Volume 21, Issue 5 (Iranian South Medical Journal 2018)
Iran South Med J 2018, 21(5): 374-382 |
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Dehghani F, Kalantar Hormozi M, Nabipour I, Hajian N, Rahimi R, Ghasemi K. Effects of Short Term Resveratrol Supplementation on Thyroid Function in Pa-tients with Type 2 Diabetes. Iran South Med J 2018; 21 (5) :374-382
URL: http://ismj.bpums.ac.ir/article-1-957-en.html
URL: http://ismj.bpums.ac.ir/article-1-957-en.html
Fatemeh Dehghani1 
, Mohammadreza Kalantar Hormozi2 , Iraj Nabipour3 , Najmeh Hajian4 , Rahimeh Rahimi4 , Khadejeh Ghasemi5
, Mohammadreza Kalantar Hormozi2 , Iraj Nabipour3 , Najmeh Hajian4 , Rahimeh Rahimi4 , Khadejeh Ghasemi5
1- School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- Department of Internal Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
3- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5- Department of Children, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- Department of Internal Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
3- The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
4- Department of Biochemistry, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5- Department of Children, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
Abstract: (4454 Views)
Background: Resveratrol is one of the most effective natural polyphenolic compounds synthesized by plants and its beneficial effects on glycemic control have been reported. Considering the prevalence of thyroid disorders in diabetic patientsذثدثبهزهشم ثببثزفس خب فاهس یقعل.ompounds and the effect of resveratrol on metabolic pathway through Sirtuin1 receptors and its ability to change iodine absorption in thyroid gland, it is suspected that this compound might influence thyroid function and possible have goitrogenic effects.
Materials and Methods: This study enrolled 50 subjects with type II diabetes in an intervention and a control group. Patients received 500 mg resveratrol capsules twice a day for 45 days and subjects in the control group received equivalent placebo capsules. Thyroid function tests including T3, T4, TSH and T3RU and anti TPO were checked just before the study and after 45 days.
Results: Regarding past history and clinical and biochemical parameters including BMI, blood pressure and glycemic control, there was almost no significant difference between the two groups. Anti TPO levels did not significantly change between the two groups during the study. Finally changes between the two groups were compared using Mann-Whitney U test, which concluded significant changes only in T4 levels between the two groups during the course of the study.
Conclusion: We can conclude that taking resveratrol 1 gr a day for 45 days as a supplementary for lowering blood glucose in patients with type II diabetes does not cause goitrogenic effects. Further studies are suggested on resveratrol effects on thyroid function in humans with different doses and durations. Moreover, it is suggested that subjects with known thyroid disease with existing underlying pathology be studied to better understand its effects on thyroid function.
Materials and Methods: This study enrolled 50 subjects with type II diabetes in an intervention and a control group. Patients received 500 mg resveratrol capsules twice a day for 45 days and subjects in the control group received equivalent placebo capsules. Thyroid function tests including T3, T4, TSH and T3RU and anti TPO were checked just before the study and after 45 days.
Results: Regarding past history and clinical and biochemical parameters including BMI, blood pressure and glycemic control, there was almost no significant difference between the two groups. Anti TPO levels did not significantly change between the two groups during the study. Finally changes between the two groups were compared using Mann-Whitney U test, which concluded significant changes only in T4 levels between the two groups during the course of the study.
Conclusion: We can conclude that taking resveratrol 1 gr a day for 45 days as a supplementary for lowering blood glucose in patients with type II diabetes does not cause goitrogenic effects. Further studies are suggested on resveratrol effects on thyroid function in humans with different doses and durations. Moreover, it is suggested that subjects with known thyroid disease with existing underlying pathology be studied to better understand its effects on thyroid function.
Type of Study: Original |
Subject:
Endocrine System
Received: 2018/01/16 | Accepted: 2018/05/23 | Published: 2018/11/3
Received: 2018/01/16 | Accepted: 2018/05/23 | Published: 2018/11/3
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