TY - JOUR T1 - The effect of vitex agnus-castus on mastalgia in women TT - بررسی تأثیر داروی گیاهی ویتاگنوس بر ماستالژی (درد پستان) زنان JF - ISMJ JO - ISMJ VL - 11 IS - 2 UR - http://ismj.bpums.ac.ir/article-1-151-en.html Y1 - 2009 SP - 147 EP - 152 KW - mastalgia KW - Vitex agnus castus KW - prolactin KW - herbal drug N2 - Background: Vitex agnus-castus is a herbal drug with antiprolactin effect and it is effective in premenstrual syndrome and hypermenorrhea. The purpose of this study was to evaluate vitex agnus-castus extract (chaste tree) in comparison with placebo in treating patients with mastalgia, and evaluation of its acceptability and side effects. Methods: In a double-blind, randomized clinical trial, 117 women with mastalgia, aged 15-50 years old, referring to women’s health centers, were divided into two groups. One group (55 patients) received 60 drops of vitex agnus-castus daily for three months and the control group (62 patients) received placebo for the same period of time. Results: By the end of the treatment, 88.4% of the vitex agnus-castus group and 17/7% of the placebo group showed positive response (P=0.0001). vitex agnus-castus was well tolerated and caused no side effects. Conclusion: Vitex agus-castus is an effective herbal drug with few side effects in treating mastalgia and it is well tolerated. M3 ER -