@article{ author = {Rabbani, Ozra and Bargahi, Afshar}, title = {The effect of antiangiogenesis proteins, isolated from shark cartilage, on chick chorioallantoic membrane}, abstract ={Background: Shark cartilage has been considered as a natural anti-angiogenesis material in traditional medicine since long ago, and a broad range of biological functions such as inhibition of endothelial cell adhesion, proliferation, migration and digestion of the extracellular matrix has been reported for it. Because of its widespread therapeutic usage in controlling angiogenesis, we have investigated the antiangiogenesis activity of the shark cartilage proteins, in the present study. Methods: Cartilage proteins were extracted in 100 mM sodium acetate buffer (pH=4.8) containing 4M guanidinium hydrochloride in the presence of protease inhibitors. The extract was then chromatographed on cation and anion exchange columns and the fractions were characterized for angiogenesis properties (like number and thickness of blood vessels, number and severity of bends in accessory vessels and abnormal colour of membrane) using chick chorioallantoic membrane (CAM) assay and gel electrophoresis techniques. Results: The results showed high antiangiogenesis activity of protein fraction A1 extracted from shark cartilage comparing to the controls and other trial groups. Survey on the active protein fraction A1 on gel electrophoresis showed existence of low molecular weight proteins between 14-16 kDa. Conclusion: Shark cartilage has an antiangiogenesis effect. Therefore, considering the importance and increasing needs of novel drugs for angiogenesis-based diseases, further molecular surveys on these angiogenesis proteins are recommended.}, Keywords = {angiogenesis, cartilage, shark, cancer}, volume = {10}, Number = {1}, pages = {1-8}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-1-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-1-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Amirinejad, Roya and Vahdat, Katayoun and Nabipour, Iraj and Jafari, Seyed Mojtaba and Ghajari, Amrollah and hajiHoseini, Reza and Hossainy, Seyed Javad and Zandi, Keyvan and Zafarmand, Mohammad Hadi}, title = {Diagnosis of Leptospirosis in haemorrhagic fever in domestic animals of the Helleh River area in 2004 by polymerase chain reaction (PCR) molecular technique}, abstract ={Background: Leptospirosis is a globally important zoonotic disease with worldwide prevalence, caused by spirochetes from the genus Leptospira. Diagnosis based on serology requires testing of acute and convalescent sera. PCR techniques have high sensitivity and specificity for early diagnosis of this disease. Methods: Sera of all (49 cases) livestock breeders of the Helleh River area and 200 domestic animals were collected after 7-10 days from the outbreak of haemorrhagic fever in domestic animals of the Helleh River area in 2004, following torrential rains and flooded water occurrence in this area, and were tested by PCR based on 16srRNA gene. PCR method was used for 60 sera of livestock breeders from the surroundings villages as the normal control group. The human sera were tested for anti-Leptospiral antibodies using ELISA methods for Leptospira IgM. Results: Leptospiral genomes were detected in 16 cases (32.65%) of livestock breeders and 19 cases (9.5 %) of domestic animals by PCR. But, in the normal control group, Leptospiral genomes were not detected. A number of 15 cases of livestock breeders of Helleh River area were positive for IgM-ELISA. Among the PCR positive cases (16 persons), 10 cases were negative and 6 cases were positive for IgM-ELISA. Conclusion: The haemorrhagic fever in domestic animals of the Helleh River area in Bushehr is recognized to be Leptospirosis. The 16S rRNA-based PCR method can recognize pathogenic Leptospira in clinical samples and provides early decisive diagnosis possibility of active infection.}, Keywords = {leptospirosis; PCR; haemorrhagic fever; domestic animals}, volume = {10}, Number = {1}, pages = {9-18}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-2-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-2-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Daneshmand, Abdolreza and Rasooli, Manoochehr and Kargar, Mohammad and Kyani, Simi}, title = {A survey on bacterial contamination of fresh traditional cheeses with Salmonella spp. and Staphylococcus aureus in Jahrom, Fars Province}, abstract ={Background: Milk serves as an excellent culture medium for growth of several kinds of microorganisms. Thus, during the process of cheese production, some microbial species such as Salmonella spp. and Staphylococcus aureus may contaminate the products. Since traditional cheese (un-pasteurized) is produced in rural and urban regions in south of Iran under non-hygienic conditions, the aim of this study was to investigate the rate of contamination of fresh traditional cheeses with Staphylococcus aureus and Salmonella spp. produced in Jahrom in the south of Iran. Methods: A total of two hundred samples of fresh traditional cheese were collected under sterile and refrigerated condition from urban and rural areas of Jahrom. All samples were evaluated to find microbial contamination using microbiological standard methods. Results: A number of 101 samples (50.5%) were contaminated with Staphylococcus aureus. No sample was contaminated with Salmonella spp. Conclusion: Considering the high contamination rate of this kind of cheese in Iran, its production and distribution should be under-control, and people should be trained about the harmfulness of this product. More studies seem to be necessary to clarify other important agents which can contaminate milk and dairy products, and to determine in which step(s) of production the rate of contamination is higher.}, Keywords = {Salmonella, Staphylococcus aureus, cheese, gastroenteritis}, volume = {10}, Number = {1}, pages = {19-26}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-3-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-3-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Tabib, Seyed masood and Nokani, Khadijeh and Pazoki, Rah}, title = {The effect of Buspirone on symptoms and quality of life in patients with functional dyspepsia}, abstract ={Background: Functional dyspepsia (FD) is a heterogeneous disorder of yet unknown etiology which causes a significant reduction in the quality of life. In this study, we compared the effect of buspirone as an agonist of serotonin 5HT1A receptor with amitriptyline and placebo on improving the symptoms and quality of life in patients with functional dyspepsia. Methods: This study was a double-blinded, randomized controlled clinical trial. Using a sequential sampling, patients with the diagnostic criteria of Rome 2 and normal gastrointestinal findings were selected. The subjects were randomly divided into three therapeutic groups receiving amitriptyline, buspirone, and placebo. We used Nepean Dyspepsia Inde (NDI) to evaluate the quality of life before and after the treatment. Results: The mean age of subjects was 35.38±12.94 years. Symptom and quality of life scores of the three groups were equal at the beginning but at the end of treatment, these scores were different. Buspirone was more effective than both amitriptyline and placebo in reducing the symptom of early satiety. Buspirone showed a better improvement in quality of life compared to placebo. Both Buspirone and amitriptyline were more effective than placebo in decreasing the symptom of epigastric pain. Conclusion: Our study confirmed the positive effect of buspirone on the quality of life and symptoms (like early satiety and abdominal pain) in patients with functional dyspepsia. Since the mechanism of action of buspirone and also the pathophysiology of functional dyspepsia are still unknown, further studies are necessary to clarify every aspect of the disease and therapeutic effects of various treatments on it.}, Keywords = {buspirone, amitriptyline, dyspepsia, quality of life}, volume = {10}, Number = {1}, pages = {27-33}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-4-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-4-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Rahbarimanesh, Ali Akbar and Shirkani, Afshin and AkhtarKhavari, Hooshang and Salamaty, Peym}, title = {Efficacy of intramuscular single dose of ceftriaxon versus ten days amoxicillin for treatment of children with acute otitis media}, abstract ={Background: Ceftriaxone is a prolonged third-generation cephalosporin and its intramuscular single dose can provide the necessary serum level against typical pathogens of acute otitis media up to 72 hours. Methods: In a prospective, randomized clinical trial study, the efficacy of intramuscular single dose of ceftriaxone (50mg/kg/dose) was compared to 10 days amoxicillin (50mg/kg/day, divided 3 time per day) to treat acute otitis media in children. A total of 110 children aged 5 months to 12 years, with uncomplicated acute otitis media were randomly selected to receive either an oral suspension amoxicillin for 10 days or an intramuscular single dose of ceftriaxone. Results: Clinical manifestation and demographic characteristics were similar in both groups. In ceftriaxone group, 48 (88.9%) of 54 cases were recovered completely, and in amoxicilline group, the treatment was successful in 51 (99.1%) of 56 cases (p>0.05). In ceftriaxone, 2 cases and in amoxicilline group, 3 cases developed a skin rash (p>0.05). Conclusion: The efficacy of intramuscular single dose of ceftriaxone (50mg/kg) to treat uncomplicated acute otitis media in children is as effective as amoxicillin (50mg/kg/day, divided 3 times per day).}, Keywords = {ceftriaxone, amoxicillin, acute otitis media, antibiotic}, volume = {10}, Number = {1}, pages = {34-39}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-5-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-5-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {babaAhmadiRezaie, Hossain and Goodarzi, Mohammad taghi and kadkhodaie, Manijeh and Haddadinejad, Shahram and navidiabbaspoor, Ali akbar}, title = {The correlation between adiponectin with blood lipids and body mass index in women with type 2 diabetes}, abstract ={Background: Adiponectin, also called GBP-28, apM1, Adipo Q and Acrp30, is a novel adipose tissue-specific protein. A reduction in adiponectin expression is associated with insulin resistance in some animal models. This study was performed to determine the relationship between adiponectin with blood lipids and body mass index (BMI) in diabetic and healthy women. Methods: We examined serum levels of adiponectin, LDL-cholesterol, HDL-cholesterol, triglyceride and cholesterol in diabetic women (n=28) and healthy women (n=42). Adiponectin was measured by ELISA. We used Spearman coefficient to determine correlation between adiponectin with blood lipids and BMI in two studied groups. Results: We found that there was lower concentration of adiponectin in diabetic women (7.29±1.42 µg/ml) than healthy women (10.29 ± 1.93 µg/ml) (P<0.01) and there was a negative correlation between adiponectin and LDL-cholesterol, triglyceride, total cholesterol and BMI, but a positive correlation was assessed between adiponectin and HDL-cholesterol. Conclusion: This study suggests that adiponectin has antiaterogenic properties and confirms that high adiponectin levels correlate with better lipid profile in women with type 2 diabetes.}, Keywords = {adiponectin, type 2 diabetes, body mass index, cholesterol, triglyceride}, volume = {10}, Number = {1}, pages = {40-45}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-6-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-6-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Mofid, Alireza and Zandieh, Saeid and SeyedAliNaghi, Seyed Ahmad and Yazdani, Tahereh}, title = {Prevalence of erectile dysfunction in Tehranian diabetic men}, abstract ={Background: Erectile dysfunction (ED) is an important impediment to quality of life. Diabetes mellitus is one of the most common causes of ED. In other hand, it has been one of the most neglected complications of diabetes mellitus. Our objective was to study prevalence of ED and its relative factors in diabetetes. Methods: During 2002-2004, 700 diabetic men aged 20-69 years were studied at Sina hospital and Abouzahr Health Center. Patients were screened for erectile dysfunction using the International Index of Erectile Function (IIEF) questionnaire. Results: ED was found in 246 (35.1%) of 700 diabetic men. Prevalence of ED was increased with age from 9.7% in men aged 20-30 years to 35% in those aged over 60 years. Men with type I diabetes reported ED less frequently than did men with type II diabetes (odds ratio=1.6). In comparison with reporting diabetes lasting ≤ 5 years, the odds ratio for ED were 1.5 and 2.2 for subject with diabetes lasting 6-10 and 11-30 years respectively. In comparison to the men with good glycemic control, the odds ratio for ED was 1.6 and 2.07 in the men with fair and poor control, respectively. Conclusion: Erectile dysfunction is common in diabetic Iranian men. Further studies on ED risk factors and relation between ED and other complications of diabetes are warranted.}, Keywords = {diabetes mellitus, erectile dysfunction, microvascular, sexual}, volume = {10}, Number = {1}, pages = {46-53}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-7-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-7-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Shayeghi, Mansooreh and Darabi, Hossain and AbtahiHossaini, Mohammad and Sadeghi, Mohammad and Pakbaz, Forough and Golestane, Seyed Rez}, title = {Assessment of persistence and residue of diazinon and malathion in three rivers (Mond, Shahpour and Dalaky) of Bushehr Province 2004-2005}, abstract ={Background: Water contamination due to insecticides, often generates dangerous results for consumers. Immoderate consumption of insecticides in neighboring farms contaminates rivers. Assessment of residue of phosphorus insecticides which are used in farms near rivers can play a key role in preventing probable poisonings and aquatic ecosystems polution. Methods: In this case control study, water of three permanent rivers in Bushehr province and urban water pipe network of Bushehr city were assessed in different months in 2004-2005 and 216 samples were collected on the whole. In each river,three stations were used for sampling. After the sampling, extraction processes were accomplished using solvents such as: acetone, methylen-chloride and benzene. For detection and measurement of TLC Scanner apparatus was used. Results: Residues of diazinon and malathion were found in water of the three rivers in spring and summer. And in other seasons the rate of residues were very low or zero. The statistical analysis of the results through one-sidedanalysis variance, showed that diazinon and malathion residues in the water of the surveyed rivers in different months had significant difference (p 0.05), while malathion residue was significant (p <0.05). Conclusion: In the first and second months after applying the two insecticides, their residues level in all three rivers of Mond, Shahpour and Dalaky are more than acceptable contamination level, the higher levels belong to diazinon. Precautions must be considered in using the water for drinking purposes and also using aquatic foods which are provided from these rivers.}, Keywords = {diazinon, malathion, insecticide, ecosystem}, volume = {10}, Number = {1}, pages = {54-60}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-8-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-8-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Jafary, Seyed Mojtaba and Pazoki, raha and Mirzaie, kamran and Nabipour, Iraj and Eghbali, Seyed Sajad and Sanjideh, Zahr}, title = {Reference range of serum homocysteine level for the northern Persian Gulf}, abstract ={Background: Homocysteine (Hcy), an intermediate form generated during the metabolism of methionine, is associated with cardiovascular diseases. There is little information available about serum concentration of Hcy in healthy Iranian population. In the present study, we assessed the reference range of serum Hcy level among inhabitants of the northern Persian Gulf. Methods: In the Persian Gulf Healthy Heart Study (PGHHS) which used a multistage, stratified, clustered sampling, we measured fasting serum Hcy level using enzyme immunoassay method with an accuracy limit of 1 µmol/ L. Confounding factors such as smoking, alcohol consumption, drugs and chronic diseases were eliminated. Reference range for homocysteine level was considered between 5 and 95 percentiles. Results: A total of 886 participants (39.3% female, 60.7% male) were evaluated. Mean plasma Hcy level was 14.58 ± 7.29 µmol/ L and was higher in men than women. Reference range for Hcy level was 8.35-31.1 µmol/ L in males and 2.39-24.31 µmol/ L in females. There was no difference among age groups for serum Hcy level. Conclusion: The Hcy level in the northern Persian Gulf general population is high. Since high Hcy level has been shown as a risk factor of cardiovascular diseases in various studies, it is essential to study the reasons of this high level of Hcy in this region.}, Keywords = {homocysteine, cardiovascular, vitamin B12, folic acid}, volume = {10}, Number = {1}, pages = {61-66}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-9-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-9-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Mirzaie, kamran and Zahmatkesh, Soray}, title = {A survey on the Knowledge, Attitude and Practices of dentists in Bushehr Province about HIV/AIDS}, abstract ={Background: Dentists are at high risk of blood borne infections since they are often exposed to blood and other body fluids. This study evaluated knowledge, attitudes and behaviour of dentists in Bushehr Province about HIV/AIDS. Methods: In a cross-sectional study, in the year 2007, all dentists who worked in Bushehr Province were evaluated by a self- administered questionnaire. The questionnaire had 20 items about contact and treatment and 7 items about the practices for reducing infection rates after contact with HIV/AIDS subjects in dentistry. Results: From a total of 101 dentists who were working in Bushehr port, 77 dentists (76.2%) participated in this study. The mean age was 33.52 (± 6.15) and the mean duration of working activity was 7.41 (± 5.24) years. The overall knowledge about HIV infection, transmission ways and attitude towards infection control were low and had no correlation with demographic data. Most dentists believed that they had professional (62.1%) and moral duty (96.1%) to treat HIV positive patients. While gloves and face masks were worn routinely by the majority of the dentists (83.3%, and 89.7%, respectively), but were not always changed between patients (75.5% and 50.0%, respectively, p<0.002). Hand washing was performed by 59.0% of dentists before treatment and by 66.2% after treatment. The practice of recapping needles was common, 94.9% and only 39.5% of them bended the needles after using. Conclusion: Educational programs are needed to improve dentists' skill and knowledge about HIV characteristics, routes of transmission, proper practice of infection control and Universal Precautions for preventing infections.}, Keywords = {dentists, AIDS, blood borne infections, HIV}, volume = {10}, Number = {1}, pages = {67-74}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-10-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-10-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Khosravizadegan, fatemeh and Azizi, Fatemeh and Khosravizadegan, Zahra and Morvaridi, Mohammad Rez}, title = {Demographic and psychologic aspects of domestic violence against women}, abstract ={Background: Domestic violence (DV) against women is often hidden, repeated and prolonged. DV is both a direct and an indirect risk factor for physical and mental health problems, and is associated with increased health care utilization. Husbands' violence against wives not only affects the person and her family, but the society as a whole. Methods: In a cross sectional case series study, 100 women of Bushehr Province with the experience of DV were evaluated in 1999. A questionnaire was filled out by interview. Physical abuse, emotional abuse, and controlling behavior aspects of DV were evaluated. Results: All the subjects had experienced the three types of DV. The duration of DV was more than two years in more than half of the participants. 50.6 % of them had experiences of severe and very severe violence. Social isolation (38%), headache (50%), nightmares (25%), misbehavior with children (39%), and irritability (32%) were the most common sequelae. Being fearful of losing their children (23%), shamed by what is happening to them (19%) and low information level (17%) were the most common reasons that they hid their condition regarding DV. Conclusion: The present study indicates the severity and long duration of domestic violence, including symptoms of physical and psychological diseases, in the studied subjects in Bushehr Province.}, Keywords = {domestic violence, women, emotional abuse, social}, volume = {10}, Number = {1}, pages = {75-81}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-11-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-11-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} } @article{ author = {Ranjbar, darioush and Nabipour, Iraj and Shirveis, Emad and Hashemi, Enayat and Mirzaie, kamr}, title = {A Study on historical-cultural architectural fabric of Bushehr Port an Urban, cultural and sanitary approach}, abstract ={Background: Nowadays ancient cultural historic sites are considered as a local cultural asset. The cultural historic fabric of Bushehr port is one of the most unique historical urban sites which is confronting destruction because of speedy urban development. Therefore, the viewpoints of the historic fabric inhabitants were investigated to map its pathological pattern through a multidisciplinary approach. Methods: In a descriptive cross-sectional study, the viewpoints of the inhabitants in the historic cultural fabric of Bushehr port was assessed, through a questionnaire, using random cluster multistage sampling method. The questionnaire was based on four dimensions including: social, sanitary, urban and cultural heritage. Results: A total of 218 residential units of the historic cultural fabric of Bushehr port were surveyed. A portion of one fifth of the inhabitants were familiar with cultural heritage item, yet more than 60% of them agreed upon a renovation of the historic fabric of Bushehr. Meanwhile, more than 80% of the residents received no facility to renew their houses. Drug abuses were mentioned as the most important factor regarding insecurity (52.8%). The most important prospect of people from the municipality of the historic fabric of Bushehr port was renewal and renovation of the residential units (36.7%) and 24.9% asked for renovation of pathways and alleys. Providing a sewage collecting network and regular daily gathering of garbage were reported as the most important sanitary need by the inhabitants. Conclusion: The inhabitants of historic cultural fabric of Bushehr port are interested in preserving their residential units as a cultural heritage, but sanitary and urban problems such as sewage and garbage collection system and the lack of patronage from the side of responsible organizations for renovating this Iranian historic fabric architecture are the deep problematic points.}, Keywords = {culture, sanitary, urban design, sewage}, volume = {10}, Number = {1}, pages = {82-90}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-12-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-12-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2007} }