دوره 27، شماره 4 - ( دوماهنامه طب جنوب 1403 )                   جلد 27 شماره 4 صفحات 318-297 | برگشت به فهرست نسخه ها


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Jamei E, Gallehgiryan M R, Shiravani M, Sadeghi A, Mahdi M, Nekooei M. The Antioxidant and Antitumor Effects of Al-gae from the Persian Gulf: A Systematic Re-view. Iran South Med J 2025; 27 (4) :297-318
URL: http://ismj.bpums.ac.ir/article-1-2094-fa.html
جامعی عرفان، گله‌گیریان محمدرضا، شیروانی معصومه، صادقی علی، مهدی محدثه، نکوئی مریم. اثرات آنتی‌اکسیدانی و ضد‌توموری جلبک‌های خلیج‌فارس: یک مرور نظام‌مند. مجله طب جنوب. 1403; 27 (4) :297-318

URL: http://ismj.bpums.ac.ir/article-1-2094-fa.html


1- کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی بوشهر، بوشهر، ایران
2- گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی بوشهر، بوشهر، ایران ، nekooei.maryam@yahoo.com
چکیده:   (99 مشاهده)
زمینه: در سال‌های اخیر، جلبک‌های دریایی به دلیل ترکیبات زیست ‌فعال خود، مورد توجه محققان قرار گرفته‌اند. با توجه به ذخایر گسترده جلبک‌های خلیج‌فارس، این مطالعه به بررسی خواص آنتی‌اکسیدانی و ضدتوموری این جلبک‌ها پرداخته است.
مواد و روش‌ها: مطالعات منتشر شده در مجموعه‌ای از پایگاه‌های معتبر علمی (PubMed، Web of Science، Scopus و Google scholar) به وسیله ترکیبی از عبارات MeSH و Emtree از ابتدا تا سال 2024 جستجو شدند. مطالعات مرتبط با اثرات آنتی‌اکسیدانی و ضدتوموری جلبک‌های خلیج‌فارس انتخاب و داده‌های مربوط به نام علمی جلبک، ترکیبات مؤثر حلال‌های استخراج، روش‌های سنجش و ترکیبات مؤثر استخراج شده و به‌صورت کیفی تحلیل شدند.
یافته‌ها: تعداد ۹۶ مطالعه در این مرور گنجانده شد. بیشترین تعداد مطالعات به جلبک‌های قهوه‌ای اختصاص داشت. در بین آن‌ها، برخی از گونه‌ها بیشترین فعالیت آنتی‌اکسیدانی را نشان دادند. همچنین، برخی از عصاره‌های جلبکی، به‌ویژه عصاره‌های استخراج ‌شده با حلال‌های آلی، قوی‌ترین اثرات ضدتوموری را داشتند. متانول و اتانول رایج‌ترین حلال‌های مورد استفاده برای استخراج ترکیبات آنتی‌اکسیدانی از جلبک‌های خلیج‌فارس بودند. علاوه بر این، سایر حلال‌های آلی مانند ان- هگزان، اتیل استات و دی‌کلرومتان، به‌طور کلی در فعالیت ضدتوموری عملکرد بهتری نسبت به حلال‌های آبی داشتند.
نتیجه‌گیری: جلبک‌های خلیج‌فارس به‌عنوان منبع غنی از ترکیبات زیست‌فعال، پتانسیل بالایی درمان سرطان و کاهش استرس اکسیداتیو دارند. با این‌حال، تحقیقات بیشتری برای بهره‌برداری بهینه از این منابع ضروری در پزشکی و توسعه دارو مورد نیاز است.
 
متن کامل [PDF 949 kb]   (73 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: بیوتکنولوژی دریا
دریافت: 1403/10/18 | پذیرش: 1403/11/30 | انتشار: 1403/12/20

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