2024-03-29T06:08:05+03:30 http://ismj.bpums.ac.ir/browse.php?mag_id=56&slc_lang=fa&sid=1
56-884 2024-03-29 10.1002
Iranian South Medical Journal Iran South Med J 1735-4374 1735-6954 10.52547/ismj 2017 20 4 The Study of the Effect of Levothyroxine on Dysfunctional Uterine Bleeding (DUB) in Euthyroid Women Mehri Jamilian Afsaneh Talaei afsanehtalaeii@yahoo.com Ali Chehrei Mohammad Reza Rezvanfar Fatemeh Rafei Background: Hypothyroidism and hyperthyroidism are recognized as two principal causes of DUB (dysfunctional uterine bleeding) which is characterized by the menstrual cycle irregularities. Since the thyroid hormones can alter the menstrual periods; levothyroxine intake may affect the DUB in euthyroid women. Material and Methods: This study was conducted as a randomized, double-blind, placebo-controlled clinical trial. The participants included 120 females aged between 35to 55 years old suffering DUB with non-organic origin. All of these patients had normal thyroid function, and they were taking an oral contraceptive pill (OCP). The participants were divided into two groups of 60 women. The intervention group received one tablet of levothyroxine 0.1 mg daily, while the control group received placebo for three months. At the end of three months, the data were analyzed using SPSS software version 16, and the comparison between two groups was measured using paired Student’s t-test, and covariance analysis. Results: Our study showed that improvement rate based on the overall mix of indicators used for evaluation of menstrual cycle irregularities was 48(80%) and 51(85%) in intervention and control groups respectively. Comparision between the intervention and control groups showed no significant difference in the overall indicators of improvement before and after the intervention in these two groups (P=0.47). However, the comparison of recovery rate based on different signs of irregularities in menstrual cycles in two groups showed that recovery rate based on metrorrhagia was significantly higher in the intervention group (100%) compared to control group. Also, covariance analysis showed that the intervention group had a significantly higher recovery rate based on the duration and the interval of bleedings, and the number of pads used during menstruation, compared to control group the (F=4.352, P=0.006). Conclusion: Levothyroxine intake can improve the menstrual cycle irregularities in euthyroid women.   Levothyroxine DUB euthyroid Women 2017 8 01 317 325 http://ismj.bpums.ac.ir/article-1-884-en.pdf
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Iranian South Medical Journal Iran South Med J 1735-4374 1735-6954 10.52547/ismj 2017 20 4 on The Study of Herbal Combination Effect of Securigera Securidaca, Vaccinium Arctostaphylos, Citrullus Colocynthis and Coriandrium Sativum on Triglyceride of Pre-Diabetic Elderlies Zinab Shababi Shahnaz Pouladi Sh.pooladi@bpums.ac.ir Ali Reza Raeisi Nilofar Motamed Mohammad Reza Farzaneh Background: Increasing blood sugar and hyperlipidemia in could deteriorate the late complications in diabetic patients. Hence, this study aimed to evaluate the herbal combination effects of Securigera securidaca, Vaccinium Arctostaphylos, Citrullus Colocynthis and Coriandrum sativum on triglyceride level in pre-diabetic elderlies. Materials and Methods: In a single-blind randomized controlled trial study, 60 pre-diabetic individuals aged between 60 to 70 years with a triglyceride level of 180-250 mg/dl were selected. They were divided into two groups (drug and placebo) randomly. The drug group received a diet including 500 mg capsules of herbal blend once daily, and the placebo group received diet including placebo capsules (500 mg flour) in the same period. The serum triglyceride level was evaluated after 30 days in both groups. Finally, the SPSS software version 18 was used for data analysis. Results: The mean triglyceride level, between before the intervention and afterward were not significantly different, and the mean changes in triglyceride level in total showed no significant differences as well. Likewise, the comparison between the mean triglyceride level before and after the intervention, independently Translation errorin drug group or placebo revealed no statically significant differences. Conclusion: There is no adequate evidence for the efficiency of this 30-day period intervention of herbal blend. Therefore it is recommended to perform further studies using different drug dosage and period of consumption to get more conclusive results about the potential effectiveness of these herbal medications on elderly’s triglyceride level.   elderly pre-diabetes hyperlipidemia securigera securidaca vaccinium arctostaphylos citrullus colocynthis coriandrium sativum 2017 8 01 326 338 http://ismj.bpums.ac.ir/article-1-885-en.pdf
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Iranian South Medical Journal Iran South Med J 1735-4374 1735-6954 10.52547/ismj 2017 20 4 Better Diagnosis of Acute Appendicitis by Using Artificial Intelligence Mir Mekaeal Hosseini triplex.mmm@gmail.com Reza Safdari Lila Shahmoradi Mojtaba Javaherzadeh Background: Acute appendicitis is the most common cause for the referral of patients with abdominal pains to the emergency department of hospitals and appendectomy is the most common medical emergency operation. Despite the introduction of the various diagnostic methods, exorbitant appendectomy rate still is significant. Therefore, artificial intelligence and machine learning methods could be used as an adjunct tool to improve the diagnosis and treatment of acute appendicitis. Particularly, it can facilitate earlier and more accurate diagnosis, reduce the length of stay in the hospital and decrease the treatment costs. Materials and Methods: During this developmental research, literature, and resources related to gastrointestinal diseases were studied, variables contributing to the diagnosis were evaluated and categorized by surgeons. The data collected from 181 cases of patients who underwent appendectomy at the Modarres Hospital during 2015 were used as the research database. Then, the support vector machine systems with different architectures implemented and compared to determine the best diagnostic function. Sensitivity, accuracy, and specificity outcomes were used for verification, evaluation, and defining the optimal diagnostic function. Results: The output obtained from the system of vector machine indicated 91.7, 96.2, and 95 percent for sensitivity, specificity, and accuracy of respectively, which expresses its sufficient efficiency in detecting acute appendicitis. Conclusion: The results showed that designed support vector machine could be used for the diagnosis of acute appendicitis, resulting in timely detection of acute appendicitis, prevention of unnecessary appendectomy, reduction in patient's length of stay in the hospital and decreasing health care costs.   Appendicitis diagnosis support vector machine artificial intelligence machine learning. 2017 8 01 339 348 http://ismj.bpums.ac.ir/article-1-886-en.pdf
56-887 2024-03-29 10.1002
Iranian South Medical Journal Iran South Med J 1735-4374 1735-6954 10.52547/ismj 2017 20 4 Extraction of Chondroitin Sulfate From Cartilage Sturgeon, Stellate Sturgeon (Acipenser stellatus) and its Inductive Effect on Human Fibroblast Proliferation Saead Delshad Katayon karimzadeh karimzadehkathy@yahoo.co.uk Ali Mostafaie Background: Chondroitin sulfates (CS) is one of the essential glycosaminoglycan’s which is found in sturgeon fishes and exists in the cartilage part of these fishes. In addition to food and cosmetic industries, these compounds have significant medical and clinical applications, mainly in the treatment of arthritis and wound healing. Materials and Methods: In this study, the chondroitin sulfate extraction was performed using pepsin and trypsin enzyme digestions in 12 and 18 hours intervals followed by cationic salt, cetyl pyridinium chloride (CPC) treatment. To investigate the effect of Chondroitin sulfate on induction of proliferation of fibroblasts isolated from human skin, MTT assay method was used, which was applied at different incubation times (24, 48 and 72 h). To determine the proper time and enzymatic digestion, after temperature treatment of samples using pepsin and trypsin enzymes, the SDS-PAGE electrophoresis was used. Moreover, the FT-IR analysis was performed to characterize the type of CS. Results: The maximum yield of enzymatic digestion was observed for trypsin digestion at 18h, according to electrophoresis patterns. The amount of CS yield was estimated at 4.76% in this situation. FT-IR analysis revealed that the CS belongs to the C4S type. Chondroitin sulfates extracting from cartilage showed the concentration-dependent effect on fibroblast cell proliferation. This dose-response effect showed 167% increase in proliferation at 10 µg/ml dose of CS compared to the control in fibroblast cells. Conclusion: Extracted CS has a positive stimulatory effect on fibroblast cells proliferation in a dose-dependent manner. So it can be used for fibroblast prolioferation induction for wound healing and repairing damaged tissues.     Cell proliferation Cartilage Chondroitin sulfate Acipenser stellatus 2017 8 01 349 361 http://ismj.bpums.ac.ir/article-1-887-en.pdf
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Iranian South Medical Journal Iran South Med J 1735-4374 1735-6954 10.52547/ismj 2017 20 4 Survey of Rodents Fauna Regarding to their Probabilistic Contamination to Leishmania (2013-2014) Mohammad Darvishi Reza Jafari Jafari_r@farabi.tums.ac.ir Hossean Darabi Iraj Zendehbodi Sayeas Abdolmanaf Jahangard Background: Tangistan County now is considered as one of the foci of zoonotic cutaneous leishmaniasis in Bushehr province. Rodents are the primary parasites reservoir of this disease (Leishmania major), and so far four of them have been identified as the main sources of the disease in the country. This research aimed to identify these rodents species and to determine the extent of contamination by Leishmania in Tangistan County. Materials and Methods: This research was a descriptive cross-sectional study, and the sample rodents were collected by using live traps. The captured rodents were identified based on their morphological characteristics by using valid detection keys.The captured rodents were anesthetized with chloroform, and then two smears were prepared from each subject by sanding method from each ear. Smears were dried and fixed with methanol. Finally, the smears were stained using standard Giemsa method and observed under the light microscope. Results: From the total of 187 collected samples from rodents, nine species were identified. Tatera indica with 70.6% was the dominant species. In this study, there were no rodents contaminated with Leishmania. All captured rodents were contaminated with lice and fleas. The primarily reported ectoparasites were fleas, mainly from xenopsylla cheopis and xenopsylla astia species. Conclusion: This study shows a high frequency of Tatera indica in this Tangistan county; also the previous studies have reported this species as the primary source of cutaneous leishmaniasis in the same region (southwestern Iran). Hence, Tatera indica could be considered as the main source for zoonotic cutaneous leishmaniasis (ZCL) in the future.   Fauna Rodents Leishmania Tangestan 2017 8 01 362 369 http://ismj.bpums.ac.ir/article-1-888-en.pdf
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Iranian South Medical Journal Iran South Med J 1735-4374 1735-6954 10.52547/ismj 2017 20 4 Evaluation of Lethal Effect of Pergularia Tomentosa and Priploca aphylla on Trichomonas Vaginalis In Vitro Morad Ali Fouladvand Solyman khorami Khorami_bu@yahoo.com Kohzad Sartavi Background: Trichomonas vaginalis protozoan is one of the causes of human vaginitis. The selective medicine for treatment is metronidazole. However, it has some adverse outcomes including increasing drug resistance and having numerous side effects. Pergularia tomentosa is a desert plant with some antifungal and anti-Plasmodium properties. Interestingly, the anti-dermatophytic effect of Priploca aphylla is more powerful than conventional antifungal drugs such as griseofulvin. In this study, we aimed to use its ingredients to introduce a new medicine for the treatment of Trichomonas vaginalis infections. Materials and Methods: Pergularia tomentosa and Periploca aphylla were collected, cleaned and dried. Then, plants main ingredients were extracted by using water, methanol, dichloromethane and n-hexane solvents. Then, herbal extracts with concentrations of 50, 100, 200, 400, 600, 800 µg/ml were prepared by adding normal saline and glycerin. Trichomonas vaginalis trophozoite with the concentration of 106/100 µl was mixed with 100 ml of an herbal extract of Pergularia tomentosa and Priploca aphylla. The mixture incubated for 24 hours at 37°C. The mortality rate of the protozoa was measured by using the MTT test, and the effect of extracts was evaluated on Vero cells. The phytochemical evaluation was performed using the HPTLC technique to determine the composition of the extract. All tests were repeated three times and SPSS software, version 16 was used for data analysis. Results: Anti-Trichomonas aqueous, methanol, dichloromethane and n-hexane extracts of Pergularia tomentosa in 800µg/ml concentration was % 64, % 72.4, %95.2 and % 95.4 respectively. Lethal effect on Trichomonas for Priploca aphylla with the same concentration was 70.8%, 67%, 93.4% and 93.2% respectively. Cytotoxic effect of methanol extracts of Pergularia tomentosa and Priploca aphylla at 800µg/ml concentration against Vero cells was %50.3 and %63 respectively. Phytochemical screening of herbal extracts showed that both have the same ingredients including alkaloid, flavonoid, terpenoid, saponin, sterol, phenol, iridoid, tannin, phenylpropanoid, and anthocyanins. Conclusion: The results showed that for Pergularia tomentosa and Priploca aphylla, the dichloromethane and n-hexane extracts were more effective against Trichomonas vaginalis than methanolic and water extracts in all concentrations. For the future research, identification of the mechanism of anti-Trichomonas vaginalis effect of these herbal ingredients is necessary.   Trichomonas vaginalis Pergularia tomentosa Priploca aphylla MTT Vero 2017 8 01 370 379 http://ismj.bpums.ac.ir/article-1-889-en.pdf
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Iranian South Medical Journal Iran South Med J 1735-4374 1735-6954 10.52547/ismj 2017 20 4 Ethnopharmacology of Medicinal Plants in the Southwest of Mond Mountain inabipour@gmail.com Background: Ethnopharmacology has been seen as a multidisciplinary approach for novel drug discovery by providing valuable data about medicinal plants in different cultures. The aim of this ethnopharmacological study was to identify medicinal plants in the Southwest of Mond Mountain in the North of Persian Gulf. Materials and Methods: The medical uses of medicinal plants were gathered from 20 local informants by face to face interviews. The relative frequency of citation (FRC) and cultural importance (CI) indices were calculated. Results: A total of 116 medicinal plants belonging to 65 families were identified. Zataria multiflora, Achillea eriophora DC, Foeniculum vulgare, Teucrium polium, Haplophyllum tuberculatum, Cuminum cyminum, Plantago psyllium, Nigella sativa and Aleo vera had the highest cultural importance indices. Zataria multiflora, Foeniculum vulgare, Nigella sativa, Cuminum cyminum, and Achillea eriophora DC  had the highest FRC indices. The highest medical uses were for gastrointestinal diseases, gynecological diseases, metabolic disorders, respiratory disorders and infectious diseases, respectively. Conclusion: There is a vast variety of medicinal plants in the Southwest of Mond Mountain. Although most of therapeutic applications of these plants in this region are the same as Iran’s traditional medicine, but the people in the Southwest of Mond Mountain use some of these plants for some diseases which are unique for this region. For example, the native people of this region used Zataria multiflora, Achillea eriophora DC, Foeniculum vulgare and Haplophyllum tuberculatum for abdominal pain, Nigella sativa for postpartum complications, Aleo vera for hyperlipidemia, Plantago psyllium for drainage of abscesses, Haplophyllum tuberculatum for infectious diseases and  muscular pain and Foeniculum vulgare for jaundice. Thus, investigation about these plants should be initiated to discover novel drugs for clinical applications.     Ethnopharmacology traditional medicine medicinal plants Bushehr 2017 8 01 380 398 http://ismj.bpums.ac.ir/article-1-890-en.pdf
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Iranian South Medical Journal Iran South Med J 1735-4374 1735-6954 10.52547/ismj 2017 20 4 The Prevalence of Hyperlipidemia Among Older People, Bushehr Elderly Health (BEH) Program Afshin Ostovar Zahra Fereidooni Amin Ansari MohammadJavad Haerinejad Hossean Darabi AliReza Raeisi GholamReza Heidari Bagher Larijani Neda Mehrdad Gita Shafiee Farshad Sharifi Zhaleh Shadman Mohammad Reza Amini Iraj Nabipour Inabipour@gmail.com Background: Life expectancy continues to increase and Iran’s older population grows dramatically. Old age is the strongest risk factor for developing atherosclerotic cardiovascular disease. Hence, effective lipid management can reduce the risk of developing cardiovascular disease. Materials and Methods: Between March 2013 and October 2014, a total of 3000 men and women aged ≥ 60 years, residing in Bushehr, Iran who participated in Bushehr Elderly Health (BEH) program were evaluated for dyslipidemia. Serum lipid levels in fasting state were measured using Selectra 2 auto analyzer. The cut-offs of cardiovascular risks were derived from the National Cholesterol Education Program (NCEP) guidelines in the United States (Adult Treatment Panel [ATP] III). Results: The prevalence rates for hypercholesterolemia (≥ 200 mg/dl), high LDL-cholesterol (≥ 130 mg/dl), low HDL-cholesterol (<40 mg/dl) and hypertriglyceridemia (≥ 150 mg/dl) were 48.0%, 42.4%, 29.6%, 35.5%, respectively. The prevalence of dyslipidemia was 87.8% in women and 80.2% in men. The prevalence rate of dyslipidemia was decreased in men with increasing age (p=0.003), however no change was observed in women. A total of 835 subjects (27.8%) used hypolipidemic drugs. The statins were the most common used hypolipidemic drugs. There were significant association between dyslipidemia and traditional cardiovascular risk factors such as diabetes mellitus, hypertension, and obesity (p<0.0001). Conclusion: Dyslipidemia is a prevalent abnormality among Bushehr‘s older population. Therefore, interventional measures for lipid management are suggested for this population.   Aging dyslipidemia cholesterol triglyceride elderly population 2017 8 01 399 415 http://ismj.bpums.ac.ir/article-1-892-en.pdf