RT - Journal Article T1 - Effect of esophageal distention on basal and stimulated gastric acid secretion in rats JF - ISMJ YR - 2007 JO - ISMJ VO - 9 IS - 2 UR - http://ismj.bpums.ac.ir/article-1-28-en.html SP - 114 EP - 122 K1 - esophageal distention K1 - gastric acid secretion K1 - nitric oxide K1 - carbachol K1 - histamine K1 - vagotomy AB - Background: It is well established that the esophageal distention leads to gastric relaxation, partly by vago-vagal reflex but till now, the effect of esophageal distention on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of esophageal distention (ED) on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240g) were deprived of food but not water for 24 hrs before the experiments. Under urethane anesthesia (1.2 g/kg, i.p.), animals underwent tracheostomy and laparotomy. A catheter was inserted in the stomach through duodenum for gastric distention and gastric washout and the esophagus was cannulated with a distensible balloon orally to distend esophagus (0.3 ml, 10 min). Gastric acid secretion was stimulated by gastric distention, carbachol (4 µg/kg, i.p.) or histamine (5 mg/kg, s.c.). Effects of vagotomy, L-NAME (10 mg/kg, i.v.), L-arginine (500 mg/kg, i.p.) and hexamethonium were also investigated. Results: Esophageal distention reduces basal and gastric distention, carbachol and histamine stimulated acid secretion (P LA eng UL http://ismj.bpums.ac.ir/article-1-28-en.html M3 ER -