Background: Dermatophytosis or ring worm is one of the most common fungal infections. Trichophyton verrucosum (T.verrucosum) is common among the agents that cause dermatophytosis. The aim of the present study was to evaluate of antifungal activity of copper chloride (cucl2) and 8- hydroxyquinolin compound on T.verrucosum. Methods: One standard strain and two clinical isolated of T.verrucosum were used in this study. The standardized method, M-38 A for filamentous fungi, was used according to the guidelines of National Committee for Clinical and Laboratory Standards (NCCLS) to determine MIC. The effect of CuCl2 and 8-Hydroxyquinolin investigated by using various concentrations of this compound in T.verrucosum cultures. Results: Cucl2 and 8-Hydroxyquinolin compound exhibited antifungal activity on the three mentioned strains and the MIC of this compound was 25μg/ml. Conclusion: Cutaneous The new antifungal drug scheming is required to discover new antifungal agent. The data showed that Cucl2 and 8-Hydroxyquinolin compound had antifungal effect, so they could be a good candidate for making of new antifungal compounds.

Keywords: dermatophyte, Trichophyton verrucosum, antifungal, CuCl2, 8-Hydroxyquinolin

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