:: Volume 18, Issue 2 (Iranian South Medical Journal 2015) ::
Iran South Med J 2015, 18(2): 421-432 Back to browse issues page
The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women
Gholamreza Pourbehi1, Mohammadreza Kalantarhormozi1, Afshin Ostovar1, Samad Akbarzadeh1, Majid Assadi2, Sina Dobaradaran3, Iraj Nabipour4, Hossean Darabi5
1- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
2- The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
3- Systems Environmental Health, Oil, Gas and Energy Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
4- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
5- The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran , darabi53@yahoo.com
Abstract:   (4278 Views)

Background: Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of this study was to evaluate the association between these biomarkers among postmenopausal women. Materials and Methods: A total of 361 healthy Iranian postmenopausal women were randomly selected in a population-based study. The metabolic syndrome was defined according to NCEP, ATPIII criteria. Circulating hs-CRP and IGF-1 levels were measured by highly specific enzyme-linked immunosorbent assay method. Results: Women with higher than median hs-CRP levels had lower IGF-1 levels, in comparison to women with lower than median hs-CRP levels (p<0.0001). In multiple regression analysis, after adjustment for age and the metabolic syndrome, IGF-1 levels had a significant inverse correlation with circulating hs-CRP levels (β=-0.139, p<0.007). After adjustment for age, body mass index and type 2 diabetes mellitus, IGF-1 levels also showed an inverse correlation with hs-CRP levels (β=-0.130, p<0.014). Conclusion: There is a significant inverse correlation between serum IGF-1 and hs-CRP levels in postmenopausal women. This finding provides evidence of the potential cardioprotective effect of IGF-1 via anti-inflammatory mechanisms.

Keywords: IGF-1, chronic inflammation, CRP, cardiovascular diseases, metabolic syndrome
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Type of Study: Original | Subject: General
Received: 2015/01/15 | Accepted: 2015/04/1 | Published: 2015/05/3


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Volume 18, Issue 2 (Iranian South Medical Journal 2015) Back to browse issues page