:: Volume 18, Issue 2 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(2): 270-279 Back to browse issues page
The study of the effect of the extract Berberis Vulgaris root on serum levels of thyroid hormones in hypercholesterolemia rats
Ali Zarei1, Sohela Taheri2, Saeed Changizi Ashtiyani3, Azam Rezaei4
1- Young Researchers and Elite Club, Abadeh Branch, Islamic Azad University, Abadeh, Iran
2- Education Development Center, Arak University of Medical Sciences, Arak, Iran
3- Department of Physiology, Paramedical Faculty, Arak University of Medical Sciences, Arak, Iran , dr.ashtiyani@arakmu.ac.ir
4- Department of Biology, Basic Science Faculty, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Abstract:   (6797 Views)

Background: The thyroid gland secrete the hormone thyroxin (T4) and triiodothyronine (T3). They have a profound effect on the metabolism of hormones. The aim of this study was to servey the effect of the extract of plant root barberry on the amount of thyroid hormone in rat having hypercholesterolemia. Materials and Methods: In this experimental study, 40 Wistar rats were divided into 5 groups (n=8). Control group with normal diet, fat diet group and other groups, the experimental group received the same diet plus fat hydroalcoholic root extract of barberry maximum dose (300), The mean dose of (150), and a minimum dose of (75 mg/kgw) intraperitoneally injection were divided. After the end of this period (21 days), blood sampling and measurement of sample information were analyzed by using the t and Tukey test, and using of SPSS software version 11.5. Results: The results of statistical tests in the receiving groups extract reflects an increased amount of thyroid hormones T3 and T4 (P<0.05). The level of TSH in groups receiving the extract did not show significant changes Conclusion: Increases in T3 and T4 levels with no changes in TSH concentration indicate euthyroid hyperthyroxinemia probably.

Keywords: Thyroid Hormones, Berberis Vulgaris, cholesterol, Rat
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Type of Study: Original | Subject: Endocrine System
Received: 2013/07/19 | Accepted: 2013/12/1 | Published: 2015/05/3

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Volume 18, Issue 2 (Iranian South Medical Journal 2015) Back to browse issues page