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:: Volume 16, Issue 3 (Iranian South Medical Journal 2013) ::
Iran South Med J 2013, 16(3): 198-206 Back to browse issues page
Association of estrogen receptor α-351 and -397 polymorphisms with uterine leiomyoma in Chaharmahal & Bakhtiari women
Fatemeh Taghizade Mortezaee, Sepideh Miraj 1, Golandam Bani Talebi, Morteza Hashemzadeh Chaleshtori, Faramarz Sedgh Azar, Maryam Haj Hashemi
1- , sepidehmiraj@skums.ac.ir
Abstract:   (8969 Views)

Background: Uterine leiomyoma, usually known as fibroma, is common estrogen-related a gynaecological disease and the most common disorder leading to hysterectomy. It is estimated that one in four women will develop this kind of benign neoplasia during their reproductive period, therefore, it is considered to have significant effect women’s health. This study aimed to evaluate association of estrogen receptor a (ERα)-351 A>G (XbaI) and -397 T>C (PvuII) gene polymorphisms with uterne leiomyoma in Chaharmahal & Bakhtiari’s women. Material and Methods: 156 women with clinically diagnosed uterine leiomyoma and 151 healthy, normal women were included in this case – control study. ERα-351 A/G XbaI and -397 T/C PvuII polymorphisms were assessed by the method of PCR-RFLP. Collected data were analyzed by SPSS ver.17 software, using chi square tests. Results: Genotypes and allelic frequencies in each group were compared. The genotype/allele frequencies of Era -351 A>G and -397 T/C polymorphisms in leiomyoma groups were not different from those of normal controls sinificantly. Conclusion: We concluded that ERα -351 XbaI A>G and -397 PvuII T>C related genotypes/alleles were not associated with an increased risk of uterine leiomyoma in study population.

Keywords: estrogen a receptor, leiomyoma, polymorphism, estrogen
Full-Text [PDF 443 kb]   (2323 Downloads)    
Type of Study: Original | Subject: General
Received: 2011/05/21 | Accepted: 2011/10/9 | Published: 2013/07/16
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Taghizade Mortezaee F, Miraj S, Bani Talebi G, Hashemzadeh Chaleshtori M, Sedgh Azar F, Haj Hashemi M. Association of estrogen receptor α-351 and -397 polymorphisms with uterine leiomyoma in Chaharmahal & Bakhtiari women. Iran South Med J. 2013; 16 (3) :198-206
URL: http://ismj.bpums.ac.ir/article-1-443-en.html


Volume 16, Issue 3 (Iranian South Medical Journal 2013) Back to browse issues page
دانشگاه علوم پزشکی بوشهر، طب جنوب ISMJ

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