPSS 18. Results: There were no differences in the concentration of adiponectin and leptin between the two groups. However, Mann-Whitney test revealed a difference in the concentration of leptin between intervention and control groups (p= 0.025). That is, the blood level of leptin was significantly more in the intervention group. Conclusion: The results of this study suggest that supplementation of 1 g per day of RSV for 45 days has no effect on the blood level of adiponectin and leptin in patients with type 2 diabetes.
Keywords: Resveratrol, leptin, adiponectin, type II diabetes
Full-Text [PDF 654 kb]   (595 Downloads)    
Type of Study: Original | Subject: Disorders of Systemic, Metabolic or Environmental Origin
Received: 2018/09/4 | Accepted: 2018/09/4 | Published: 2018/09/4
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