TY - JOUR T1 - Correlation between serum levels of uric acid with bone turnover markers in postmenopausal women TT - بررسی همبستگی سطح سرمی اسید اوریک با مارکرهای بیوشیمیایی ساخت وساز استخوان در زنان یائسه JF - ISMJ JO - ISMJ VL - 17 IS - 6 UR - http://ismj.bpums.ac.ir/article-1-625-en.html Y1 - 2015 SP - 1090 EP - 1099 KW - uric acid KW - osteocalcin KW - CrossLaps KW - alkaline phosphatase KW - menopause N2 - Background: There is accumulation evidence regarding the protective role of higher serum uric acid in bone loss and osteoprotic fractures. This effect may arise from its antioxidant properties. The main aim of this study was to investigate serum uric acid in relation to bone turnover markers in postmenopausal women. Material and methods: A total of 382 postmenopausal women who participated in a prospective study were selected randomly from Bushehr port. Serum uric acid levels and biochemical markers including serum alkaline phosphatase were measured. Circulating levels of CrossLaps, osteocalcin and hsCRP were also measured by ELISA. Results: Uric acid levels had significant correlation with osteocalcin & alkaline phosphatase. However, no correlation could be found between uric acid and CrossLaps. The correlation between uric acid & osteocalcin (r= 0.25, P=0.0001) & alkaline phosphatase(r=0.12, P=0.019) remained after adjustment with age, BMI & hsCRP. Conclusion: Serum uric acid had a positive and significant correlation with osteoblastic born turnover markers. Hence, the role of uric acid in osteoblastic function should be investigated. M3 ER -