Volume 6, Issue 2 (Iranian south medical of journals 2004)                   Iran South Med J 2004, 6(2): 97-103 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zandi K, farsangi M H, Nabipour I, Soleimani M, Khajeh K, Sajedi R, et al . Isolation and purification of a novel anticancer 60 K daltons protein from the Persian Gulf sea hare, Aplysia Dactylomela . Iran South Med J 2004; 6 (2) :97-103
URL: http://ismj.bpums.ac.ir/article-1-113-en.html
1- , zandi@dr.com
Abstract:   (16585 Views)
Sea hares have attracted the interest of many workers investigating chemical defense substances. Most of these substances are low molecular weight compounds derived from algal diets. Anticancer effects of a novel protein isolated from purple fluid of A. dactylomela are reported. The purification procedure consisted basically of ammonium sulphate fractionation, ion exchange and ultrafiltration techniques. For cytotoxicity effects, L929, K562, HL60 and NB4 cell lines and MTT assay were used. A protein of 60000 Da of the purple fluid of A. dactylomela had antiproliferative effects on the cell lines it was maximally active at 0.5-1.5 microgram/ml on NB4 cell line. Therefore, the purple fluid of A. dactylomela has a novel antiproliferative agent.
Full-Text [PDF 39 kb]   (2039 Downloads)    
Type of Study: Original | Subject: General
Received: 2009/01/21 | Accepted: 2009/01/21 | Published: 2009/01/21

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | ISMJ

Designed & Developed by : Yektaweb