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:: Volume 17, Issue 2 (Iranian South Medical journal 2014) ::
Iran South Med J 2014, 17(2): 173-181 Back to browse issues page
Effect of ciprofloxacin in rat spermatogenesis
Arash Khaki 1, Iraj Sohrabi Haghdoust2, Marefat Ghaffari Novin3, Yadollah Azarmi4, Mahnaz Heidari3
1- Department of Pathology, Faculty of Veterinary Medicine Sciences, Tehran Sciences and Research Branch, Islamic Azad University, Tehran, IRAN , arashkhaki@yahoo.com
2- Department of Pathology, Faculty of Veterinary Medicine Sciences, Tehran Sciences and Research Branch, Islamic Azad University, Tehran, IRAN
3- Department of Pathology, Ibne Sina Institute, Shahid Beheshti University, Tehran, IRAN
4- Department of Pharmacology, School of Pharmacy, Tabriz University of Medical sciences, Tabriz, IRAN
Abstract:   (6322 Views)

Background: Ciprofloxacin is a synthetic antibacterial agent belonging to the family offluoroquinoloneswith a very broad spectrum against of microbial pathogens, especially Gram-negative infectious diseases, that has been approved in more world-widecountries. The aim of this study was planned to seeeffects of ciprofloxacin after inducement, in rat Spermatogenesis. Material and Methods: The twenty male wistar rat were selected and randomly divided into two groups control (n=10) and test (n=10). The test group was received 12.5mg/kg (PO) ciprofloxacin daily for sixty day however the control group just received plate. In sixtieth day the testis tissue of Rat in both groups were remove and prepared for histomorphomotric study and 5cc blood samples were taken for Testosterone analysis. Results: Light microscopic observation, Score count study in seminiferous tubules confirmed most of tubules were in Score2, Score4-5, Score 6-9, and these scoreswere significantly in P<(0.05), and this results confirmed tubular, Sertoli cells syndrome, hypospermatogenisis in experimental group ,in other hand most seminiferous tubules in control group was significantly in Score 10 P<(0.05), and this dataconfirmed intake tubules. There was a marked decrease in serum testosterone hormone, in experimental group as compared with control group, the statically analysis was fishers method (P<0.05). Conclusion: Since in our study ciprofloxacin had decreasing side effect on Spermatogenesis developmentin rat, it was suggested that using ciprofloxacin maybe cause harmful effects on seminiferous tubular.

Keywords: ciprofloxacin, seminiferous tubules development, testosterone, spermatogenesis
Full-Text [PDF 486 kb]   (1826 Downloads)    
Type of Study: Original | Subject: General
Received: 2005/04/6 | Accepted: 2005/05/24 | Published: 2014/04/14
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Khaki A, Sohrabi Haghdoust I, Ghaffari Novin M, Azarmi Y, Heidari M. Effect of ciprofloxacin in rat spermatogenesis. Iran South Med J. 2014; 17 (2) :173-181
URL: http://ismj.bpums.ac.ir/article-1-523-en.html

Volume 17, Issue 2 (Iranian South Medical journal 2014) Back to browse issues page
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