Volume 26, Issue 3 (Iranian South Medical Journal 2024)
Iran South Med J 2024, 26(3): 167-177 |
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Eslaminezhad S, Hojjati M, Moradi F. The Antibacterial and Antioxidant Effects of Polyethylene Oxide Nanofibers Containing Plant Peptide and Copper. Iran South Med J 2024; 26 (3) :167-177
URL: http://ismj.bpums.ac.ir/article-1-1853-en.html
URL: http://ismj.bpums.ac.ir/article-1-1853-en.html
1- Department of Chemical Engineering, School of Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran ,f.moradi1993@gmail.com
2- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran ,
Abstract: (1094 Views)
Background: Wounds are one of the most crucial health issues, especially when they are infected with pathogenic microbes. Nowadays, nanofibers have been designed with antibacterial properties to serve as an effective solution for wound healing.
Materials and Methods: In this research, a polyethylene oxide/copper/peptide nanocomposite was
designed using electrospinning at a ratio of 98/1/1 mg. Then, the characteristics of the nanocomposite were analyzed by scanning electron microscopy (SEM), tensile testing and differential scanning calorimetry (DSC). In addition, the antibacterial properties of the prepared nanofibers were evaluated against standard strains of Staphylococcus aureus and Escherichia coli, and the antioxidant effects of the said composite were evaluated.
Results: The SEM results showed that copper and peptide nanoparticles were well spread on the surface of the polymer and the tensile test results revealed that this sample has relatively high tensile strength. Also, the designed nanocomposite was resistant to heat according to the DSC and had antibacterial effects against standard microbial strains and antioxidant properties.
Conclusion: The results of this study showed that the designed nanofibers can be used as a compound with antimicrobial and antioxidant properties in the healthcare and hygiene industries to produce wound dressings.
Materials and Methods: In this research, a polyethylene oxide/copper/peptide nanocomposite was
designed using electrospinning at a ratio of 98/1/1 mg. Then, the characteristics of the nanocomposite were analyzed by scanning electron microscopy (SEM), tensile testing and differential scanning calorimetry (DSC). In addition, the antibacterial properties of the prepared nanofibers were evaluated against standard strains of Staphylococcus aureus and Escherichia coli, and the antioxidant effects of the said composite were evaluated.
Results: The SEM results showed that copper and peptide nanoparticles were well spread on the surface of the polymer and the tensile test results revealed that this sample has relatively high tensile strength. Also, the designed nanocomposite was resistant to heat according to the DSC and had antibacterial effects against standard microbial strains and antioxidant properties.
Conclusion: The results of this study showed that the designed nanofibers can be used as a compound with antimicrobial and antioxidant properties in the healthcare and hygiene industries to produce wound dressings.
Type of Study: Original |
Subject:
General
Received: 2023/12/3 | Accepted: 2024/01/8 | Published: 2024/02/26
Received: 2023/12/3 | Accepted: 2024/01/8 | Published: 2024/02/26
References
1. Sen CK. Human wound and its burden. updated 2020 compendium of estimates. Adv wound care (New Rochelle) 2021; 10(5): 281-92. [DOI]
2. Ahangar P, Woodward M, Cowin AJ. Advanced wound therapies. WPR 2018; 26(2): 58-68. [Article]
3. Kalpana VN, Kataru BA, Sravani N, et al. Biosynthesis of zinc oxide nanoparticles using culture filtrates of Aspergillus niger: Antimicrobial textiles and dye degradation studies. OpenNano 2018; 3: 48-55. [DOI]
4. Jin L, Zhou F, Wu S, et al. Development of novel segmented-pie microfibers from coppercarbon nanoparticles and polyamide composite for antimicrobial textiles application. Text Res J 2022; 92(1-2): 3-14. [DOI]
5. Coradi M, Zanetti M, Valério A, et al. Production of antimicrobial textiles by cotton fabric functionalization and pectinolytic enzyme immobilization. Mater chem phys 2018; 208: 28-34. [DOI]
6. Weinberg SE, Villedieu A, Bagdasarian N, et al. Control and management of multidrug resistant Acinetobacter baumannii: A review of the evidence and proposal of novel approaches. Infect Prev Pract 2020; 2(3): 100077. [DOI]
7. Vereshchagin AN, Frolov NA, Egorova KS, et al. Quaternary ammonium compounds (QACs) and ionic liquids (ILs) as biocides: From Simple Antiseptics to Tunable Antimicrobials. Int J Mol Sci 2021; 22(13): 6793. [DOI]
8. Amini SM. Preparation of antimicrobial metallic nanoparticles with bioactive compounds. Mater Sci Eng C Mater Biol Appl 2019; 103: 109809. [DOI]
9. Li J, Hu S, Jian W, et al. Plant antimicrobial peptides: structures, functions, and applications. Bot Stud 2021; 62(1): 5. [DOI]
10. Srivastava S, Dashora K, Ameta KL, et al. Cysteine‐rich antimicrobial peptides from plants: The future of antimicrobial therapy. Phytother Res 2021; 35(1): 256-77. [DOI]
11. Tang SS, Prodhan ZH, Biswas SK, et al. Antimicrobial peptides from different plant sources: Isolation, characterisation, and purification. Phytochemistry 2018; 154: 94-105. [DOI]
12. Nisar P, Ali N, Rahman L, et al. Antimicrobial activities of biologically synthesized metal nanoparticles: an insight into the mechanism of action. J Biol Inorg Chem 2019; 24(7): 929-41. [DOI]
13. Sánchez-López E, Gomes D, Esteruelas G, et al. Metal-based nanoparticles as antimicrobial agents: An Overview. Nanomaterials (Basel) 2020; 10(2): 292. [DOI]
14. Tortella G, Rubilar O, Fincheira P, et al. Bactericidal and virucidal activities of biogenic metal-based nanoparticles: Advances and Perspectives. Antibiotics (Basel) 2021; 10(7): 783. [DOI]
15. Rojas B, Soto N, Villalba M, et al. Antibacterial activity of copper nanoparticles (Cunps) against a resistant calcium hydroxide multispecies endodontic biofilm. Nanomaterials (Basel) 2021; 11(9): 2254. [DOI]
16. Maleki Dizaj S, Sharifi S, Jahangiri A. Electrospun nanofibers as versatile platform in antimicrobial delivery: current state and perspectives. Pharm Dev Technol 2019; 24(10): 1187-99. [DOI]
17. Hong J, Yeo M, Yang GH, et al. Cell-electrospinning and its application for tissue engineering. Int J Mol Sci 2019; 20(24): 6208. [DOI]
18. Li H, Chen X, Lu W, et al. Application of electrospinning in antibacterial field. Nanomaterials (Basel) 2021; 11(7): 1822. [DOI]
19. Akbari Z, Ansari I, Karimi Z, et al. Repeated Daily Normobaric Hyperoxia: A Non-Pharmacological Strategy Against Gentamicin-Induced Nephrotoxicity. Iran South Med J 2023; 26(2): 77-91. [Article]
20. Aavani F, Khorshidi S, Karkhaneh A. A concise review on drug-loaded electrospun nanofibres as promising wound dressings. J Med Eng Technol 2019; 43(1): 38-47. [DOI]
21. Singh YP, Dasgupta S, Nayar S, et al. Optimization of electrospinning process & parameters for producing defect-free chitosan/polyethylene oxide nanofibers for bone tissue engineering. J Biomater Sci Polym Ed 2020; 31(6): 781-803. [DOI]
22. Eskitoros-Togay ŞM, Bulbul YE, Tort S, et al. Fabrication of doxycycline-loaded electrospun PCL/PEO membranes for a potential drug delivery system. Int J Pharm 2019; 565: 83-94. [DOI]
23. Ibrahim HM, Klingner A. A review on electrospun polymeric nanofibers: Production parameters and potential applications. Polym Test 2020; 90(8): 106647. [DOI]
24. Liu Z, Ramakrishna S, Liu X. Electrospinning and emerging healthcare and medicine possibilities. APL Bioeng 2020; 4(3): 030901. [DOI]
25. Bhattarai RS, Bachu RD, Boddu SHS, et al. Biomedical applications of electrospun nanofibers: Drug and Nanoparticle Delivery. Pharmaceutics 2018; 11(1): 5. [DOI]
26. Luraghi A, Peri F, Moroni L. Electrospinning for drug delivery application: A review. J Control Release 2021; 334: 463-84. [DOI]
27. Yan B, Zhang Y, Li Z, et al. Electrospun nanofibrous membrane for biomedical application. SN Appl Sci 2022; 4(6): 172. [DOI]
28. Moradi F, Mohammadi S, Kakian F, et al. Investigating the Prevalence and Clinical Significance of Helicobacter pylori in Hospital-ized Patients Undergoing Endoscopy in Namazi Hospital, Shiraz. Iran South Med J 2023; 26(2): 102-113. [Article]
29. Niazi AA, Nemati A, Alavi Naeini R, et al. Comparing the Serum Level of Vascular Endothelial Growth Factor (VEGF) in Patients with Active Pulmonary Tuberculosis and the Control Group: A Case Control Study. Iran South Med J 2023; 26(2): 92-101. [Article]
30. Mao Y, Zhang Z, Zeng W, et al. A clinical study of efficacy of polyglycolic acid patch in surgery for pneumothorax: a systematic review and meta-analysis. J Cardiothorac Surg 2020; 15(1): 117. [DOI]
31. Alavi M, Rai M. Recent advances in antibacterial applications of metal nanoparticles (MNPs) and metal nanocomposites (MNCs) against multidrug-resistant (MDR) bacteria. Expert Rev Anti Infect Ther 2019; 17(6): 419-28. [DOI]
32. Sepahvand R, Adeli M, Astinchap B, et al. New nanocomposites containing metal nanoparticles, carbon nanotube and polymer. J Nanopart Res 2008; 10(8): 1309-18. [DOI]
33. Preethi S, Abarna K, Nithyasri M, et al. Synthesis and characterization of chitosan/zinc oxide nanocomposite for antibacterial activity onto cotton fabrics and dye degradation applications. Int J Biol Macromol 2020; 164: 2779-87. [DOI]
34. Sadeghianmaryan A, Yazdanpanah Z, Soltani YA, et al. Curcumin‐loaded electrospun polycaprolactone/montmorillonite nanocomposite: Wound Dressing Application with Anti‐Bacterial and Low Cell Toxicity Properties. J Biomater Sci Polym Ed 2020; 31(2): 169-87. [DOI]
35. Thomas R, Soumya KR, Mathew J, et al. Electrospun polycaprolactone membrane incorporated with biosynthesized silver nanoparticles as effective wound dressing material. Appl Biochem Biotechnol 2015; 176(8): 2213-24. [DOI]
36. Sharaf SS, El-Shafei AM, Refaie R, et al. Antibacterial and wound healing properties of cellulose acetate electrospun nanofibers loaded with bioactive glass nanoparticles; in-vivo study. Cellulose 2022; 29(8): 4565-77. [DOI]
37. Ali IH, Ouf A, Elshishiny F, et al. Antimicrobial and wound-healing activities of graphene-reinforced electrospun chitosan/gelatin nanofibrous nanocomposite scaffolds. ACS omega 2022; 7(2): 1838-50. [DOI]
38. Ahmadian S, Ghorbani M, Mahmoodzadeh F. Silver sulfadiazine-loaded electrospun ethyl cellulose/polylactic acid/collagen nanofibrous mats with antibacterial properties for wound healing. Int J Biol Macromol 2020; 162: 1555-65. [DOI]
39. Sethuram L, Thomas J, Mukherjee A, et al. Eugenol micro-emulsion reinforced with silver nanocomposite electrospun mats for wound dressing strategies. Adv Mater 2021; 2(9): 2971-88. [Article]
40. Kohsari I, Shariatinia Z, Pourmortazavi SM. Antibacterial electrospun chitosan-polyethylene oxide nanocomposite mats containing ZIF-8 nanoparticles. Int J Biol Macromol 2016; 91: 778-88. [DOI]
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