%0 Journal Article %A Rahimikian, Raha %A Akbarzadeh, Samad %A Rahimi, Rahimeh %A Pourkhalili, Khalil %A Mahmoodi, Marzeah %A Seyedian, Ramin %A Ghasemi, Khadejeh %A Movahed, Ali %T Effects of Resveratrol on the Level of Urotensin II and its Receptors in the Homogenized Tissue of Diabetic Rats %J Iranian South Medical Journal %V 23 %N 3 %U http://ismj.bpums.ac.ir/article-1-1306-en.html %R 10.52547/ismj.23.3.236 %D 2020 %K Type 2 diabetes, heart disease, resveratrol, Urotensin 2, Urotensin 2 receptor, %X Background: Individuals with diabetes mellitus are at serious risk of a wide range of cardiovascular complications. Urotensin 2 and its receptors play an important role in the development of cardiovascular diseeases through production of reactive oxygen species (ROS). Resveratrol is a polyphenol with antioxidant and anti-diabetic properties. The present study aimed to investigate the effects of resveratrol on urotensin 2 and its receptors in the heart tissues of diabetic rats. Materials and Methods: In this experimental study, 48 male Wistar rats were divided into six groups (N= 8 in each group). Resveratrol was prepared in 0.5% carboxymethyl cellulose and given to the rats through oral gavage. At the end of the 60 days of treatment with resveratrol, rats’ heart tissue was collected. Results: The weight of diabetic rats treated with 10 and 90 mg/kg bw of resveratrol significantly increased compared with the diabetic group. Furthermore, the serum levels of FBS, lipids, MDA, CK-MB and LDH decreased in the treated diabetic rats compared with the control group. Moreover, concentration of urotensin 2 and its receptors significantly decreased in the heart tissues of the diabetic rats treated with resveratrol at the dose of 10 mg/kg bw compared with the control group. Conclusion: The current study indicated that resveratrol decreased FBS, lipids, weight, MDA and cardiac enzymes. Furthermore, resveratrol significantly reduced urotensin 2 and its receptors, which indicates its moderating effect on diabetes complications. %> http://ismj.bpums.ac.ir/article-1-1306-en.pdf %P 236-247 %& 236 %! %9 Original %L A-10-296-27 %+ The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran %G eng %@ 1735-4374 %[ 2020