Volume 8, Issue 1 (Iranian south medical of journals 2005)                   Iran South Med J 2005, 8(1): 8-14 | Back to browse issues page

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Shariati M, Khaksary Haddad M, Jafari H, Bahadoran M. Effect of dietary fish oil and corn oil on blood biochemical factors in diabetic Rat. Iran South Med J 2005; 8 (1) :8-14
URL: http://ismj.bpums.ac.ir/article-1-53-en.html
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Abstract:   (18503 Views)
Background: The potential role of omega – 3 (ω-3) and omega-6 (ω-6) fatty acids on blood biochemical factors are in interest and controversy. Some experiences showed that omega – 3 (ω-3) and omega-6 (ω-6) fatty acids have a potential effect on triglyceride, LDL-cholesterol, HDL-cholesterol and total cholesterol levels in diabetes mellitus. Methods: Male rats were divided into four groups (one normal group and three diabetic groups). Induction of diabetes was done by streptozotocin [50mg/kg, s.c. (STZ)]. In diabetic groups, one group was Control, received STZ alone, and the other diabetic groups were fed with fish oil or corn oil for 8 weeks after 4 weeks of induction of diabetes. Plasma glucose, total cholesterol, triglyceride, LDL- choleserol and HDL-cholesterol were measured at 4 and 8 weeks after intervention. Results: Fish oil and corn oil diets had an inhibitory effect on increased plasma glucose in diabetic rat by 46.8% and 40.7%, respectively. Diabetic rats in the control group demonstrated increased plasma total cholesterol, triglyceride and LDL-cholesterol levels, but plasma total cholesterol, triglyceride and LDL-cholesterol levels were significantly decreased and HDL-cholesterol level was increased by both diets in interventional groups. Conclusion: Corn oil and fish oil supplementation have a role on plasma glucose and lipid profile in diabetic rats. To understand the functional mechanisms of these diets, further studies remain to be accomplished.
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Type of Study: Original | Subject: General
Received: 2005/02/19 | Accepted: 2005/09/6 | Published: 2009/01/14

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