Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Comparison of Cytotoxicity and anti-cancer activity, by Artemia urmiana Brine Shrimp Lethality Test(BSLT) and Cancer Cell leukemia and Breast Cancer by two species of Daphne
922
929
FA
Maneje
Mianabadi
Department of Biology, Faculty of Science, Golestan University, Gorgan, Iran
N
Esmaeal
Panahi Kokhdan
Department of Biology, Faculty of Science, Golestan University, Gorgan, Iran
esmaeel_panahi@yahoo.com
Y
Azizolah
Jafari Kokhdan
Department of biology, Faculty of Science, Yasuj University, yasuj, Iran
N
Hebatollah
Sadeghi Mansourkhani
Cellular and Molecular Research Center, Yasuj University of Medical Science, Yasuj, Iran
N
10.7508/ismj.1394.05.001
Background: Nowadays, toxic compounds derived from plants used against microbes and cancer cells. The aim of this study was to evaluate cytotoxicity and anticancer activity of two species of Daphne, Betulin and Betulinic acid by Artemia urmiana Brine Shrimp Lethality Test (BSLT) and trypan blue exclusion method.
Material and Methods: This study was conducted as the experimental design. 106 cells of K562, MCF-7 cancerous cell line in triplicate were poured into the cultured dishes containing medium and incubated for 24 hour. Cells were treated with various concentration of the plant extract and plant compound for for 24 hour. Cell viability was assessed using trypan blue dye exclusion method. Cytotoxicity evaluation was performed using larvae hatched cysts were purchased from Artemia Research Center, Urmia University. Live shrimp larvae were treated with different concentrations of extract and the numbers of live and dead larvae were counted after 24 hours. lethal concentration %50 (LC50) of any extracts on live larvae based on the data w Was obtained. The data were analyzed using the Varience and Probit analysis.
Results: inhibition proliferation 50% of Betulin, and Betulinic acid in treated cells line K562
(5.8±1.2 1nM, 12.2±0.67 nM, respectively) and MCF-7 (18.04±1.11 nM, 21.47±0.37 nM) were measured. Hydro ethanol extracts of Daphne mucronata and Daphne oleoides exhibited potent brine shrimp lethality with lethal dose 50 % of them was 2.01±0.16 mgDW/ml, 2.37±0.88mgDW/ml respectively. In both tests, the effect of plant material was directly related to their concentration.
Conclusion: According to the results, Daphne mucronata and Betulin were the most effective herbal substance. Thus, we can conclude that Daphne mucronata contains anticancer and toxic compounds.
Cytotoxicity, Betulin, Betulinic acid, Daphne oleoides, Daphne mucronata
http://ismj.bpums.ac.ir/article-1-727-en.html
http://ismj.bpums.ac.ir/article-1-727-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Relationship of bronchodilator response with oxygen pulse and ventilatory threshold in children with asthma: the effect of body composition and progressive aerobic activity in an environment with low humidity
930
943
FA
Samera
Puyan majd
Department of physiology, Faculty of physical education , mazandaran University , mazandaran, Iran
N
Atefah
Hashemi
Department of physiology, Faculty of physical education , mazandaran University , mazandaran, Iran
N
Valiollah
Dabidi Roshan
Department of physiology, Faculty of physical education , mazandaran University , mazandaran, Iran
vdabidiroshan@yahoo.com
Y
10.7508/ismj.1394.05.002
Background: Asthma is a leading cause of chronic illness in children, impacting heavily on their daily complications. The purpose of the present study was to relationship bronchodilator response (BDR) with oxygen pulse (OP) and ventilatory threshold (VT) in asthma children with various body compositions during progressive aerobic activities.
Material and Methods: 25 obese children (BMI>25 and %fat>30)with asthma(10 subjects), and healthy children (15 subjects) and 25 lean children(BMI<20 and %fat<20) with asthma(13 subjects), and healthy children (7 subjects) performed an exercise protocol in a constant temperature environment 2 ± 22 ° C and humidity (5 ± 35%). During exercise, the steady-state levels of cardio-respiratory parameters were measured using gas analyzer (K4B2).
Results: The results showed that after a progressive aerobic activity, values peak oxygen consumption(vo2peak) , bronchodilator(BDR), oxygen pulse(OP) and ventilatory threshold(VT) in lean and obese asthmatic children were lower than in healthy lean and obese children. In addition, lean children with asthma had lower VT and higher VO2peak , OP and BDR values, as compared obese asthmatic children. Between BDR and VT in lean and obese asthmatic children an inverse relationship between BDR and OP and a direct link to asthma in obese children and obese asthmatic children, there was a negative relationship non-significant.
Conclusion: Compared with lean children, asthma, obesity as an additional load will affect lung function and increase the pressure on childhood asthma. Therefore, we can accept that obesity may limit performance of exercise in childhood asthma.
Cardiovascular, asthma, body composition, childhood
http://ismj.bpums.ac.ir/article-1-728-en.html
http://ismj.bpums.ac.ir/article-1-728-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Removal of Cr (VI) from aqueous solutions by nano-sized magnetite modified with SDS
944
959
FA
Ali Akbar
Babaei
Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran<br> Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
N
Zeinab
Baboli
Department of Environmental Health Engineering, Behbahan facult of Medical sciences, Behbahan, Iran.
baboliz87@gmail.com
Y
Mehdi
Ahmadi
Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran<br> Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
N
Nematollah
Jaafarzadeh
Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran<br> Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
N
Gholamreza
Goudarzi
Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran<br> Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
N
Azar
Mostufi
Department of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
N
10.7508/ismj.1394.05.003
Background: Contamination of aquatic bodies with heavy metals is a serious environmental problem. Chromium is a common contaminant in ground and surface water, soil and wastewater. The aim of this study was to use magnetite nanoparticles modified by sodium dodecyl sulphate (SDS) for removal of hexavalent chromium from aqueous solutions and various factors affecting the uptake behavior such as pH, contact time, initial concentration of metal ions, adsorbent concentration, were studied.
Materials & Methods: SDS modified magnetite nanoparticles were prepared by co-precipitation, and characterized by X-ray diffraction, SEM scaning electron microscopy. The XRD diffractogram showed purity of the magnetite nanoparticles and the SEM image showed that the modified magnetite particles were 50 nm.
Results: The results showed that highest adsorption (99.7%) for Cr(VI) was occurred at pH=4, adsorbent dosage 2 g/L, initial concentration Cr(VI) 10 mg/L and contact time 60 min. The adsorption data was correlated to different non-linear isotherm and kinetic models and the data fitted better to the Freundlich isotherm model. The kinetics of the Cr(VI) adsorption followed Ho (Pseudo-second-order) model.
Conclusion: The SDS modified magnetite nanoparticles appears to be very effective at removing the Cr(VI) from aqueous solution.
SDS modified magnetite nanoparticles, Cr(VI), Adsorption, Isotherm, kinetic
http://ismj.bpums.ac.ir/article-1-729-en.html
http://ismj.bpums.ac.ir/article-1-729-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
The Estimation of Radon Gas Annual Absorbed Dose in Rafsanjan and Anar Residents Based on Measurement of Radon Concentration Dissolved in Water
960
969
FA
Ahmad
Asadi Mohammad Abadi
Department of Physics, Faculty of Science, Payam Noor University, Tehran, Iran
asady_esf@yahoo.com
Y
Mojtaba
Rahimi
Department of Physics, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
N
Lila
Jabbari koopaei
Department of Statistics,Faculty of Mathematical Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
N
10.7508/ismj.1394.05.004
Background: The most important natural radioactive resource to which people are exposed is Radon gas. Radon gas produced deep in the earth enters into underground waters and dissolves in them. The Radon gas in water supplied for home uses enters the body by either drinking water or inhaling Radon gas released into the air and causes stomach and lung cancers. The purpose of this study is determination of annual effective absorbed dose of Radon gas in Rafsanjan and Anar residents.
Material and Methods: This study is experimental and is done on 36 randomly selected resources of drinking and agricultural water in Rafsanjan. Measuring the concentration of Radon gas dissolved in water by the electronic detector RAD7 and statistical analysis of data, the annual absorbed dose of Radon gas by adults and children continually using water of these sources is estimated.
Results: The minimum and maximum amount of Radon gas concentration in drinking water are 0.32±0.12 Bq/lit and 13.90±2.45 Bq/lit while the minimum and maximum amount of Radon gas in agricultural resources of water are 3.68±1.25 Bq/lit and 24.51±3.87 Bq/lit, respectively. Therefore, the annual absorbed dose of Radon gas by adults and children using drinking water is between 3.16±1.17 µSv/year and 136.22±24.01 µSv/year and 4.33±1.61 µSv/year and 186.95±32.95 µSv/year, also it is between 36.06±12.25µSv/year and 240.20±37.93µSv/year and 49.49±16.81µSv/year and 329.66±52.05 µSv/year for those using agricultural water
Conclusion: it has been concluded that the amount of Radon gas dissolved in the water of this region is approximately high however, different methods of releasing the existing Radon gas of drinking water along with informing people about the dangers of this gas can decrease the natural exposure caused by Radon gas.
Radon Gas, Absorbed dose, Water sources, Rafsanjan, Anar, RAD7 detector
http://ismj.bpums.ac.ir/article-1-730-en.html
http://ismj.bpums.ac.ir/article-1-730-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Emergence of Multi-drug Resistant ESBL Producing Strains among Enterobacteriaceae Members Isolated from Patients Blood Samples in South of Iran
970
981
FA
Jalal
Mardaneh
Department of Microbiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
N
Mojtaba
Anvarinejad
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
N
Amin
Abbasian
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
N
Pejman
Abbasi
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
N
Nourodin
Rafaatpour
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
N
Mohammadali
Dehyadegari
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
N
Bahman
Pourabbas
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
N
Gholamreza
Pouladfar
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
N
Maneli
Amin Shahidi
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
maneli1969@yahoo.com
Y
10.7508/ismj.1394.05.005
Background: Extended-spectrum beta-lactamases (ESBLs) have emerged as important mechanism of resistance among enterobacteriaceae family. These ESBL positive strains are major problem in hospitalized patients. The goal of this study was the survey emergence of multi-drug resistant ESBL producing strains among enterobacteriaceae members isolated from patients blood samples using BACTEC 9240 automatic system in south of Iran.
Materials & Methods: In this cross-sectional study, 4825 blood samples were collected from hospitalized patients, and positive samples were detected by BACTEC automatic system. Positive blood cultures removed from BACTEC and subculture was performed on microbiological media including blood agar, chocolate agar and MacConkey agar. The isolates were identified based on biochemical tests embedded in the API-20E system. Susceptibility testing (disc diffusion) was performed according clinical and laboratory standards institute (CLSI, 2013) guidelines. Phenotypic detection of extended spectrum beta-lactamase producing isolates was performed by double disk synergy test (DDST).
Results: Total 1145 (24%) blood cultures were positive that among them 248 (21.5%) belonged to the enterobacteriaceae family. The most common isolates in this family were Escherichia coli (46.5%), Klebsiella spp. (28%), Enterobacter spp. (13.5%). Among enterobacteriaceae family, ampicillin was most effective drug against Salmonella isolates. Escherichia coli was the most common ESBL-producing isolate (58% of isolates were ESBL positive). Respectively, polymyxin B, colistin, imipenem were the most effective drugs against ESBL-positive Klebsiella strains. The ESBL-positive Enterobacter strains showed lowest resistance to imipenem (7.7%). All ESBL positive Serratia isolates were sensitive to chloramphenicol, co-trimoxazole and imipenem.
Conclusion: Results showed unfortunately betalactam antibiotics are not effective against more than 40% of bacteremia caused by Escherichia coli and Klebsiella and 39% bacteremia caused by Enterobacter. Multi drug resistance strains are increasing and treatment of infections causing by this isolates are major problem in Iran.
Bacteremia, Blood culture, BACTEC 9240 system, Enterobacteriaceae, Antibiotic resistance, ESBL.
http://ismj.bpums.ac.ir/article-1-731-en.html
http://ismj.bpums.ac.ir/article-1-731-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Effect of intermittent feeding on metabolic symptoms of chronic stress in female NMRI mice
982
991
FA
Zahra
Ghanbari
Department of Biology, Islamic Azad University, North Tehran branch, Tehran, Iran
N
Maryam
Khosravi
Department of Biology, Islamic Azad University, North Tehran branch, Tehran, Iran
N
Fatemesadat
Hoseini Namvar
Department of Biology, Islamic Azad University, North Tehran branch, Tehran, Iran
N
Badri
Zarrin Ehteram
Department of Biology, Islamic Azad University, North Tehran branch, Tehran, Iran
N
Nahid
Sarahian
Department of Biology, Islamic Azad University, North Tehran branch, Tehran, Iran
N
Hedayat
Sahraei
Neuroscience Research Center, Baqiyatallah [a.j.] University of Medical Sciences, Tehran, Iran
h.sahraei@bmsu.ac.ir
Y
10.7508/ismj.1394.05.006
Background: Calorie input reduction (CIR) can improve central nervous system functions. However, there is no study dealing with the effect of CIR on the hypothalamic-pituitary-adrenal (HPA) axis activity as the main neuro-endocrine system in this regard. In the present study, the effect of CIR (intermittent feeding) on metabolic responses to stress was examined.
Material and Methods: Female mice with an average weight of 27 ± 3 g were divided into 4 groups of 7. The control group received adequate food and water without stress. The second group was deprived from food (2 hours/day for seven consecutive days) and then electro foot-shock stress was applied to them for 4 days. The third group was deprived from food 2 hours/day for a week, and the fourth group received 4 days of electric shock without food deprivation. Blood samples were collected from all animals for plasma corticosterone evaluation.
Results: Stress and intermittent food increased plasma corticosterone levels while intermittent feeding when combined with stress, no increment was observed in plasma corticosterone level. Stress decreased food intake, but the intermittent feeding with or without stress increased food intake. Stress and intermittent feeding decrease delay to eating time whereas this was opposite in the group in which received both stress and intermittent feeding. Stress and intermittent feeding did not affect the animal's weight gain. In addition, fecal material was decrease in groups experience stress, intermittent feeding and stress in combination with intermittent feeding.
Conclusion: Intermittent feeding inhibits stress-induced metabolic responses. This inhibition in plasma corticosterone level, feeding and weight gain were observed.
nutrition, intermittent, chronic stress, corticosterone, mice
http://ismj.bpums.ac.ir/article-1-732-en.html
http://ismj.bpums.ac.ir/article-1-732-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Fat characteristics and fatty acid profile of sea cucumbers (Holothuria Scabra) obtained from the coasts of the Bushehr province -Iran
992
1006
FA
Najmeh
Jadavi
Department of chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
N
Seydali
Vaziri
Department of chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
N
Iraj
Nabipour
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
N
Mohammadreza
Jafari Nasr
Department of chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
N
Gholamhosean
Mohebbi
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
mohebbihsn@yahoo.com
Y
10.7508/ismj.1394.05.007
Background: Sea cucumbers are belonging to echinoderms and one of the important members of the food chain in temperate ecosystems and tropical coral reefs. The medicinal and nutritional uses of these invertebrates are primordial and are important as ecological, biological and economic properties. Holothuria Scabra, as one of the most valuable commercial species of sea cucumber in the world, is the dominant species in many Persian Gulf coasts such as the Bushehr province coasts. Conspicuous characteristics such as the use of inexpensive foods in their culture, the rather rapid, easy and low cost growth and reproduction, the possibility of culture with other fish, reduce the organic substrate in pools, the broad tolerance in water factors changes such as salinity and temperature it has selected them to culture.It seems they are containing the significant amounts of nutrients, especially appreciated fatty acids. Therefore, the aims of the current study are determination of total fat content, quality and quantity evaluations of some physicochemical parameters such as acid value (AV), peroxide value (PV), and refractive index (RI) as well as, identify the profile of fatty acids in the fat.
Materials & Methods: In this study, after collecting the 36 samples of sea cucumbers from the coasts of the bushehr province, sample preparation, and extraction of fat, their fatty acids profile were analyzed using gas chromatography with flame ionization detector (GC-FID).
Results: The peroxide and the acid values were 0.62±0.0435 and 0.7553±0.0034. The optical refractive index of the oil was 1467 at 26°C, and total fat was also 2%. Among 19 identified fatty acids obtained from the GC analysis of Holothuria Scabra oil, fatty acids: heneicosanoic acid, linoleic acid, palimitic acid, stearic acid, linoleic acid, and Meristic acid, with respectively amounts of 40.81%, 27.5%, 15.24%, 4.73%, 4.46% and 2.38% had the highest values, and other fatty acids were negligible.
In a current study, the total amount of saturated and unsaturated fatty acids, were respectively 59.194% and 40.806%.
Conclusion: Evaluation of H. Scabra oil revealed that the sea cucumber is a rich source of fatty acids, particularly unusual and rare fatty acids, such as heneicosanoic acid with different uses in pharmaceutical, medical, cosmetic, and industrial areas. In accordance with the valuable biological effects of heneicosanoic acid such as inhibition of p53 it is recommended some studies such as their anticancer effects also, because of the adequate geographical conditions at Bushehr, it is proposed the culture of these advantageous animals.
Sea cucumber, Fatty acids profile, Acid value (AV), Peroxide value (PV), Refractive index (RI), Gas chromatography, Heneicosanoic acid
http://ismj.bpums.ac.ir/article-1-733-en.html
http://ismj.bpums.ac.ir/article-1-733-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Cultivation and Comparison Drug and Nutritional Value of Milk Thistle Ecotypes
1007
1015
FA
Mohammadamin
Kohanmoo
Plant Breeding Department, College of Agricultural and Natural Resources, Persian Gulf University, Bushehr, Iran
kohanmoo@pgu.ac.ir
Y
Mohammad
Modarresi
Plant Breeding Department, College of Agricultural and Natural Resources, Persian Gulf University, Bushehr, Iran
N
Zeinab
Bagheri Kahkesh
Plant Breeding Department, College of Agricultural and Natural Resources, Persian Gulf University, Bushehr, Iran
N
10.7508/ismj.1394.05.008
Background: Milk thistle ecotypes have drug and nutritional value. Ecological and agronomical needs should be recognized and were selected for cultivation. The aim of this study was comparison of Milk thistle ecotypes for feeding and pharmacy value in order to selection and cultivation in Bushehr province.
Materials and Methods: Field study was carried out in a randomized complete design with three ecotype (in four replication) in growing season of 2012-13 at the research farm of Persian Gulf University (Borazjan campus). Morphological and phytochemical traits were measured. Oil content and methanol extract were prepared by Soxhelt extraction and maceration method respectively Fatty acid profile and total Sylimarin were analyzed by GC and rotary evaporator devices. Data was analyzed by ANOVA and DMRT test methods.
Results: Morphological and yield related traits, fatty acids and total Sylimarin had statistically significant different, but oil content was not significant (P&le 0.01). Highest seed yields, total sylimarin (6.5 %) and oil content (25.5 %), were related to Ecotype no. 2, selected population and ecotype no. 1 and 2 ecotypes respectively. Saturated fatty acid: Unsaturated Fatty acid ratio in selected population and ecotypes were measured 3.32 % and 3.99 % respectively.
Conclusion: Results showed significant differences between Morphological and phytochemical traits in three ecotypes. Maximum yield (1417 kg ha-1), oil percentage (354 kg ha-1) and lowest total sylimarin were related to Ecotype no. 2. These ecotypes can be selected and cultivated for commercial propose in Bushehr province.
Milk thistle, Ecotype, Fatty acid, Sylimarin
http://ismj.bpums.ac.ir/article-1-734-en.html
http://ismj.bpums.ac.ir/article-1-734-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Assessment of MDRTB in bushehr province since 2009-2013
1016
1025
FA
Mohammadjavad
Haerinejad
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
N
Naghmeh
Honarmand
Department of Communicable Diseases, Provincial Health Center, Bushehr University of Medical Sciences, Bushehr, Iran
N
Saead
Tajbakhsh
Department of Microbiology and Parasitology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
N
Marzeah
Shahin
Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
N
Omid
Gharibi
Central Laboratory for tuberculosis, health center
N
Katayon
Vahdat
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
vahdatpg@bpums.ac.ir, vahdatk@gmail.com
Y
10.7508/ismj.1394.05.009
Background: MDRTB has been identified as a developing threat , in recent years. MDRTB treatment costs 100times more than sensitive TB and requires intensive long time management and it has more health complications.
Materials & Methods: sputum samples were collected from all new cases of TB that faced with treatment failure in bushehr province between 2009 and 2013, and sent to Dr.Masih Daneshvari hospital for drug susceptibility test. In this study RFLP method was used for DNA isolation and PCR multiplex was used to assess drug sensitivity.
Results: we found 398 new cases of TB in three years of study, and 39 patients faced with treatment failure, finally six of them were reported as MDRTB (1.5%).
Conclusion: our data are close to the national statistics, however it is necessary to prevent further spread of resistant TB.
Tuberculosis, Drug resistant, PCR multiplex
http://ismj.bpums.ac.ir/article-1-735-en.html
http://ismj.bpums.ac.ir/article-1-735-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Prevalence of skin lesions in diabetic patients, Arak:1392
1026
1033
FA
Mina
Mirnezami
Department of Dermatology, Faculty of Medicine, University of Medical Sciences Arak, Iran
N
Afsaneh
Talaei
Thyroid Disorders Research Center, Department of Internal Medicine, Faculty of Medicine, University of Medical Sciences Arak, Iran
afsanehtalaeii@yahoo.com
Y
10.7508/ismj.1394.05.010
Background: Diabetes mellitus (DM) is the most common of the endocrine disorders characterized by hyperglycemia. Diabetes mellitus affects every organ of the body including the skin. Skin lesions have negative impact on quality of life of diabetic patients and it is also very frustrating for both patients and their physicians. The pathophysiologic mechanisms of skin lesions are mainly unknown.The aim of this study was to evaluate the frequency of skin manifestations in this patients.
Materials & Methods: A cross sectional study was performed on 700 patients attending to the diabetes clinic. The Institute ethical clearance was obtained before the start of the study.A complete cutaneous examination was done in all cases. A detailed dermatological examination was carried out by a consultant dermatologist and cutaneous findings were recorded. Relevant microbiologic and histopathological investigations were done whenever they were necessary to diagnose the cutaneous disorders.Statistical analysis was carried out by using t- test and Chi-square test.
Results:Seven hundred patients(73% women and 27% men )were enrolled in the study.Diabetic skin manifestations were detected in 94.5% of diabetic patients.The most common skin lesions were cherry angioma (37%),skin tag (32%) and eczema (32.8%).Our study showed a significant difference between the involvement by skin lesions and duration of diabetes (P=0.05) and age of patients (P=0.03) but it didn,t show any significant difference between the involvement of skin lesions and HbA1C
Conclusion: Our study showed that the skin lesions are common in DM patients and the duration of diabetes and age are positively correlated with skin lesions. For these reasons, education and special attention to medical staff and patients and searching approach to early diagnosis and treatment of skin lesions seem to be necessary.
Diabetes, duration of diabetes, skin lesions, eczema, skin tag
http://ismj.bpums.ac.ir/article-1-736-en.html
http://ismj.bpums.ac.ir/article-1-736-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Survey on prevalence and causes of self-medication in women referring to health centers in Ahwaz, in 2013
1034
1044
FA
Pourandoght
Afshary
Department of Midwifery, Faculty of Nursing, University of Medical Sciences, Ahvaz, Iran
N
Solmaz
Mohammadi
Department of Midwifery, Faculty of Nursing, University of Medical Sciences, Ahvaz, Iran
sl.mohammadi89 @yahoo.com
Y
Shosi
Koshteh
Department of Midwifery, Faculty of Nursing, University of Medical Sciences, Ahvaz, Iran
N
Seyedeh Zahra
Pajohideh
Department of Midwifery, Faculty of Nursing, University of Medical Sciences, Ahvaz, Iran
N
Hamed
Tabesh
Department of Epidemiology and Biostatistics, School of Public Health, University of Medical Sciences, Ahvaz, Iran
N
10.7508/ismj.1394.05.011
Background: Today, considerable advances achieved in different scientific fields have led to an ever-increasing access of people to various medications and their unauthorized consumption, which negatively affects the healthcare and treatment system. Thus, this study was conducted to determine the Prevalence and causes of this phenomenon in the female population of Ahwaz.
Material and Methods: In this Cross-sectional study364 Women referring to seven health centers in Ahwaz were selected randomly and based on the family medical file number and by proportional distribution to each center and semi-structured questionnaires were completed through interviews. The data were analyzed by Chi square test and logistic regression. P<0.05 was considered significant.
Results: Self-medication was observed in 70.1% of women. The most frequent group was those above the age of 30. The most common self-medication case was urogenitaldisorders (58.7%). there was a significant relation between education (p<0.003) and number of births (p=0.003) and unauthorized drug consumption. The most causes for synthetic drug use were previous illness background (48.6%) and high medication costs (50.6%), and about herbal drugs were high medication costs (41.1%), and the effectiveness of these products about medicinal herbs (38.1 %).
Conclusion: High rate of self-medication in the studied society necessitates training on proper use of drugs through the use of social media.
self-medication, Synthetic Drugs, Herbal Drugs, Medicinal Herbs, women
http://ismj.bpums.ac.ir/article-1-737-en.html
http://ismj.bpums.ac.ir/article-1-737-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
A rationale for a museum of health
1090
1102
FA
Farzaneh
Yousefi
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
N
Iraj
Nabipour
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
N
Alireza
Raeisi
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
N
Majid
Assadi
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
assadipoya@yahoo.com
Y
10.7508/ismj.1394.05.012
The museum of health is a place that presents health science and human body and any other subjects that can affect human health. In this museum visitors can learn the mechanisms and functions of human body and learn how to protect and take care of their bodies. They can also learn several diseases and their consequences on human body and how to fight against them. This museum is a big step for improvement of general society health level by increasing society’s health knowledge. In this article structure, departments and also benefits of the health museum are evaluated.
museum of science, health, well being
http://ismj.bpums.ac.ir/article-1-741-en.html
http://ismj.bpums.ac.ir/article-1-741-en.pdf
Bushehr University of Medical Sciences
Iranian South Medical Journal
1735-4374
1735-6954
18
5
2015
11
1
Biological activities of secondary metabolites of the order Zoanthids
1103
1114
FA
Zahra
Aminikhoei
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
zamini.41@gmail.com
Y
Zeinab
Janahmadi
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
N
Iraj
Nabipour
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
N
10.7508/ismj.1394.05.013
The phylum Cnidaria is a large, diverse and ecologically important group of marine invertebrates, which produce powerful toxins and venoms. The number of marine natural product from cnidarians isolated from class Anthozoa. Among the Anthozoa, the order of zoanthids are sessile, clonal and mostly brightly colored invertebrate which produce high biodiversity of cytolitic, neurotoxic and cardiotoxic compounds. Zoanthids containing palytoxins are reportedly among the most toxic marine organisms known. In addition, a high concentration of zoanthamine alkaloids extracted from this group.The zoanthamine alkaloids were isolated over 20 years ago, exhibit a broad range of biological activities.The best studied and most well-known biological activity of zoanthamine derivative significantly suppressed bone resorption and enhanced bone formation.
Class Anthozoa, Order zoanthids, Marine natural product.
http://ismj.bpums.ac.ir/article-1-742-en.html
http://ismj.bpums.ac.ir/article-1-742-en.pdf