RT - Journal Article T1 - Correlation between serum levels of uric acid with bone turnover markers in postmenopausal women JF - ISMJ YR - 2015 JO - ISMJ VO - 17 IS - 6 UR - http://ismj.bpums.ac.ir/article-1-625-en.html SP - 1090 EP - 1099 K1 - uric acid K1 - osteocalcin K1 - CrossLaps K1 - alkaline phosphatase K1 - menopause AB - Background: There is accumulation evidence regarding the protective role of higher serum uric acid in bone loss and osteoprotic fractures. This effect may arise from its antioxidant properties. The main aim of this study was to investigate serum uric acid in relation to bone turnover markers in postmenopausal women. Material and methods: A total of 382 postmenopausal women who participated in a prospective study were selected randomly from Bushehr port. Serum uric acid levels and biochemical markers including serum alkaline phosphatase were measured. Circulating levels of CrossLaps, osteocalcin and hsCRP were also measured by ELISA. Results: Uric acid levels had significant correlation with osteocalcin & alkaline phosphatase. However, no correlation could be found between uric acid and CrossLaps. The correlation between uric acid & osteocalcin (r= 0.25, P=0.0001) & alkaline phosphatase(r=0.12, P=0.019) remained after adjustment with age, BMI & hsCRP. Conclusion: Serum uric acid had a positive and significant correlation with osteoblastic born turnover markers. Hence, the role of uric acid in osteoblastic function should be investigated. LA eng UL http://ismj.bpums.ac.ir/article-1-625-en.html M3 ER -