:: Volume 21, Issue 5 (Iranian South Medical Journal 2018) ::
Iran South Med J 2018, 21(5): 353-361 Back to browse issues page
Relationship of Serum Levels of Vitamin K2 and Osteocalcin with Atherosclerotic Coronary Arteries
Zahra Elyaspour1 , Samad Akbarzadeh2, Darush Iranpour3, Afshar Bargahei1, Nilofar Motemed4, Najmeh Hajian1, Khadejeh Ghasemi3, Ali Movahed 5
1- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- Department of Cardiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Community Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran , amovahed58@gmail.com
Abstract:   (1499 Views)
Background: This study aimed to evaluate the relationship of serum levels of vitamin K2 and osteocalcin with coronary artery plaques in people undergoing angiography.
Materials and Methods: This case-control study enrolled 138 people presenting to Bushehr Heart Center for routine examination. Demographic information of the participants was registered in a standard questionnaire. Before undergoing angiography, 10 ml blood was collected from all the participants and stored at – 80 ˚C until the analysis. After the angiography, those who were found to be normal entered the control group, and those with one or more arteries blocked were placed in the case group. Finally, serum levels of vitamin K2 and osteocalcin were measured in all the samples using ELISA kits.
Results: Serum levels of osteocalcin in the case group were significantly higher than those of the control (P=0.019). There was no difference in K2 levels between the two groups (P=0.84). Moreover, no relationship was found between the osteocalcin levels and the number of blocked arteries and the severity of atherosclerosis (P=0.95). By adjusting age and type 2 diabetes in both groups, a difference was observed in the concentration of osteaocalcin and coronary artery atherosclerosis (P=0.034).
Conclusion: Our results showed that a significant relationship exists between increased concentration of serum osteocalcin and coronary artery atherosclerosis. However, no such a relationship was observed between the serum levels of K2 and atherosclerotic arteries.
Keywords: Osteocalcin, vitamin K2, atherosclerotic coronary arteries, angiography
Full-Text [PDF 738 kb]   (460 Downloads)    
Type of Study: Original | Subject: Cardiovascular System
Received: 2018/11/3 | Accepted: 2018/11/3 | Published: 2018/11/3

1. Taheri Z, Mohammad Amoli M, Tavakoli Bazaz J, et al. Investigating the relationship between RANTES gene and coronary artery disease. Ijdld 2012; 11(1): 107-14.
2. Ebrahimi K, Khadem Vatan K, Salarilak S, et al. Epidemiological features of risk factors occurrence and outcomes of myocardial infraction in patients admitted to hospitalsin west azerbaijan province during the years 2011 and 2012. Urmia Medical Journal 2015; 26 (8): 724-34.
3. Kim K, Lim S, Moon JH, et al. Lower uncarboxylated osteocalcin and higher sclerostin levels are significantly associated with coronary artery disease 2015. Bone 2016; 83: 178-83.
4. Zhang Y, Qi L, Gu W, et al. Relation of serum osteocalcin level to risk of coronary heart disease in Chinese adults. Am J Cardiol 2010; 106(10): 1461-5.
5. Holvik K, Van Schoor NM, Eekhoff EM, et al. Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study. Eur J Endocrinol 2014; 171(2):161-70.
6. Dalmeijer GW, Van Der Schouw YT, Magdeleyns E, et al. The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein. Atherosclerosis 2012; 225(2): 397-402.
7. Choi BH, Joo NS, Kim MJ, et al. Coronary artery calcification is associated with high serum concentration of undercarboxylated osteocalcin in asymptomatic Korean men. Clinical endocrinology 2015 ; 83(3): 320-6.
8. Luo Y, Ma X, Hao Y, et al. Relationship between serum osteocalcin level and carotid intima-media thickness in a metabolically healthy Chinese population. Cardiovasc Diabetol 2015; 14: 82.
9. Reyes-Garcia R, Rozas-Moreno P, Jimenez-Moleon JJ, et al. Relationship between serum levels of osteocalcin and atherosclerotic disease in type 2 diabetes. Diabetes Metab 2012; 38(1): 76-81.
10. Bao Y, Zhou M, Lu Z, et al. Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men. Clinical endocrinology 2011; 75(2): 196-201.
11. Gössl M, Mödder UI, Atkinson EJ, et al. Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. Journal of the American College of Cardiology 2008; 52(16): 1314-25.
12. Gast GC, De Roos NM, Sluijs I, et al. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis 2009; 19(7): 504-10.
13. Van Den Heuvel EG, Van Schoor NM, Lips P, et al. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease. Maturitas 2014; 77(2): 137-41.
14. Chatrou MLL, Winckers K, Hackeng TM, et al. Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists. Blood Rev 2012; 26(4): 155-66.
15. Ikari Y, Torii S, Shioi A, et al. Impact of menaquinone-4 supplementation on coronary artery calcification and arterial stiffness: an open label single arm study. Nutr J 2016; 15(1): 53.
16. Millar SA, Patel H, Anderson S, et al. Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis. Front Endocrinol (Lausanne) 2017; 8: 183.

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Volume 21, Issue 5 (Iranian South Medical Journal 2018) Back to browse issues page