:: Volume 10, Issue 1 (Vol. 10, No. 1, September 2007 2007) ::
Iran South Med J 2007, 10(1): 40-45 Back to browse issues page
The correlation between adiponectin with blood lipids and body mass index in women with type 2 diabetes
Hossain Baba Ahmadi Rezaie, Mohammad taghi Goodarzi1, Manijeh Kadkhodaie, Shahram Haddadi nejad, Ali akbar Navidi abbaspoor
1- , mtgoodarzi@yahoo.com
Abstract:   (15280 Views)
Background: Adiponectin, also called GBP-28, apM1, Adipo Q and Acrp30, is a novel adipose tissue-specific protein. A reduction in adiponectin expression is associated with insulin resistance in some animal models. This study was performed to determine the relationship between adiponectin with blood lipids and body mass index (BMI) in diabetic and healthy women. Methods: We examined serum levels of adiponectin, LDL-cholesterol, HDL-cholesterol, triglyceride and cholesterol in diabetic women (n=28) and healthy women (n=42). Adiponectin was measured by ELISA. We used Spearman coefficient to determine correlation between adiponectin with blood lipids and BMI in two studied groups. Results: We found that there was lower concentration of adiponectin in diabetic women (7.29±1.42 µg/ml) than healthy women (10.29 ± 1.93 µg/ml) (P<0.01) and there was a negative correlation between adiponectin and LDL-cholesterol, triglyceride, total cholesterol and BMI, but a positive correlation was assessed between adiponectin and HDL-cholesterol. Conclusion: This study suggests that adiponectin has antiaterogenic properties and confirms that high adiponectin levels correlate with better lipid profile in women with type 2 diabetes.
Keywords: adiponectin, type 2 diabetes, body mass index, cholesterol, triglyceride
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Type of Study: Original | Subject: General
Received: 2006/07/2 | Accepted: 2007/05/6 | Published: 2008/09/4


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Volume 10, Issue 1 (Vol. 10, No. 1, September 2007 2007) Back to browse issues page