TY - JOUR JF - ISMJ JO - Iran South Med J VL - 15 IS - 1 PY - 2012 Y1 - 2012/4/01 TI - Investigation on the anti- inflammatory and analgesic effects of Olea europaea L. metanolic extract on male NMRI mouse TT - بررسی اثرات ضددردی و ضدالتهابی عصاره متانولیک برگ درخت زیتون در موش‎های نر بالغ نژاد NMRI N2 - Background: Different mediators are involved in pain and edema induction during different stages of inflammation. Then, treatment of them encounters some difficulties. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory effects. This study was aimed to investigate anti-inflammatory and analgesic effects of Olea europaea L.methanolic extract on male NMRI mouse. Methods: Methanolic extraction was done for leaf of Olea europaea L. and different doses (200, 300 and 400 mg/kg) were intraperitoneally (i.p.) adminstered to male NMRI mice. Analgesic and anti-inflammatory effects of extract was measured during both phases of Formalin test, Acetic acid induced visceral pain and xylene inflammation tests. A standard analgesic and anti-inflammatory drug such as indomethacin, dexamethasone and morphine were administered in positive control groups where appropriates. Results: Results indicated significant dose-dependent analgesic and anti-inflammatory effects of methanolic extract of Olea europaea L. leaf on pain which induced by formalin (both phase) and acetic acid, and inflammation caused by xylene. Conclusion: Our findings Showed that administration of methanolic extract of Olea europaea L.leaf can suppress pain and inflammation dose dependently which, may mediate via different components of extract. However, more investigations need to be done. SP - 13 EP - 24 AU - Tekye, Elaheh AU - Moghadam nia, Sara AU - Eidi, Akram AU - Taghizadfarid, Reza AU - Ferdosi, Roohollah AU - Zarringhalam, Jalal AD - Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IRAN KW - Olea europaea L. KW - pain KW - inflammation KW - free radicals UR - http://ismj.bpums.ac.ir/article-1-309-en.html ER -