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:: Volume 15, Issue 1 (Iranian South Medical of Journal 2012) ::
Iran South Med J 2012, 15(1): 13-24 Back to browse issues page
Investigation on the anti- inflammatory and analgesic effects of Olea europaea L. metanolic extract on male NMRI mouse
Elaheh Tekye1, Sara Moghadam nia2, Akram Eidi2, Reza Taghizadfarid3, Roohollah Ferdosi4, Jalal Zarringhalam 5
1- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IRAN
2- Faculty of Basic Sciences, Islamic Azad University, Science and Research Branch, Tehran, IRAN
3- Institute of Medicinal Plants, ACECR, Tehran, IRAN
4- Research Institute of Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, IRAN
5- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IRAN , jzaringhalam@yahoo.com
Abstract:   (12115 Views)

Background: Different mediators are involved in pain and edema induction during different stages of inflammation. Then, treatment of them encounters some difficulties. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory effects. This study was aimed to investigate anti-inflammatory and analgesic effects of Olea europaea L.methanolic extract on male NMRI mouse. Methods: Methanolic extraction was done for leaf of Olea europaea L. and different doses (200, 300 and 400 mg/kg) were intraperitoneally (i.p.) adminstered to male NMRI mice. Analgesic and anti-inflammatory effects of extract was measured during both phases of Formalin test, Acetic acid induced visceral pain and xylene inflammation tests. A standard analgesic and anti-inflammatory drug such as indomethacin, dexamethasone and morphine were administered in positive control groups where appropriates. Results: Results indicated significant dose-dependent analgesic and anti-inflammatory effects of methanolic extract of Olea europaea L. leaf on pain which induced by formalin (both phase) and acetic acid, and inflammation caused by xylene. Conclusion: Our findings Showed that administration of methanolic extract of Olea europaea L.leaf can suppress pain and inflammation dose dependently which, may mediate via different components of extract. However, more investigations need to be done.

Keywords: Olea europaea L., pain, inflammation, free radicals
Full-Text [PDF 302 kb]   (2175 Downloads)    
Type of Study: Original | Subject: General
Received: 2010/11/4 | Accepted: 2011/03/2 | Published: 2012/01/16
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Tekye E, Moghadam nia S, Eidi A, Taghizadfarid R, Ferdosi R, Zarringhalam J. Investigation on the anti- inflammatory and analgesic effects of Olea europaea L. metanolic extract on male NMRI mouse. Iran South Med J. 2012; 15 (1) :13-24
URL: http://ismj.bpums.ac.ir/article-1-309-en.html


Volume 15, Issue 1 (Iranian South Medical of Journal 2012) Back to browse issues page
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