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:: Volume 23, Issue 5 (Iranian South Medical Journal 2020) ::
Iran South Med J 2020, 23(5): 455-464 Back to browse issues page
Prothrombin Time, an Indicator for Psoriasis Activity: A Case - Control Study
Majid Morovati-Sharifabad 1, Maryam Yahyaie2, Elham Salehi2
1- Department of Basic Sciences, School of Veterinary, Ardakan University, Ardakan, Iran , mmorovati@ardakan.ac.ir
2- Department of Basic Sciences, School of Veterinary, Ardakan University, Ardakan, Iran
Abstract:   (585 Views)
Background: Psoriasis is a common chronic and recurrent inflammatory skin disorder related to the
immune system and characterized by the rapid growth of skin cells. To date, no study has been
conducted on the role of the prothrombin time index in determining the disease activity and the prognosis of these patients. Recognizing the factors influencing the prognosis of this disease can be helpful. The aim of this study was to investigate the plasma levels of prothrombin time measured in patients with psoriasis, its association with the severity of the disease and its comparison with those of healthy people.
Materials and Methods: In this case-control study, we evaluated 20 age- and sex-matched patients with psoriasis and compared them with healthy people. A PASI criterion was used to measure the severity of the disease. In both groups, prothrombin time were assayed using a standard kit.
Results: The results showed prothrombin time in the patients and healthy people were 12.213±0.638 and 12.313±0.423 seconds, respectively. The two groups were not significantly different in terms of prothrombin time. (P=0.562).
Conclusion: This study revealed that prothrombin time were not affected by severity of the disease.
prothrombin time were not significant In the two groups, and cannot serve as a biological marker for
psoriasis activity.Further studies are needed to identify prognostic factors for psoriasis.
Keywords: Psoriasis, prothrombin time, prothrombin, Vitamin K. PSAI
Full-Text [PDF 411 kb]   (173 Downloads)    
Type of Study: Original | Subject: General
Received: 2019/10/28 | Accepted: 2020/07/7 | Published: 2020/11/7
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Morovati-Sharifabad M, Yahyaie M, Salehi E. Prothrombin Time, an Indicator for Psoriasis Activity: A Case - Control Study. Iran South Med J. 2020; 23 (5) :455-464
URL: http://ismj.bpums.ac.ir/article-1-1351-en.html

Volume 23, Issue 5 (Iranian South Medical Journal 2020) Back to browse issues page
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