TY - JOUR T1 - Effect of esophageal distention on basal and stimulated gastric acid secretion in rats TT - اثر اتساع مری بر ترشح پایه و تحریک شده اسید معده در موش صحرائی JF - ISMJ JO - ISMJ VL - 9 IS - 2 UR - http://ismj.bpums.ac.ir/article-1-28-en.html Y1 - 2007 SP - 114 EP - 122 KW - esophageal distention KW - gastric acid secretion KW - nitric oxide KW - carbachol KW - histamine KW - vagotomy N2 - Background: It is well established that the esophageal distention leads to gastric relaxation, partly by vago-vagal reflex but till now, the effect of esophageal distention on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of esophageal distention (ED) on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240g) were deprived of food but not water for 24 hrs before the experiments. Under urethane anesthesia (1.2 g/kg, i.p.), animals underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distention and gastric washout and the esophagus was cannulated with a distensible balloon orally to distend esophagus (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distention, carbachol (4 µg/kg, i.p.) or histamine (5 mg/kg, s.c.). Effects of vagotomy, L-NAME (10 mg/kg, i.v.), L-arginine (500 mg/kg, i.p.) and hexamethonium were also investigated. Results: Esophageal distention reduces basal and gastric distention, carbachol and histamine stimulated acid secretion (P M3 ER -