%0 Journal Article %A Pourbehi, Gholamreza %A Kalantarhormozi, Mohammadreza %A Ostovar, Afshin %A Akbarzadeh, Samad %A Assadi, Majid %A Dobaradaran, Sina %A Nabipour, Iraj %A Darabi, Hossean %T The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women %J Iranian South Medical Journal %V 18 %N 2 %U http://ismj.bpums.ac.ir/article-1-687-en.html %R %D 2015 %K IGF-1, chronic inflammation, CRP, cardiovascular diseases, metabolic syndrome, %X Background: Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of this study was to evaluate the association between these biomarkers among postmenopausal women. Materials and Methods: A total of 361 healthy Iranian postmenopausal women were randomly selected in a population-based study. The metabolic syndrome was defined according to NCEP, ATPIII criteria. Circulating hs-CRP and IGF-1 levels were measured by highly specific enzyme-linked immunosorbent assay method. Results: Women with higher than median hs-CRP levels had lower IGF-1 levels, in comparison to women with lower than median hs-CRP levels (p<0.0001). In multiple regression analysis, after adjustment for age and the metabolic syndrome, IGF-1 levels had a significant inverse correlation with circulating hs-CRP levels (β=-0.139, p<0.007). After adjustment for age, body mass index and type 2 diabetes mellitus, IGF-1 levels also showed an inverse correlation with hs-CRP levels (β=-0.130, p<0.014). Conclusion: There is a significant inverse correlation between serum IGF-1 and hs-CRP levels in postmenopausal women. This finding provides evidence of the potential cardioprotective effect of IGF-1 via anti-inflammatory mechanisms. %> http://ismj.bpums.ac.ir/article-1-687-en.pdf %P 421-432 %& 421 %! %9 Original %L A-10-1-45 %+ The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran %G eng %@ 1735-4374 %[ 2015