@article{ author = {Bargahi, Afshar and RabbaniChadegani, Ozra and MohammadHasan, Zahir}, title = {Effect of shark cartilage on the cytotoxic activity of NK cells immune system}, abstract ={Background: On the basis of traditional medicine Shark cartilage have been used in the treatment of cancer especially immune related cancers. Then, we hypotheses that shark cartilage contains immune stimulatory ingredients. Methods: The immune stimulatory effect of shark cartilage derived proteins on the cytotoxic activity of natural killer cells(NK cells) from healthy human peripheral blood mononuclear cells (hPBMN) was studied. Shark cartilage proteins were purified by ion-exchange chromatography and ultra filtration. The effect of each protein fraction on the modulation of cytotoxicity of NK cells, as effectors, against K562, as target cells, was assayed by enzymatic LDH test. Results: The results from cytotoxic assay of NK cells and SDS- Polyacrylamide gell electrophoresis of shark cartilage protein fractions indicated that AR10 fraction, containing proteins with molecular weight of about 14.5 KDa is the most active ingredients of shark cartilage. Conclusion: Shark cartilage contains a 14.5 KDa protein that modulates NK cells activity of human immune system.}, Keywords = {cytotoxicity, NK cell, shark cartilage, purification, immunotherapy }, volume = {12}, Number = {3}, pages = {181-188}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-190-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-190-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2009} } @article{ author = {Izadi, Mojtaba and Eghdami, Anoosh and Khorshidi, Davood and Nazem, Farzad and Zarifian, Asghar}, title = {The investigation effect of heparin infusion on plasma glucose and Lactate during submaximal exercise}, abstract ={Background: Many investigations have demonstrated that increasing fat availability increases fat oxidation and decreases carbohydrate use in the whole body and skeletal muscle. The purpose of this study was to determine the effect of heparin infusion on some influential factors in aerobic metabolism and performance during submaximal cycling. Methods: Thirty healthy males (15 as control and 15 as target group) cycled for 20 min at 70% maximal O2 uptake (VO2max) in two separate stages (baseline and infusion of heparin or lactose. Blood samples were drawn immediately followed up exercise for calculating plasma glucose and lactate concentration and lactate dehydrogenase activity (LDH). VO2max also monitored. The finding are compared by T test (Independent-sample and Paired- samples T test) in two groups (P<0.05). Results: The finding showed that heparin infusion had not influence on plasma glucose, lactate concentration, and LDH activity (P<0.05). Also VO2max and heart rate had not significantly changed in posttest condition compare to pretest (P<0.05). Conclusion: Our findings suggested that heparin infusion is not affect aerobic capacity and carbohydrate substrate utilization during submaximal exercise. Additional investigation is required to directly identify these supplementations on the substrate utilization and fat-carbohydrate metabolism and exercise performance.}, Keywords = {heparin, free fatty acid, metabolism, aerobic exercise, lactate, glucose }, volume = {12}, Number = {3}, pages = {189-197}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-191-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-191-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2009} } @article{ author = {Tabatabaie, Seyed Abdolhossein and Asharin, Mohammad Reza and Assadi, Majid and Nabipour, Iraj and Ebrahimi, Abdol Ali and NasiriAhmadAbadi, Mojdeh and Moghadam, Mansour and Pourbehi, Mohammadrez}, title = {Comparsion of influence of enoxaparin with unfractioned heparin on acute myocardial infarction with ST-segment elevation}, abstract ={Background: Most patients with acute myocardial infarction with ST-segment elevation (STEMI) are still treated with pharmacological reperfusion which is not always successful. The aim of this study was to determine whether enoxaparin was associated with superior efficacy and safety compared with unfractionated heparin (UFH) in the STEMI setting. Methods: In this clinical trial, 150 patients less than 75 years old (104 men and 46 women) with STEMI who were scheduled to undergo streptokinase (1.5 milion unit per hour) randomly assigned to receive enoxaparin (40 mg intravenous bolus then 1 mg/kg subcutaneously BID) (group 1) or weight adjusted UFH from 24 to 48 hours after streptokinase (group 2). All patients underwent predischarge coronary angiography. Results: A number of 75 patients in group 1 (mean age 58.9 ±9.4) and 75 pateints in 2 (mean age 56.3±9.0) were studied. Two groups were well matched with respect to main risk factors and also other concomitant medications. Time from onset of symptom to start fibrinolysis and myocardial regions infarction were similar in both groups (p=0.13). Left ventricular ejection fraction were 45.2 ± 5.6 % in group 1 and 40.3 ± 7.3 % in group 2 (p=0.056). Major bleeding just was in 2 cases of group 1. Minor bleeding was in 10 cases of group 1 and 5 of group 2 (p>0.05). Conclusion: Our data showed a benefit of Enoxaparin compared with UFH in patients receiving fibrinolysis for STEMI with a mild trend toward an excess of bleeding. However, further well designed studies to assess these results with following patients for a longer period of time and also comparing therapeutic effects are needed.}, Keywords = {ST-segment elevation myocardial infarction, enoxaparin, unfractionated heparin, fibrinolysis}, volume = {12}, Number = {3}, pages = {198-205}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-192-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-192-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2009} } @article{ author = {Samilipour, Hooman and Azizi, Fatemeh and Motamed, Niloofar and Taiebi, Niloofar and DelavarKasmaie, Hossein and Karimi, Mojtab}, title = {Restless leg syndrome and its association with serum ferritin in dialysis patients in Bushehr province, 2006}, abstract ={Background: Restless leg syndrome (RLS) is a sensory-motor disorder that affects 6-83% of dialysis patients. Increased Urea and creatinine, and Iron deficiency anemia resulting from renal failure are some causes of restless leg syndrome. This study was aimed to evaluate this issue. Methods: A cross sectional study was done on 130 dialysis patients in 5 dialysis centers of Bushehr Province. The diagnosis of RLS was made using the criteria of the International Restless Leg syndrome. The length of renal failure, number of weekly dialysis, erythropoietin dose per week, dose of mineral Iron per day, other co morbidities and medications, ferritin level, and predialysis BUN were determined. Results: In this study 43 (33.1%) patients had restless leg syndrome who consisted of 18 (41.9%) women and 25 (58.1%) men. Positive family history was significantly associated with restless leg syndrome (p<0.016), and these patients had restless syndrome 3.39 times more than the others. Sex, age, ferritin level, length of renal failure, and BUN were not associated with restless leg syndrome. Conclusions: Restless legs syndrome is a common finding in dialysis patients in Bushehr Province. RLS was not associated with ferritin level in our study, but was significantly associated with family history of RLS.}, Keywords = {RLS, BUN, ferritin, uremia }, volume = {12}, Number = {3}, pages = {206-213}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-193-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-193-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2009} } @article{ author = {Fouladi, Zahra and Afshari, Pourandokht and Gharibi, Tayebeh and Dabbagh, Mohammad Ali}, title = {The comparison oF Zataria multiflora boiss (Avishan Shirazi) and Clotrimazol vaginal cream in the treatment of candidiasis vaginitis}, abstract ={Background : Vaginal candidacies is a second common infection in women. There are some evidences regarding efficiency of Zatoria Multiflora Boiss (Z.M.B) on dysmenorrea, leukorrea, and spasm. This study was conducted to assess the efficiency of Z.M.B in the treatment of candidacies vaginitisis. Methods: This double-blind trial was performed on the patients suffering from candidacies vaginitisis. Thirty-five patients received Z.M.Band 38 received Clotrimazole vaginal cream randomaly for 7 days. Data were analyzed using Chi-Square and Mc-Nemar tests. Results: There was significant improvement of signs and syndroms. in two groups (P0/05). Furthermore, 54/3% of patients taking Z.M.B and 47/4% of cases receiving Clotrimazole vaginal cream had complete improvement. Conclusion: The study demonstrated those Zataria multiflora Boiss could be a useful therapy for vaginal candidacies.}, Keywords = {vaginal candidacies, zataria multiflora Boiss, antifungal, clotrimazol}, volume = {12}, Number = {3}, pages = {214-224}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-194-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-194-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2009} } @article{ author = {Ebrahimi, Abdol Ali and Ebrahimi, Sekiineh and Aghouli, Mahmou}, title = {Survey of resistance rate of Shigella species isolated from children with diarrhea Fasa, Summer, 1383}, abstract ={Background: Shigellosis is an acute inflammatory infectious colitis which is caused by genus Shigella. The bacterial identification in large number of stool specimens and antimicrobial susceptibility test are useful for diagnosis and treatment. Methods: In this study the total number of 414 stool specimens of children under 8 years old were refered to various laboratory centers for determination of possible bacterial infection in Fasa city were. The diagnostic biochemical serological tests as well as antimicrobial susceptibility test were done. Results: Out of 414 stool specimens 48 (11.5%) cases were positive (S.flexneri, 50% S.sonnei, 31.% S.dysenteriae, 12.5% S.boydii, 6.%). Conclusion: This study emphasizes on the pediatric evaluation of resistancy of the antibiotics using in children.}, Keywords = {children, stool culture, Shigella, antimicrobial resistance test}, volume = {12}, Number = {3}, pages = {225-230}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-195-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-195-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2009} } @article{ author = {Nabipour, Iraj and Najafi, Arezoo and Bolkheir, Amir Rez}, title = {Anticancer and cytotoxic compounds from seashells of the Persian Gulf}, abstract ={Background: Pre-clinical studies for isolation and purification of marine compounds continued at an active pace since the last decade. Today, more than 60% of the anticancer drugs commercially available are of naturally origin thus the sea is a very favorable bed for the discovery of novel anticancer agents. Methods: A total of known 611 seashells species in the Persian Gulf were investigated for synonymy in OBIS database. Then, all the species, including their synonymy were searched in PubMed databse to find their isolated bioactive agents. Results: From 611 known seashells in the Persian Gulf, 172 genera/species had bioactive compounds. Anticancer agents were isolated and purified for 8 genera. These compounds had various structures they were polypeptide, polysaccharide, glycoprotein, alkaloid, cerebroside, and cembranoid which had different mechanism of actions including induction of apoptosis, destroying the skeletal structures of the cells, immune bioactivity and inhibition of topoisomerase I. Spisulosine is the only anticancer agent which is currently under clinical trial. Conclusions: Although, the known seashells from the Persian Gulf have potential anticancer and cytotoxic compounds but a very few investigations had been reported. Further investigations for isolation and purification on bioactive compounds from seashells of the Persian Gulf is recommended.}, Keywords = {seashell, anticancer, marine, cytotoxic, Persian Gulf}, volume = {12}, Number = {3}, pages = {231-237}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-196-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-196-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2009} } @article{ author = {Tabib, Seyed Masood and Nabipour, Iraj and MohseniAzad, Anali and Iranpour, Darioush and Farzaneh, Mohammadrez}, title = {A case of apathetic hyperthyroidism with exudative low SAAG ascites}, abstract ={The development of ascites in hyperthyroid patients is a rare phenomenon and usually occurs in the context of exaggeration of right-sided heart failure , so it is categorized as high SAAG ascites. In this case report, we present a 73-year-old man who was referred to us with anorexia, severe weight loss, anemia, lower limbs pitting edema, and also exudative, low SAAG ascites. Extensive work up revealed that these constellation of signs & symptoms were consequent to decompensation of his chronic right-sided heart failure resulting from apathetic hyperthyroidism.}, Keywords = {low SAAG ascites, exudative ascites, apathetic hyperthyroidism, right-sided heart failure }, volume = {12}, Number = {3}, pages = {238-243}, publisher = {Bushehr University of Medical Sciences}, url = {http://ismj.bpums.ac.ir/article-1-197-en.html}, eprint = {http://ismj.bpums.ac.ir/article-1-197-en.pdf}, journal = {Iranian South Medical Journal}, issn = {1735-4374}, eissn = {1735-6954}, year = {2009} }