TY - JOUR JF - ISMJ JO - Iran South Med J VL - 16 IS - 6 PY - 2014 Y1 - 2014/1/01 TI - Evaluation of Rapid Urease Test Compared with Polymerase Chain Reaction for Diagnosis of Helicobacter pylori TT - ارزش تشخیصی آزمون اوره‌آز سریع در مقایسه با واکنش زنجیره‌ای پلی‌مراز جهت تشخیص عفونت هلیکوباکتر پیلوری N2 - Abstract Background: Current diagnostic methods for detecting Helicobacter pylori infection include rapid urease test (RUT), urea breath test (UBT), histology, culture, and polymerase chain reaction (PCR). RUT is the most commonly method to diagnose Helicobacter pylori infection because of its simple, rapid and accurate characters. The aim of this study is evaluation of rapid urease test compared with PCR for diagnosis of Helicobacter pylori. Material and Methods: In this study 94 patients with dyspeptic symptoms attending the endoscopy suite of gastroenterology section of the Firouzgar University Hospital, Tehran, Iran, were enrolled. Patient’s antrum biopsy specimens were collected at endoscopy for the rapid urease test and PCR. Data was recorded on a data sheet and analyzed using SPSS version 19.0. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of RUT was compared against PCR. The gold standard test for the diagnosis of Helicobacter pylori infection was PCR. Results: Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of RUT respectively were 97.2%, 89.2%, 81.4% and 98%. Conclusion: RUT has high sensitivity and specificity for detection of Helicobacter pylori infection. SP - 394 EP - 400 AU - Pakbaz, Zahra AU - Shirazi, Mohammad Hassan AU - Pourmand, Mohammad Reza AU - Azhdarkosh, Hossein AU - Vaise Malekshahi, Ziba AU - Afshar, Davood AU - . Hajikhani, Sara AU - Mardani, Nadia AD - Department of Pathobiology, School of Health, Tehran University of Medical Sciences, Tehran, IRAN KW - Helicobacter pylori KW - rapid urease test KW - PCR KW - biopsy UR - http://ismj.bpums.ac.ir/article-1-470-en.html ER -