Volume 12, Issue 1 (Iranian south medical Journal 2009)                   Iran South Med J 2009, 12(1): 40-47 | Back to browse issues page

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Niazi A A, Sheikhzadeh A, Danesh K, Alavi Naieni R, Shahryar M, Narouie B. Diagnostic value of pleural fluid adenosine deaminase activity in tuberculosis pleurisy. Iran South Med J 2009; 12 (1) :40-47
URL: http://ismj.bpums.ac.ir/article-1-171-en.html
Diagnostic value of pleural fluid adenosine deaminase activity in tuberculosis pleurisy
Abbas ali Niazi , Abdolsamad Sheikhzadeh * 1, Khalilollah Danesh , Roya Alavi Naieni , Mosayeb Shahryar , Behzad Narouie
1- , vaheid2002005@gmail.com
Abstract:   (13009 Views)
Background: Diagnosis of tuberculosis pleurisies is difficult because of its nonspecific clinical presentation and insufficient traditional diagnostic methods. We investigated the use of adenosine deaminase (ADA) activity in tuberculosis pleurisies. Methods: A number of 85 patients were analyzed with exudative pleural effusions. Using the ROC curve, we determined the optimal cutoff for TB pleurisy. Results: A number of 58 exudative samples were nontuberculous (non-TB) and 27 were tuberculosis (TB). There was statistically significant difference (p<0.0001) between the means of pleural fluid ADA levels among the TB and non-TB populations. The prevalence of TB pleurisy in the studied population was 31%. Using the cutoff point equal to 35 for diagnosing TB effusions the sensitivity and specificity 70.3% and 91.3%, respectively. The positive predictive value (PPV) was 79.1% and the negative predictive value (NPV) was 86.8%. A pleural fluid ADA value <19 IU/L suggests that a tuberculosis effusion is highly unlikely. Conclusion: Pleural fluid total ADA assay is a sensitive and specific test suitable for rapid diagnosis of TB pleurisy.
Keywords: adenosine deaminase, tuberculosis pleurisy, diagnostic value, exudative
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Type of Study: Original | Subject: General
Received: 2008/03/18 | Accepted: 2008/08/20 | Published: 2009/09/19
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