@ARTICLE{Shirkani, author = {Rahbari manesh, Ali Akbar and Shirkani, Afshin and Akhtar Khavari, Hooshang and Salamaty, Peyman and }, title = {Efficacy of intramuscular single dose of ceftriaxon versus ten days amoxicillin for treatment of children with acute otitis media}, volume = {10}, number = {1}, abstract ={Background: Ceftriaxone is a prolonged third-generation cephalosporin and its intramuscular single dose can provide the necessary serum level against typical pathogens of acute otitis media up to 72 hours. Methods: In a prospective, randomized clinical trial study, the efficacy of intramuscular single dose of ceftriaxone (50mg/kg/dose) was compared to 10 days amoxicillin (50mg/kg/day, divided 3 time per day) to treat acute otitis media in children. A total of 110 children aged 5 months to 12 years, with uncomplicated acute otitis media were randomly selected to receive either an oral suspension amoxicillin for 10 days or an intramuscular single dose of ceftriaxone. Results: Clinical manifestation and demographic characteristics were similar in both groups. In ceftriaxone group, 48 (88.9%) of 54 cases were recovered completely, and in amoxicilline group, the treatment was successful in 51 (99.1%) of 56 cases (p>0.05). In ceftriaxone, 2 cases and in amoxicilline group, 3 cases developed a skin rash (p>0.05). Conclusion: The efficacy of intramuscular single dose of ceftriaxone (50mg/kg) to treat uncomplicated acute otitis media in children is as effective as amoxicillin (50mg/kg/day, divided 3 times per day). }, URL = {http://ismj.bpums.ac.ir/article-1-5-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-5-en.pdf}, journal = {Iranian South Medical Journal}, doi = {}, year = {2007} }