Volume 23, Issue 6 (Iranian South Medical Journal 2020)
Iran South Med J 2020, 23(6): 528-540 |
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Eskandari P, Pouladi S, Anvaripour A R. The effects of Vitamin C on Inflammatory Markers and Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery in Bushehr Heart Center: A Randomized Controlled Clinical Trial. Iran South Med J 2020; 23 (6) :528-540
URL: http://ismj.bpums.ac.ir/article-1-1373-en.html
URL: http://ismj.bpums.ac.ir/article-1-1373-en.html
1- Department ofAnesthesia Group, School of Paramedical Sciences, Bushehr University of Medical Sciences, Bu-shehr, Iran
2- Department of Nursing Group, School of Nursing and Midwiferi, Bushehr University of Medical Sciences, Bu-shehr, Iran
3- Department of Anesthesiology Group, School of Medicine ,Bushehr University of Medical Sciences, Bushehr, Iran , a.anvari.p@hotmail.com
2- Department of Nursing Group, School of Nursing and Midwiferi, Bushehr University of Medical Sciences, Bu-shehr, Iran
3- Department of Anesthesiology Group, School of Medicine ,Bushehr University of Medical Sciences, Bushehr, Iran , a.anvari.p@hotmail.com
Abstract: (2478 Views)
Background: Coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass pump may cause systemic inflammatory reactions by releasing cytokines which leads to multiple organ failure. Vitamin C has anti-inflammatory and antioxidant properties. The study aimed to determine the effect of vitamin C on inflammatory markers and atrial fibrillation in patients undergoing CABG.
Materials and Methods: In the present single-blind randomized controlled clinical trial, 80 patients were divided to experimental and control groups. The experimental group received vitamin C 2 g IV, and the control group received the same amount (equivalent to 4×5 cc shots) of normal saline IV 10 minutes after induction of anesthesia. Arterial blood samples were taken at specified intervals to assess IL-6 and hsCRP levels. The data were analyzed in SPSS-24.
Results: The changes in IL-6 values at the specific intervals were not statistically significant (P> 0.05). Significant differences were observed in hsCRP levels only 24 hours after CABG. The incidence of atrial fibrillation was not significantly different between the two groups after the intervention.
Conclusion: This study showed that ascorbic acid has no effect on reducing IL6 and hsCRP levels in patients undergoing CABG, and similarly, does not cause a reduction in post-CABG atrial fibrillation.
Materials and Methods: In the present single-blind randomized controlled clinical trial, 80 patients were divided to experimental and control groups. The experimental group received vitamin C 2 g IV, and the control group received the same amount (equivalent to 4×5 cc shots) of normal saline IV 10 minutes after induction of anesthesia. Arterial blood samples were taken at specified intervals to assess IL-6 and hsCRP levels. The data were analyzed in SPSS-24.
Results: The changes in IL-6 values at the specific intervals were not statistically significant (P> 0.05). Significant differences were observed in hsCRP levels only 24 hours after CABG. The incidence of atrial fibrillation was not significantly different between the two groups after the intervention.
Conclusion: This study showed that ascorbic acid has no effect on reducing IL6 and hsCRP levels in patients undergoing CABG, and similarly, does not cause a reduction in post-CABG atrial fibrillation.
Type of Study: Original |
Subject:
Cardiovascular System
Received: 2020/02/10 | Accepted: 2020/10/28 | Published: 2020/12/21
Received: 2020/02/10 | Accepted: 2020/10/28 | Published: 2020/12/21
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