ISMJ

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Separation of children from their parents at the time of transfer to operating room commonly cause severe anxiety which can induce undesired physiologic and psychologic Sequalea. For the purpose of sedation different pharmacologic and non pharmacological methods have been used. In the present study in order to achieve this object clonidine, an 2 agonist had been used because of its easy availability tastelessness and oral route of usage. 105 children aged 4-8 with ASA:I, candidate of elective operations were selected and randomly divided into three groups of 35 patients each the control, the clonidine-2 and the clonidine-4. 90 minutes before the expected time of transfer to operation room, 1ml/kg apple juice containing no drugs (control), clonidine 2g/kg (clonidine-2) or clonidine 4g/kg (clonidine-4) were given to the children. The state of sedation before premedication, at 30th, 60th and 90th minutes after premedicaiton, at the time of separation from the parents and anesthesia induction were evaluated. Also discharge readiness time were recorded. Comparison of sedation state showed that oral clonidine (in doses 2g/kg or 4g/kg) improved sedation and 90 minutes after usage only 12.5% of the control group patients, as compared with, 78.3% of the clonidine-2 and 90.5% of the clonidine-4 were drowsy (P<0.001). At the time of separation from the parents, 31.4% of the patients from the clonidine-2 and 42.9% of the clonidine-4 were sleepy-calm. But in the control group no patients had such sedation, but instead 77.1% were combative-crying (P<0.001). In the operating room, 18 patients of the control group were combative-crying, but 22 children of the clonidin-2 and 19 of the clonidine-4 were slightly afraid and could be calmed easily (P<0.001). Discharge readiness time was not different for the three groups (P=0.0864).No statistical differences were detected between clonidine-2 and clonidine-4 patients in any parameters. The effect of oral clonidine in reducing preanesthetic anexity in children is significant and for this purpose we recommend the usage of clonidine 2g/kg in apple juice, 90 minutes before transfer to operation room.

Keywords: children, preanesthetic medication, clonidine, anxiety

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